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- W4285307170 abstract "Endothelial dysfunction occurs early in the development of atherosclerosis and predicts the development of cardiovascular events in T2DM. The identification of patients with preclinical atherosclerosis allows for risk stratification and targeted intervention for primary prevention. The use of circulating biomarkers of endothelial function is a promising alternative for clinical use, in comparison to vasomotor techniques described in the previous chapter, which are more cumbersome and operator-dependent. This chapter describes the measurement of circulatory biomarkers of endothelial function and their evidence for use in T2DM. Of these, high-sensitivity CRP is currently the most utilized and validated serum biomarker for cardiovascular risk stratification, while other circulating biomarkers such as asymmetric dimethylarginine, VCAM-1, ICAM-1, advanced glycosylation end products, circulating endothelial progenitor cells, endothelial microparticles, and endocan hold promise as novel biomarkers of different aspects of endothelial dysfunction in T2DM, provided their quantification can be standardized and validated. Lastly, we highlight the use of external counterpulsation as an example of a therapeutic modality that can be employed to modulate these measures of endothelial function.KeywordsEndothelial dysfunctionDiabetesCardiovascular riskCirculatory biomarkersNitric oxideAsymmetric dimethylarginineHigh-sensitivity CRPAdvanced glycosylation end productsAdhesion moleculesEndothelial progenitor cellsEndothelial microparticlesExternal counterpulsation" @default.
- W4285307170 created "2022-07-14" @default.
- W4285307170 creator A5018430882 @default.
- W4285307170 date "2022-01-01" @default.
- W4285307170 modified "2023-09-28" @default.
- W4285307170 title "Measures of Endothelial Function in Type 2 Diabetes: A Focus on Circulatory Biomarkers" @default.
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