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• W4285299212 abstract "Appending of ferrocene (Fc) to biologically-active organic backbones can generate novel multi-functional species for targeting bacteria and cancer. In this work Fc was linked to coumarin and anthraquinone with the goal of harnessing the redox-active Fc centre to generate new compounds that exhibit cytoxicity through the generation of toxic reactive oxygen species (ROS). A Cu(I)-catalyzed azide-alkyne cycloaddition click reaction was used to connect the organic and Fc components via a triazole linker. Cyclic voltammetry shows that the Fc potentials are suitable for oxidation by biological hydrogen peroxide to give reactive ferrocenium (Fc+) species, which can then generate hydroxyl radicals. The ability of the compounds to generate hydroxyl radicals in the presence of hydrogen peroxide was shown directly using EPR spin-trapping experiments. Furthermore, in vitro studies in MCF-7 breast cancer cells show significant increases in ROS following incubation with the Fc-functionalized compounds. Screening for antibacterial activity produced negative results for all of the Fc compounds, consitent with low levels of hydrogen peroxide typically found in bacteria. By contrast, Fc-coumarin showed cytotoxicity against A549 lung cancer and SKOV3 ovarian cancer cell lines, whereas the parent compound was inactive. This is consistent both with the cytoxic potential of the Fc group and the elevated hydrogen peroxide levels found in many cancers. Interestingly, the anthraquinone compounds showed the opposite effect with the parent compounds showing modest activity against A549 cells, but the Fc compounds being inactive. This demonstrates other potential negative impacts of including Fc, such as significantly increased lipophilicity." @default.
• W4285299212 created "2022-07-14" @default.
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• W4285299212 date "2022-01-01" @default.
• W4285299212 modified "2023-10-16" @default.
• W4285299212 title "Ferrocene-appended anthraquinone and coumarin as redox-active cytotoxins" @default.
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• W4285299212 cites W1833111122 @default.
• W4285299212 cites W1954647396 @default.
• W4285299212 cites W1967191398 @default.
• W4285299212 cites W1969360633 @default.
• W4285299212 cites W19704530 @default.
• W4285299212 cites W1977851521 @default.
• W4285299212 cites W1981574419 @default.
• W4285299212 cites W1983562528 @default.
• W4285299212 cites W1987776440 @default.
• W4285299212 cites W1988093796 @default.
• W4285299212 cites W1989358544 @default.
• W4285299212 cites W1990170643 @default.
• W4285299212 cites W1996432520 @default.
• W4285299212 cites W2006875894 @default.
• W4285299212 cites W2010617308 @default.
• W4285299212 cites W2011679824 @default.
• W4285299212 cites W2017376990 @default.
• W4285299212 cites W2019756138 @default.
• W4285299212 cites W2023950788 @default.
• W4285299212 cites W2024921655 @default.
• W4285299212 cites W2039932426 @default.
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• W4285299212 cites W2059034059 @default.
• W4285299212 cites W2064123882 @default.
• W4285299212 cites W2080063584 @default.
• W4285299212 cites W2080627708 @default.
• W4285299212 cites W2087721664 @default.
• W4285299212 cites W2101444285 @default.
• W4285299212 cites W2105391176 @default.
• W4285299212 cites W2114524747 @default.
• W4285299212 cites W2117087393 @default.
• W4285299212 cites W2120773280 @default.
• W4285299212 cites W2137577190 @default.
• W4285299212 cites W2145904962 @default.
• W4285299212 cites W2165201727 @default.
• W4285299212 cites W2168457230 @default.
• W4285299212 cites W2314630053 @default.
• W4285299212 cites W2322485302 @default.
• W4285299212 cites W2326418539 @default.
• W4285299212 cites W2332035638 @default.
• W4285299212 cites W2412145118 @default.
• W4285299212 cites W2478185850 @default.
• W4285299212 cites W2478846246 @default.
• W4285299212 cites W2575532686 @default.
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• W4285299212 cites W2976104256 @default.
• W4285299212 cites W2976965014 @default.
• W4285299212 cites W2978865218 @default.
• W4285299212 cites W2996530972 @default.
• W4285299212 cites W3021909056 @default.
• W4285299212 cites W3025057078 @default.
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• W4285299212 cites W3086596505 @default.
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• W4285299212 doi "https://doi.org/10.1039/d2dt01251k" @default.
• W4285299212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35822497" @default.
• W4285299212 hasPublicationYear "2022" @default.
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