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- W4285326098 abstract "Abstract By general consensus, the first-line treatment for trigeminal neuralgia is pharmacological. The two first drugs of choice are carbamazepine and oxcarbazepine, both voltage-gated sodium channel blockers that stabilize the hyperexcited neural membrane and inhibit repetitive firing. Although highly effective in controlling trigeminal neuralgia paroxysms, they are frequently discontinued because of sedative and cognitive side effects. Vixotrigine, a new sodium channel blocker that is selective for the Nav1.7 receptor, has shown promising efficacy without inducing side effects in a phase II trial and is awaiting pivotal clinical trials. If the first-line drugs fail to provide sufficient pain relief or are poorly tolerated, lamotrigine, baclofen, gabapentin, pregabalin, and botulinum toxin type A may be considered either alone or as add-on therapy. During acute exacerbations, in-hospital treatment may be necessary for rehydration, titration of drugs, and, in selected cases, lidocaine or fosphenytoin intravenous infusion, under cardiac monitoring." @default.
- W4285326098 created "2022-07-14" @default.
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- W4285326098 date "2021-12-01" @default.
- W4285326098 modified "2023-09-26" @default.
- W4285326098 title "Treatment of trigeminal neuralgia: Pharmacological" @default.
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- W4285326098 doi "https://doi.org/10.1093/med/9780198871606.003.0009" @default.
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