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• W4285296301 startingPage "50" @default.
• W4285296301 abstract "We characterized the absorption, distribution, metabolism, and excretion of tetrabromobisphenol A (TeBBPA) in C57BL/6 mice. After TeBBPA dosing, we monitored the mice and collected samples for 24 h. Most TeBBPA was excreted in the feces at 12 h. At 24 h, 71% of administered TeBBPA was found in the feces and TeBBPA-conjugates were detected at 17.8%. We also detected debrominated metabolites of TeBBPA, including tribromobisphenol A (TriBBPA), dibromobisphenol A (DiBBPA), and monobromobisphenol A (MoBBPA). TeBBPA, TriBBPA, 2,2′-DiBBPA and MoBBPA were detected in dam’s blood between 30 min and 1 h. Moreover, TriBBPA and 2,2′-DiBBPA were detected in milk at 30 min. The primary metabolites of TeBBPA were formed by conjugation, whereas debromination represented a minor metabolism pathway. Moreover, our findings demonstrated that the parent TeBBPA compound and its debrominated metabolites were distributed into the maternal milk of mice and transferred to the nursing pups following TeBBPA oral administration." @default.
• W4285296301 created "2022-07-14" @default.
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• W4285296301 date "2022-01-01" @default.
• W4285296301 modified "2023-09-26" @default.
• W4285296301 title "Distribution, Metabolism, Excretion, and Lactational Transfer to Pups of Tetrabromobisphenol A and Its Metabolites in C57BL/6 Mice" @default.
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• W4285296301 doi "https://doi.org/10.1248/bpbreports.5.3_50" @default.
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