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- W4285264134 abstract "Degradomics studies the protease-substrate repertoire. The breakdown products generated are key components of the secondary molecular changes following the spinal cord injury. Analytical and structural methodologies in proteomic technology have deciphered the complex molecular pattern of spinal cord injury, involving the proteolysis of cytoskeletal proteins, extracellular matrix, ion channels, and cell junction proteins. These proteins, when degraded, constitute the pillars of cellular injury and neuronal apoptosis. The physiological balance of protein and proteases is disrupted when there is uncontrolled activation of the proteolytic process. The neuronal structural and functional integrity is then dysregulated, hindering the regenerative process, and remyelination. Calpains, caspases, cathepsins, and matrix metalloproteinases are the main proteases involved in the disability following the secondary neuronal injury. This chapter reviews the latest discoveries regarding degradomics in spinal cord injury and sheds the light on the newest targeted therapies that can be future potential to ameliorate neuroplasticity, decrease secondary injury, and improve neurological and functional outcomes." @default.
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- W4285264134 date "2022-01-01" @default.
- W4285264134 modified "2023-09-25" @default.
- W4285264134 title "Protein degradome in spinal cord injury" @default.
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- W4285264134 doi "https://doi.org/10.1016/b978-0-12-822427-4.00011-3" @default.
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