FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285285842> ?p ?o ?g. }

• W4285285842 endingPage "1002" @default.
• W4285285842 startingPage "991" @default.
• W4285285842 abstract "Gynostemma pentaphyllum (GP) is a plant commonly used in diabetic therapy in China. GP having potent antioxidant effect against various free radicals. The purpose of the current investigation to identify the cardioprotective effect of GP against streptozotocin (STZ)/ high fat diet (HFD) induced cardiac dysfunction in rats via alteration of AMPK/Nrf2/HO-1 pathway. Wistar rats were used for the current protocol. The rats were received the intraperitoneal injection of STZ and HFD to induce the cardiac remodelling. Blood glucose level, insulin and lipid parameters were estimated. Blood pressure and heart rate were also estimated. Cardiac parameters, antioxidant, cytokines, total protein and inflammatory mediators were analysed. The mRNA expression was detected using the RT-qPCR, respectively. GP significantly (p < 0.001) decreased the BGL and improved the insulin level. GP altered the ratio of heart/BW, liver/BW, and lung/BW. GP treatment significantly (p < 0.001) suppressed the heart rate and blood pressure (diastolic, systolic and mean pressure). GP significantly (p < 0.001) reduced the level of TC, LDL, TG, VLDL and increased the level of HDL. DCM induced rats received the GP administration exhibited reduction in the level of CK and LDH. GP significantly (p < 0.001) reduced the levels of MDA, hydrogen peroxide, peroxynitrite, ROS and increased the level of GSH, SOD, CAT and GPx. GP significantly (p < 0.001) reduced the levels of cytokines (TNF-α, IL-6, IL-1β) and inflammatory parameters (COX-2 and NFκB). GP significantly (p < 0.001) suppressed the NLRP3 and NF-κB expression. GP also boosted mitochondrial biogenesis by boosting the PGC-1α, HO-1 and Nrf2 expression in cardiac tissue. GP treatment showed the cardioprotective effects against STZ induced diabetic cardiac dysfunction via alteration of AMPK/Nrf2/HO-1 pathway." @default.
• W4285285842 created "2022-07-14" @default.
• W4285285842 creator A5029283570 @default.
• W4285285842 creator A5036012526 @default.
• W4285285842 creator A5043729225 @default.
• W4285285842 creator A5047452963 @default.
• W4285285842 creator A5083703240 @default.
• W4285285842 date "2022-01-01" @default.
• W4285285842 modified "2023-10-14" @default.
• W4285285842 title "Cardioprotective Effect of <i>Gynostemma pentaphyllum</i> against Streptozotocin Induced Cardiac Toxicity in Rats via Alteration of AMPK/Nrf2/HO-1 Pathway" @default.
• W4285285842 cites W1738287572 @default.
• W4285285842 cites W2017262960 @default.
• W4285285842 cites W2058706609 @default.
• W4285285842 cites W2073182272 @default.
• W4285285842 cites W2150702412 @default.
• W4285285842 cites W2270684689 @default.
• W4285285842 cites W2522325528 @default.
• W4285285842 cites W2593894711 @default.
• W4285285842 cites W2603126331 @default.
• W4285285842 cites W2614021004 @default.
• W4285285842 cites W2756104041 @default.
• W4285285842 cites W2772652485 @default.
• W4285285842 cites W2777429769 @default.
• W4285285842 cites W2789576267 @default.
• W4285285842 cites W2797273860 @default.
• W4285285842 cites W2896072322 @default.
• W4285285842 cites W2897134599 @default.
• W4285285842 cites W2900647187 @default.
• W4285285842 cites W2911875940 @default.
• W4285285842 cites W2914104637 @default.
• W4285285842 cites W2947619243 @default.
• W4285285842 cites W2954183412 @default.
• W4285285842 cites W2957516911 @default.
• W4285285842 cites W2980971679 @default.
• W4285285842 cites W2981944063 @default.
• W4285285842 cites W2995547731 @default.
• W4285285842 cites W3007289798 @default.
• W4285285842 cites W3007783655 @default.
• W4285285842 cites W3026637245 @default.
• W4285285842 cites W3038301976 @default.
• W4285285842 cites W3048319835 @default.
• W4285285842 cites W3083986414 @default.
• W4285285842 cites W3095630081 @default.
• W4285285842 cites W3104108415 @default.
• W4285285842 cites W3112237346 @default.
• W4285285842 cites W3118634522 @default.
• W4285285842 cites W3121781087 @default.
• W4285285842 cites W3123688328 @default.
• W4285285842 cites W3135121227 @default.
• W4285285842 cites W616481914 @default.
• W4285285842 doi "https://doi.org/10.5650/jos.ess21281" @default.
• W4285285842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35781259" @default.
• W4285285842 hasPublicationYear "2022" @default.
• W4285285842 type Work @default.
• W4285285842 citedByCount "2" @default.
• W4285285842 countsByYear W42852858422023 @default.
• W4285285842 crossrefType "journal-article" @default.
• W4285285842 hasAuthorship W4285285842A5029283570 @default.
• W4285285842 hasAuthorship W4285285842A5036012526 @default.
• W4285285842 hasAuthorship W4285285842A5043729225 @default.
• W4285285842 hasAuthorship W4285285842A5047452963 @default.
• W4285285842 hasAuthorship W4285285842A5083703240 @default.
• W4285285842 hasBestOaLocation W42852858421 @default.
• W4285285842 hasConcept C126322002 @default.
• W4285285842 hasConcept C134018914 @default.
• W4285285842 hasConcept C164027704 @default.
• W4285285842 hasConcept C184235292 @default.
• W4285285842 hasConcept C185592680 @default.
• W4285285842 hasConcept C2775838275 @default.
• W4285285842 hasConcept C2776151105 @default.
• W4285285842 hasConcept C2776914184 @default.
• W4285285842 hasConcept C2778004101 @default.
• W4285285842 hasConcept C2778270857 @default.
• W4285285842 hasConcept C2778713507 @default.
• W4285285842 hasConcept C2778760513 @default.
• W4285285842 hasConcept C2779280383 @default.
• W4285285842 hasConcept C2780124434 @default.
• W4285285842 hasConcept C2780159080 @default.
• W4285285842 hasConcept C43617362 @default.
• W4285285842 hasConcept C4725764 @default.
• W4285285842 hasConcept C55493867 @default.
• W4285285842 hasConcept C555293320 @default.
• W4285285842 hasConcept C71924100 @default.
• W4285285842 hasConcept C84393581 @default.
• W4285285842 hasConcept C97029542 @default.
• W4285285842 hasConcept C98274493 @default.
• W4285285842 hasConceptScore W4285285842C126322002 @default.
• W4285285842 hasConceptScore W4285285842C134018914 @default.
• W4285285842 hasConceptScore W4285285842C164027704 @default.
• W4285285842 hasConceptScore W4285285842C184235292 @default.
• W4285285842 hasConceptScore W4285285842C185592680 @default.
• W4285285842 hasConceptScore W4285285842C2775838275 @default.
• W4285285842 hasConceptScore W4285285842C2776151105 @default.
• W4285285842 hasConceptScore W4285285842C2776914184 @default.
• W4285285842 hasConceptScore W4285285842C2778004101 @default.
• W4285285842 hasConceptScore W4285285842C2778270857 @default.
• W4285285842 hasConceptScore W4285285842C2778713507 @default.
• W4285285842 hasConceptScore W4285285842C2778760513 @default.

• next