Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285280995> ?p ?o ?g. }
- W4285280995 endingPage "1006" @default.
- W4285280995 startingPage "991" @default.
- W4285280995 abstract "Abstract Small nuclear RNAs (snRNAs) are rarely reported in cancer. This study is based on The Cancer Genome Atlas genome-wide data set to explore the prognostic value and molecular mechanism of snRNAs in gastric cancer (GC). Gene ontology, Kyoto Encyclopedia of Genes and Genomes, and gene set enrichment analysis were used to explore the molecular mechanism of snRNAs. A total of 351 patients were included in the survival analysis, and 14 prognostic snRNAs were identified using multivariate survival analysis. We constructed a prognostic signature containing nine snRNAs, which can signally classify patients into high- and low-risk phenotypes (adjusted P < 0.0001, hazard ratio = 2.671, 95% confidence interval = 1.850–3.858). Combining the molecular mechanisms obtained by the three functional enrichment approaches, we concluded that this prognostic signature snRNAs participated in classical tumor-related signaling pathways, including Notch, PI3K, toll-like receptor, etc.; cell adhesion; cell cycle; cell proliferation; and other biological processes that affect the biological phenotype of cancer cells. We also found significant downregulation of the abundance of immune cell infiltrates and immune microenvironment scores for high-risk phenotypes of GC patients. In conclusion, this study has identified 14 prognostic snRNAs signally associated with GC overall survival and also constructed a novel prognostic signature containing nine prognostic snRNAs." @default.
- W4285280995 created "2022-07-14" @default.
- W4285280995 creator A5017930739 @default.
- W4285280995 creator A5039391697 @default.
- W4285280995 creator A5045570568 @default.
- W4285280995 creator A5048493212 @default.
- W4285280995 date "2022-01-01" @default.
- W4285280995 modified "2023-09-27" @default.
- W4285280995 title "Comprehensive analysis of molecular mechanism and a novel prognostic signature based on small nuclear RNA biomarkers in gastric cancer patients" @default.
- W4285280995 cites W1781118983 @default.
- W4285280995 cites W1966327575 @default.
- W4285280995 cites W1986989569 @default.
- W4285280995 cites W2035618305 @default.
- W4285280995 cites W2052935729 @default.
- W4285280995 cites W2085649502 @default.
- W4285280995 cites W2095725724 @default.
- W4285280995 cites W2101098226 @default.
- W4285280995 cites W2113974046 @default.
- W4285280995 cites W2114104545 @default.
- W4285280995 cites W2123879591 @default.
- W4285280995 cites W2126547130 @default.
- W4285280995 cites W2130430382 @default.
- W4285280995 cites W2148393113 @default.
- W4285280995 cites W2153833484 @default.
- W4285280995 cites W2158217645 @default.
- W4285280995 cites W2158485828 @default.
- W4285280995 cites W2159707944 @default.
- W4285280995 cites W2161271012 @default.
- W4285280995 cites W2165605869 @default.
- W4285280995 cites W2272984102 @default.
- W4285280995 cites W2514258009 @default.
- W4285280995 cites W2604884404 @default.
- W4285280995 cites W2861975976 @default.
- W4285280995 cites W2944525119 @default.
- W4285280995 cites W2946473319 @default.
- W4285280995 cites W2951493619 @default.
- W4285280995 cites W2979923810 @default.
- W4285280995 cites W2980128108 @default.
- W4285280995 cites W2990042319 @default.
- W4285280995 cites W2992033677 @default.
- W4285280995 cites W2998840182 @default.
- W4285280995 cites W2998954971 @default.
- W4285280995 cites W3011709397 @default.
- W4285280995 cites W3048472400 @default.
- W4285280995 cites W3084052359 @default.
- W4285280995 cites W3149677189 @default.
- W4285280995 cites W3169716683 @default.
- W4285280995 cites W3175752499 @default.
- W4285280995 cites W3199722767 @default.
- W4285280995 cites W3201715468 @default.
- W4285280995 cites W3209090874 @default.
- W4285280995 cites W4210990885 @default.
- W4285280995 doi "https://doi.org/10.1515/med-2022-0493" @default.
- W4285280995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35733621" @default.
- W4285280995 hasPublicationYear "2022" @default.
- W4285280995 type Work @default.
- W4285280995 citedByCount "0" @default.
- W4285280995 crossrefType "journal-article" @default.
- W4285280995 hasAuthorship W4285280995A5017930739 @default.
- W4285280995 hasAuthorship W4285280995A5039391697 @default.
- W4285280995 hasAuthorship W4285280995A5045570568 @default.
- W4285280995 hasAuthorship W4285280995A5048493212 @default.
- W4285280995 hasBestOaLocation W42852809951 @default.
- W4285280995 hasConcept C104317684 @default.
- W4285280995 hasConcept C121608353 @default.
- W4285280995 hasConcept C126322002 @default.
- W4285280995 hasConcept C127716648 @default.
- W4285280995 hasConcept C143998085 @default.
- W4285280995 hasConcept C150194340 @default.
- W4285280995 hasConcept C152724338 @default.
- W4285280995 hasConcept C162317418 @default.
- W4285280995 hasConcept C207103383 @default.
- W4285280995 hasConcept C2779733811 @default.
- W4285280995 hasConcept C29537977 @default.
- W4285280995 hasConcept C44249647 @default.
- W4285280995 hasConcept C502942594 @default.
- W4285280995 hasConcept C54355233 @default.
- W4285280995 hasConcept C60644358 @default.
- W4285280995 hasConcept C70721500 @default.
- W4285280995 hasConcept C71924100 @default.
- W4285280995 hasConcept C86803240 @default.
- W4285280995 hasConceptScore W4285280995C104317684 @default.
- W4285280995 hasConceptScore W4285280995C121608353 @default.
- W4285280995 hasConceptScore W4285280995C126322002 @default.
- W4285280995 hasConceptScore W4285280995C127716648 @default.
- W4285280995 hasConceptScore W4285280995C143998085 @default.
- W4285280995 hasConceptScore W4285280995C150194340 @default.
- W4285280995 hasConceptScore W4285280995C152724338 @default.
- W4285280995 hasConceptScore W4285280995C162317418 @default.
- W4285280995 hasConceptScore W4285280995C207103383 @default.
- W4285280995 hasConceptScore W4285280995C2779733811 @default.
- W4285280995 hasConceptScore W4285280995C29537977 @default.
- W4285280995 hasConceptScore W4285280995C44249647 @default.
- W4285280995 hasConceptScore W4285280995C502942594 @default.
- W4285280995 hasConceptScore W4285280995C54355233 @default.
- W4285280995 hasConceptScore W4285280995C60644358 @default.
- W4285280995 hasConceptScore W4285280995C70721500 @default.
- W4285280995 hasConceptScore W4285280995C71924100 @default.