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• W4285280244 abstract "Free radicals are very reactive because of the availability of unpaired electrons in their outer shell. They are generated inside the cell either as by-products of metabolism or due to the mitochondrial dysfunction. Reactive oxygen species (ROS) are nonreactive; however, they have the potential to produce free radicals. They are also the by-product of metabolism generated mainly from the electron leakage during the process of cellular respiration. Oxidative stress (OS), is a disorder situation, where the generation of ROS inside the system surpasses the antioxidant defense system of the body. This disparity may be a result of altered antioxidant capacity because of compromised production, distribution of antioxidant molecule, or the overproduction of ROS from endogenous sources or external stresses. Excess ROS has a detrimental effect on cellular macromolecules such as lipid, proteins, or DNA, which results in improper signal transduction pathways. Therefore the OS has been occupied a place in the growing list of human diseases such as cancer, hepatotoxicity, neurodegeneration, cardiovascular as well as in aging symptoms." @default.
• W4285280244 created "2022-07-14" @default.
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• W4285280244 date "2022-01-01" @default.
• W4285280244 modified "2023-09-25" @default.
• W4285280244 title "The oxidative stress: Causes, free radicals, targets, mechanisms, affected organs, effects, indicators" @default.
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• W4285280244 doi "https://doi.org/10.1016/b978-0-12-819096-8.00012-4" @default.
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