Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285308296> ?p ?o ?g. }
- W4285308296 endingPage "175883592210950" @default.
- W4285308296 startingPage "175883592210950" @default.
- W4285308296 abstract "Ovarian carcinoma is extremely sensitive to (platinum-based) chemotherapy; however, most patients will relapse with platinum-resistant disease, badly affecting their prognosis. Effective therapies for relapsing resistant tumors are urgently needed.We used patient-derived xenografts (PDXs) of ovarian carcinoma resistant to cisplatin (DDP) to test in vivo the combination of paclitaxel (15 mg/kg i.v. once a week for 3 weeks) and onvansertib, a plk1 inhibitor, (50 mg/kg orally 4 days a week for 3 weeks). The PDX models were subcutaneously (s.c.) or orthotopically transplanted in nude mice and antitumor efficacy was evaluated as tumor growth inhibition and survival advantages of the combination over untreated and single agent treatment.The combination of onvansertib and paclitaxel was very well tolerated with weight loss no greater than 15% in the combination group compared with the control group. In the orthotopically transplanted PDXs, single onvansertib and paclitaxel treatments prolonged survival; however, the combined treatment was much more active, with median survival from three- to six-fold times that of untreated mice. Findings were similar with the s.c. transplanted PDX, though there was greater heterogeneity in tumor response. Ex vivo tumors treated with the combination showed greater induction of γH2AX, marker of apoptosis and DNA damage, and pSer10H3, a marker of mitotic block.The efficacy of onvansertib and paclitaxel combination in these preclinical ovarian cancer models supports the clinical translatability of this combination as an effective therapeutic approach for platinum-resistant high-grade ovarian carcinoma." @default.
- W4285308296 created "2022-07-14" @default.
- W4285308296 creator A5000422869 @default.
- W4285308296 creator A5003109423 @default.
- W4285308296 creator A5023757905 @default.
- W4285308296 creator A5038885031 @default.
- W4285308296 creator A5052285902 @default.
- W4285308296 creator A5063654659 @default.
- W4285308296 creator A5065551274 @default.
- W4285308296 creator A5067892164 @default.
- W4285308296 creator A5070509354 @default.
- W4285308296 creator A5071752028 @default.
- W4285308296 date "2022-01-01" @default.
- W4285308296 modified "2023-09-25" @default.
- W4285308296 title "Onvansertib and paclitaxel combined in platinum-resistant ovarian carcinomas" @default.
- W4285308296 cites W127046385 @default.
- W4285308296 cites W132905495 @default.
- W4285308296 cites W1537737236 @default.
- W4285308296 cites W1914367223 @default.
- W4285308296 cites W1951421707 @default.
- W4285308296 cites W2019494208 @default.
- W4285308296 cites W2020582501 @default.
- W4285308296 cites W2037874673 @default.
- W4285308296 cites W2042119456 @default.
- W4285308296 cites W2047521557 @default.
- W4285308296 cites W2054558227 @default.
- W4285308296 cites W2101379344 @default.
- W4285308296 cites W2113631881 @default.
- W4285308296 cites W2123244616 @default.
- W4285308296 cites W2123696077 @default.
- W4285308296 cites W2125898467 @default.
- W4285308296 cites W2130659669 @default.
- W4285308296 cites W2140364596 @default.
- W4285308296 cites W2146212019 @default.
- W4285308296 cites W2167831982 @default.
- W4285308296 cites W2179105349 @default.
- W4285308296 cites W2235393999 @default.
- W4285308296 cites W2549761003 @default.
- W4285308296 cites W2560862072 @default.
- W4285308296 cites W2737358433 @default.
- W4285308296 cites W2766420394 @default.
- W4285308296 cites W2767793022 @default.
- W4285308296 cites W2787266690 @default.
- W4285308296 cites W2796889011 @default.
- W4285308296 cites W2889866656 @default.
- W4285308296 cites W2896925652 @default.
- W4285308296 cites W2908832432 @default.
- W4285308296 cites W2911188335 @default.
- W4285308296 cites W2919506079 @default.
- W4285308296 cites W2921219123 @default.
- W4285308296 cites W2945357020 @default.
- W4285308296 cites W2951641846 @default.
- W4285308296 cites W2959128319 @default.
- W4285308296 cites W2967385194 @default.
- W4285308296 cites W2990982401 @default.
- W4285308296 cites W2992603589 @default.
- W4285308296 cites W2998039482 @default.
- W4285308296 cites W3011759723 @default.
- W4285308296 cites W3016159100 @default.
- W4285308296 cites W3023274953 @default.
- W4285308296 cites W3036364440 @default.
- W4285308296 cites W3081238054 @default.
- W4285308296 cites W3090522151 @default.
- W4285308296 cites W3106363457 @default.
- W4285308296 cites W3208481219 @default.
- W4285308296 cites W749488837 @default.
- W4285308296 doi "https://doi.org/10.1177/17588359221095064" @default.
- W4285308296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35665077" @default.
- W4285308296 hasPublicationYear "2022" @default.
- W4285308296 type Work @default.
- W4285308296 citedByCount "0" @default.
- W4285308296 crossrefType "journal-article" @default.
- W4285308296 hasAuthorship W4285308296A5000422869 @default.
- W4285308296 hasAuthorship W4285308296A5003109423 @default.
- W4285308296 hasAuthorship W4285308296A5023757905 @default.
- W4285308296 hasAuthorship W4285308296A5038885031 @default.
- W4285308296 hasAuthorship W4285308296A5052285902 @default.
- W4285308296 hasAuthorship W4285308296A5063654659 @default.
- W4285308296 hasAuthorship W4285308296A5065551274 @default.
- W4285308296 hasAuthorship W4285308296A5067892164 @default.
- W4285308296 hasAuthorship W4285308296A5070509354 @default.
- W4285308296 hasAuthorship W4285308296A5071752028 @default.
- W4285308296 hasBestOaLocation W42853082961 @default.
- W4285308296 hasConcept C121608353 @default.
- W4285308296 hasConcept C126322002 @default.
- W4285308296 hasConcept C143998085 @default.
- W4285308296 hasConcept C150903083 @default.
- W4285308296 hasConcept C207001950 @default.
- W4285308296 hasConcept C2776694085 @default.
- W4285308296 hasConcept C2776999253 @default.
- W4285308296 hasConcept C2777292972 @default.
- W4285308296 hasConcept C2777546739 @default.
- W4285308296 hasConcept C2778239845 @default.
- W4285308296 hasConcept C2780427987 @default.
- W4285308296 hasConcept C2781451048 @default.
- W4285308296 hasConcept C3019054536 @default.
- W4285308296 hasConcept C3019864225 @default.
- W4285308296 hasConcept C502942594 @default.