Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285332024> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W4285332024 abstract "This study reports a reconfigurable microfluidic platform comprising multifunctional building blocks and interfaces for high-throughput screening of nonhormonal contraceptives. The platform has three layers of microfluidic building blocks. The top layer consists of interchangeable microchannel building blocks in 3D for liquid handling (e.g., compound libraries, chemical concentration gradients, and drug cocktail mixers). The middle layer incorporates a multiwell array with embedded membrane filters for oocyte culture, medium exchange, enzymatic cumulus cell removal, washing, and fluorescence staining. The bottom layer can be reconfigured for waste collection, oocyte culture, and high-resolution microscopy. The reconfigurability of the platform is enabled by reversible and robust elastomer-based interconnects between building blocks. We demonstrate the platform for performing contraceptive drug loading, in situ oocyte incubation, enzymatic cumulus cell digestion, fluorescence staining, and on-chip imaging in a cumulusoocyte complex (COC) expansion assay for screening nonhormonal contraceptives." @default.
- W4285332024 created "2022-07-14" @default.
- W4285332024 creator A5008046306 @default.
- W4285332024 creator A5011948157 @default.
- W4285332024 creator A5043107998 @default.
- W4285332024 creator A5078597560 @default.
- W4285332024 date "2021-11-15" @default.
- W4285332024 modified "2023-09-26" @default.
- W4285332024 title "A Reconfigurable Microfluidic Building Block Platform for High-Throughput Nonhormonal Contraceptive Screening" @default.
- W4285332024 doi "https://doi.org/10.1109/nanomed54179.2021.9766590" @default.
- W4285332024 hasPublicationYear "2021" @default.
- W4285332024 type Work @default.
- W4285332024 citedByCount "0" @default.
- W4285332024 crossrefType "proceedings-article" @default.
- W4285332024 hasAuthorship W4285332024A5008046306 @default.
- W4285332024 hasAuthorship W4285332024A5011948157 @default.
- W4285332024 hasAuthorship W4285332024A5043107998 @default.
- W4285332024 hasAuthorship W4285332024A5078597560 @default.
- W4285332024 hasBestOaLocation W42853320242 @default.
- W4285332024 hasConcept C127413603 @default.
- W4285332024 hasConcept C136229726 @default.
- W4285332024 hasConcept C157764524 @default.
- W4285332024 hasConcept C171250308 @default.
- W4285332024 hasConcept C185592680 @default.
- W4285332024 hasConcept C192562407 @default.
- W4285332024 hasConcept C196843134 @default.
- W4285332024 hasConcept C2776690073 @default.
- W4285332024 hasConcept C2780149590 @default.
- W4285332024 hasConcept C41008148 @default.
- W4285332024 hasConcept C555944384 @default.
- W4285332024 hasConcept C76155785 @default.
- W4285332024 hasConcept C8673954 @default.
- W4285332024 hasConcept C86803240 @default.
- W4285332024 hasConcept C9390403 @default.
- W4285332024 hasConcept C95444343 @default.
- W4285332024 hasConceptScore W4285332024C127413603 @default.
- W4285332024 hasConceptScore W4285332024C136229726 @default.
- W4285332024 hasConceptScore W4285332024C157764524 @default.
- W4285332024 hasConceptScore W4285332024C171250308 @default.
- W4285332024 hasConceptScore W4285332024C185592680 @default.
- W4285332024 hasConceptScore W4285332024C192562407 @default.
- W4285332024 hasConceptScore W4285332024C196843134 @default.
- W4285332024 hasConceptScore W4285332024C2776690073 @default.
- W4285332024 hasConceptScore W4285332024C2780149590 @default.
- W4285332024 hasConceptScore W4285332024C41008148 @default.
- W4285332024 hasConceptScore W4285332024C555944384 @default.
- W4285332024 hasConceptScore W4285332024C76155785 @default.
- W4285332024 hasConceptScore W4285332024C8673954 @default.
- W4285332024 hasConceptScore W4285332024C86803240 @default.
- W4285332024 hasConceptScore W4285332024C9390403 @default.
- W4285332024 hasConceptScore W4285332024C95444343 @default.
- W4285332024 hasLocation W42853320241 @default.
- W4285332024 hasLocation W42853320242 @default.
- W4285332024 hasOpenAccess W4285332024 @default.
- W4285332024 hasPrimaryLocation W42853320241 @default.
- W4285332024 hasRelatedWork W2125519019 @default.
- W4285332024 hasRelatedWork W2152033542 @default.
- W4285332024 hasRelatedWork W2205537179 @default.
- W4285332024 hasRelatedWork W2748952813 @default.
- W4285332024 hasRelatedWork W2798116268 @default.
- W4285332024 hasRelatedWork W2899084033 @default.
- W4285332024 hasRelatedWork W2981091105 @default.
- W4285332024 hasRelatedWork W4200507794 @default.
- W4285332024 hasRelatedWork W4206653844 @default.
- W4285332024 hasRelatedWork W4385923988 @default.
- W4285332024 isParatext "false" @default.
- W4285332024 isRetracted "false" @default.
- W4285332024 workType "article" @default.