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- W4285328150 abstract "Gastric cancer prevention has been neglected for decades since the prevalence of H. pylori infection, a major cause of gastric cancer, is decreasing in many parts of the world. Nevertheless, as a result of demographic changes, the absolute number of new cases are expected to grow to 1.77 million in 2040 despite the decreasing overall incidence. The burden of gastric cancer can be decreased either by lowering the prevalence of H. pylori or by timely identification of precancerous lesions and surveillance of subjects identified with high-risk lesions. Population-based detection and eradication of H. pylori for prevention (‘screen-and-treat-strategy’) has been recommended by several guidelines (Taipei global consensus), yet no country has implemented the strategy so far. Similarly, pepsinogen testing has been extensively studied as a non-invasive tool for gastric mucosal atrophy detection, however is not included in any of the population-based gastric cancer prevention programs globally. None of the proposed methods for gastric cancer screening has shown decreasing gastric cancer mortality in clinical trials. A multicentric randomised study of H. pylori eradication and pepsinogen testing for prevention of gastric cancer mortality (GISTAR study) has been designed in collaboration between the University of Latvia and the International Agency for Research on Cancer (IARC). The recruitment has been started in 2013, and is ongoing. The enrolment of 10,000 study subjects has been recently achieved from 10 study sites in Latvia. The study design allows evaluation of new biomarkers and risk factors for cancer development. This includes research on cancer-related breath volatile markers as well as gut microbiota. Finally, Gastric cancer data collaborative proposed for the GAIA-X platform of European Commission is expected to facilitate the exchange of data for gastric cancer prevention in the European context." @default.
- W4285328150 created "2022-07-14" @default.
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- W4285328150 date "2021-12-01" @default.
- W4285328150 modified "2023-09-23" @default.
- W4285328150 title "Gastric cancer prevention. The GISTAR study" @default.
- W4285328150 doi "https://doi.org/10.1097/01.cej.0000816660.62751.fb" @default.
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