Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285294503> ?p ?o ?g. }
- W4285294503 abstract "Lewy body diseases are pathologically characterized by α-synuclein pathology. Alzheimer's disease (AD) co-pathology can influence phenotypes. In vivo AD biomarkers can suggest the presence of this co-pathology in unusual cases, but pathological validation remains essential.This patient originally presented with corticobasal syndrome and later developed visual hallucinations and parkinsonism consistent with a synucleinopathy. The patient underwent CSF sampling, 18F-flortaucipir PET scanning, and brain donation with bilateral regions available for digital histological analysis.CSF Aβ42 and t-tau were in the AD range. 18F-flortaucipir scanning showed right-lateralized retention in all lobes (t = 4.3-10.0, P < .006). Neocortical stage Lewy body pathology and high levels of AD neuropathological changes were present at autopsy. There was right lateralization of α-synuclein and tau pathology (T value = 3.1, P value = .007 and T value = 3.3, P value = .004 respectively).This case with overlapping tauopathy and synucleinopathy clinical features had in-depth biomarker characterization and rare bilateral post-mortem sampling showing lateralized tau and α-synuclein pathology suggesting possible synergistic relationships." @default.
- W4285294503 created "2022-07-14" @default.
- W4285294503 creator A5015541853 @default.
- W4285294503 creator A5021394368 @default.
- W4285294503 creator A5021597228 @default.
- W4285294503 creator A5035213245 @default.
- W4285294503 creator A5037938359 @default.
- W4285294503 creator A5049854864 @default.
- W4285294503 creator A5051112477 @default.
- W4285294503 creator A5061968243 @default.
- W4285294503 creator A5081337965 @default.
- W4285294503 date "2022-01-01" @default.
- W4285294503 modified "2023-10-16" @default.
- W4285294503 title "Lateralized <i>ante mortem</i> and <i>post mortem</i> pathology in a case of Lewy body disease with corticobasal syndrome" @default.
- W4285294503 cites W1965937904 @default.
- W4285294503 cites W1968108346 @default.
- W4285294503 cites W2041390299 @default.
- W4285294503 cites W2061287016 @default.
- W4285294503 cites W2064284597 @default.
- W4285294503 cites W2128228199 @default.
- W4285294503 cites W2144707045 @default.
- W4285294503 cites W2506427984 @default.
- W4285294503 cites W2559809511 @default.
- W4285294503 cites W2566744941 @default.
- W4285294503 cites W2623521763 @default.
- W4285294503 cites W2788017075 @default.
- W4285294503 cites W2807715468 @default.
- W4285294503 cites W2905123367 @default.
- W4285294503 cites W2922166984 @default.
- W4285294503 cites W2952481429 @default.
- W4285294503 cites W2982476101 @default.
- W4285294503 cites W3081032721 @default.
- W4285294503 cites W3093572537 @default.
- W4285294503 cites W3096349182 @default.
- W4285294503 cites W4285294503 @default.
- W4285294503 doi "https://doi.org/10.1002/trc2.12294" @default.
- W4285294503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35592691" @default.
- W4285294503 hasPublicationYear "2022" @default.
- W4285294503 type Work @default.
- W4285294503 citedByCount "1" @default.
- W4285294503 countsByYear W42852945032022 @default.
- W4285294503 crossrefType "journal-article" @default.
- W4285294503 hasAuthorship W4285294503A5015541853 @default.
- W4285294503 hasAuthorship W4285294503A5021394368 @default.
- W4285294503 hasAuthorship W4285294503A5021597228 @default.
- W4285294503 hasAuthorship W4285294503A5035213245 @default.
- W4285294503 hasAuthorship W4285294503A5037938359 @default.
- W4285294503 hasAuthorship W4285294503A5049854864 @default.
- W4285294503 hasAuthorship W4285294503A5051112477 @default.
- W4285294503 hasAuthorship W4285294503A5061968243 @default.
- W4285294503 hasAuthorship W4285294503A5081337965 @default.
- W4285294503 hasBestOaLocation W42852945031 @default.
- W4285294503 hasConcept C142724271 @default.
- W4285294503 hasConcept C15744967 @default.
- W4285294503 hasConcept C207886595 @default.
- W4285294503 hasConcept C2776477761 @default.
- W4285294503 hasConcept C2776525014 @default.
- W4285294503 hasConcept C2776925932 @default.
- W4285294503 hasConcept C2776936178 @default.
- W4285294503 hasConcept C2777739294 @default.
- W4285294503 hasConcept C2779097696 @default.
- W4285294503 hasConcept C2779134260 @default.
- W4285294503 hasConcept C2779504383 @default.
- W4285294503 hasConcept C2779734285 @default.
- W4285294503 hasConcept C2780130745 @default.
- W4285294503 hasConcept C2781449126 @default.
- W4285294503 hasConcept C71924100 @default.
- W4285294503 hasConceptScore W4285294503C142724271 @default.
- W4285294503 hasConceptScore W4285294503C15744967 @default.
- W4285294503 hasConceptScore W4285294503C207886595 @default.
- W4285294503 hasConceptScore W4285294503C2776477761 @default.
- W4285294503 hasConceptScore W4285294503C2776525014 @default.
- W4285294503 hasConceptScore W4285294503C2776925932 @default.
- W4285294503 hasConceptScore W4285294503C2776936178 @default.
- W4285294503 hasConceptScore W4285294503C2777739294 @default.
- W4285294503 hasConceptScore W4285294503C2779097696 @default.
- W4285294503 hasConceptScore W4285294503C2779134260 @default.
- W4285294503 hasConceptScore W4285294503C2779504383 @default.
- W4285294503 hasConceptScore W4285294503C2779734285 @default.
- W4285294503 hasConceptScore W4285294503C2780130745 @default.
- W4285294503 hasConceptScore W4285294503C2781449126 @default.
- W4285294503 hasConceptScore W4285294503C71924100 @default.
- W4285294503 hasFunder F4320308392 @default.
- W4285294503 hasFunder F4320332161 @default.
- W4285294503 hasIssue "1" @default.
- W4285294503 hasLocation W42852945031 @default.
- W4285294503 hasLocation W42852945032 @default.
- W4285294503 hasLocation W42852945033 @default.
- W4285294503 hasOpenAccess W4285294503 @default.
- W4285294503 hasPrimaryLocation W42852945031 @default.
- W4285294503 hasRelatedWork W1902303720 @default.
- W4285294503 hasRelatedWork W2000797334 @default.
- W4285294503 hasRelatedWork W2100359559 @default.
- W4285294503 hasRelatedWork W213324314 @default.
- W4285294503 hasRelatedWork W2134891039 @default.
- W4285294503 hasRelatedWork W2160379613 @default.
- W4285294503 hasRelatedWork W2286226908 @default.
- W4285294503 hasRelatedWork W243251906 @default.
- W4285294503 hasRelatedWork W2610279067 @default.
- W4285294503 hasRelatedWork W3150971613 @default.