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• W4285289675 abstract "Immune cells exhibit continuous adaptative and dynamic metabolic adaptations and generate immune response to neoplastic cells. In view of metabolic adaptations coupled to the development of tumor immunity, immune cell metabolites are excellent models to study the functional outcomes of cellular metabolism. These metabolic adaptations guide differentiation of immune cells into distinct cellular states and activation of T cells and macrophages. Understanding these intricacies will help us understand how differential metabolic regulation of immune cell metabolites works through signaling pathways. The surrounding tumor microenvironment (TME) also influences the adjacent neoplastic cells, and cross talk between these facilitates tumor progression. Glucose metabolism is the key moiety which regulates metabolic adaptations and directs the activity of immune cell metabolites. It is well understood that the immune cell metabolites are the key molecules driving rapid adaptation in metabolic pathways. This is a dynamic yet closely coupled mechanism in cancer cells and the surrounding TME and the precise mechanism of how bidirectional interactions manifest in driving tumor progression still needs further evaluation. Metabolic reprograming also affects B cells, T cells, dendritic cells, macrophages, and myeloid-derived suppressor cells (MDSCs) among other immune cells. The role of these immune cells in TME is mainly dependable on the concentration and nature of numerous factors, like diffusible metabolites (i.e., lactate), reactive oxygen species (ROS), cytokines, and growth factors. In this chapter, we highlight the role of immune cell metabolites as fuel for driving oncogenic progression. We have summarized the key moieties of immune cells and representatives of lymphoid and myeloid lineages and linked them to understanding how they drive metabolic changes directing towards cancer progression. We also emphasize on the potential role of TME interactions in driving metabolic adaptations and how targeting metabolic reprogramming is being explored as a potential therapeutic strategy for anticancer treatment in conjunction with established chemotherapies and immunotherapies." @default.
• W4285289675 created "2022-07-14" @default.
• W4285289675 creator A5031466145 @default.
• W4285289675 creator A5032683385 @default.
• W4285289675 creator A5051485626 @default.
• W4285289675 creator A5076690824 @default.
• W4285289675 date "2022-01-01" @default.
• W4285289675 modified "2023-09-28" @default.
• W4285289675 title "Immune Cell Metabolites as Fuel for Cancer Cells" @default.
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