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- W4285296034 abstract "Intronless genes (IGs) or single-exon genes lacking introns are found across Eukaryotes. IGs are not regulated by the splicing machinery and may be subject to lower post-transcriptional gene expression variability. Therefore, IGs might be potential candidates for biomarkers with better predictability and easier regulation as targets for therapy. Cancer is a complex disease that relies on progressive uncontrolled cell division linked with multiple dysfunctional biological processes. Tumor heterogeneity remains the most challenging feature in cancer diagnosis and treatment. Given the clinical relevance of IGs, we aim to identify their unique expression profiles and interactome, that may act as functional signatures across eight different cancers. We identified 940 protein-coding IGs in the human genome, of which about 35% were differentially expressed across the analyzed cancer datasets. Specifically, 78% of differentially expressed IGs were undergoing transcriptional reprogramming with elevated expression in tumor cells. Remarkably, in all the studied tumors, a highly conserved induction of a group of deacetylase-histones located in a region of chromosome 6 enriched in nucleosome and chromatin condensation processes. This study highlights that differentially expressed human intronless genes across cancer types are prevalent in epigenetic regulatory roles participating in specific protein-protein interaction (PPI) networks for ESCA, GBM, and LUAD tumors. We determine that IGs play a key role in the tumor phenotype at transcriptional and post-transcriptional levels, with important mechanisms such as interactomics rewiring." @default.
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- W4285296034 date "2022-01-01" @default.
- W4285296034 modified "2023-09-27" @default.
- W4285296034 title "Deciphering the Tissue-Specific Regulatory Role of Intronless Genes Across Cancers" @default.
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- W4285296034 doi "https://doi.org/10.1007/978-3-031-06220-9_18" @default.
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