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- W4285290844 endingPage "141" @default.
- W4285290844 startingPage "107" @default.
- W4285290844 abstract "Cytokines are pleiotropic soluble proteins used by immune cells to orchestrate a coordinated response against pathogens and malignancies. In cancer immunotherapy, cytokine-based drugs can be developed potentiating pro-inflammatory cytokines or blocking immunosuppressive cytokines. However, the complexity of the mechanisms of action of cytokines requires the use of biotechnological strategies to minimize systemic toxicity, while potentiating the antitumor response. Sequence mutagenesis, fusion proteins and gene therapy strategies are employed to enhance the half-life in circulation, target the desired bioactivity to the tumor microenvironment, and to optimize the therapeutic window of cytokines. In this review, we provide an overview of the different strategies currently being pursued in pre-clinical and clinical studies to make the most of cytokines for cancer immunotherapy." @default.
- W4285290844 created "2022-07-14" @default.
- W4285290844 creator A5002953299 @default.
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- W4285290844 creator A5088139094 @default.
- W4285290844 creator A5088458904 @default.
- W4285290844 creator A5088679346 @default.
- W4285290844 date "2022-01-01" @default.
- W4285290844 modified "2023-10-17" @default.
- W4285290844 title "Overcoming the limitations of cytokines to improve cancer therapy" @default.
- W4285290844 cites W1570245632 @default.
- W4285290844 cites W1576522185 @default.
- W4285290844 cites W1636327287 @default.
- W4285290844 cites W1828940258 @default.
- W4285290844 cites W1879004178 @default.
- W4285290844 cites W188630774 @default.
- W4285290844 cites W1936300843 @default.
- W4285290844 cites W1950572133 @default.
- W4285290844 cites W1963706689 @default.
- W4285290844 cites W1967971602 @default.
- W4285290844 cites W1969427823 @default.
- W4285290844 cites W1970308473 @default.
- W4285290844 cites W1976415203 @default.
- W4285290844 cites W1978283443 @default.
- W4285290844 cites W1980220254 @default.
- W4285290844 cites W1983412131 @default.
- W4285290844 cites W1984621921 @default.
- W4285290844 cites W1991804259 @default.
- W4285290844 cites W2002516695 @default.
- W4285290844 cites W2004538946 @default.
- W4285290844 cites W2009644403 @default.
- W4285290844 cites W2009900556 @default.
- W4285290844 cites W2010931467 @default.
- W4285290844 cites W2017344199 @default.
- W4285290844 cites W2017382139 @default.
- W4285290844 cites W2017691530 @default.
- W4285290844 cites W2024043434 @default.
- W4285290844 cites W2025980739 @default.
- W4285290844 cites W2027014013 @default.
- W4285290844 cites W2028232456 @default.
- W4285290844 cites W2032368145 @default.
- W4285290844 cites W2038428454 @default.
- W4285290844 cites W2039422212 @default.
- W4285290844 cites W2046562334 @default.
- W4285290844 cites W2047102094 @default.
- W4285290844 cites W2048504768 @default.
- W4285290844 cites W2053330214 @default.
- W4285290844 cites W2053538857 @default.
- W4285290844 cites W2054363200 @default.
- W4285290844 cites W2060336321 @default.
- W4285290844 cites W2061945948 @default.
- W4285290844 cites W2063218301 @default.
- W4285290844 cites W2064856766 @default.
- W4285290844 cites W2067012451 @default.
- W4285290844 cites W2068173904 @default.
- W4285290844 cites W2078923880 @default.
- W4285290844 cites W2081231410 @default.
- W4285290844 cites W2082557374 @default.
- W4285290844 cites W2084659308 @default.
- W4285290844 cites W2086244192 @default.
- W4285290844 cites W2090247488 @default.
- W4285290844 cites W2093312029 @default.
- W4285290844 cites W2098930115 @default.
- W4285290844 cites W2101792649 @default.
- W4285290844 cites W2109274792 @default.
- W4285290844 cites W2110151585 @default.
- W4285290844 cites W2112744121 @default.
- W4285290844 cites W2114160093 @default.
- W4285290844 cites W2116089582 @default.
- W4285290844 cites W2119312822 @default.
- W4285290844 cites W2122057254 @default.
- W4285290844 cites W2122387392 @default.
- W4285290844 cites W2123914905 @default.
- W4285290844 cites W2125270092 @default.
- W4285290844 cites W2127401827 @default.
- W4285290844 cites W2128319428 @default.
- W4285290844 cites W2132173287 @default.
- W4285290844 cites W2133439754 @default.
- W4285290844 cites W2133572151 @default.
- W4285290844 cites W2139468467 @default.
- W4285290844 cites W2149874032 @default.
- W4285290844 cites W2151756487 @default.
- W4285290844 cites W2155664228 @default.
- W4285290844 cites W2160075959 @default.
- W4285290844 cites W2199775161 @default.
- W4285290844 cites W2269860277 @default.
- W4285290844 cites W2313751154 @default.
- W4285290844 cites W2329318318 @default.
- W4285290844 cites W2334694951 @default.
- W4285290844 cites W2345624579 @default.
- W4285290844 cites W2514572740 @default.
- W4285290844 cites W2556133499 @default.
- W4285290844 cites W2587775812 @default.
- W4285290844 cites W2602505844 @default.
- W4285290844 cites W2605067960 @default.