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- W4285343762 abstract "Repetitive mild traumatic brain injury, commonly experienced following sports injuries, results in various secondary injury processes and is increasingly recognised as a risk factor for the development of neurodegenerative conditions such as chronic traumatic encephalopathy, a progressive neurodegenerative disorder characterised by tau pathology. We aimed to characterise the underlying pathological mechanisms that might contribute to the onset of neurodegeneration and behavioural changes in the less-explored sub-acute (1-month) period following single or repetitive controlled cortical impact injury (5 impacts, 48h apart) in 12-week old male and female C57Bl6 mice. We performed motor and cognitive tests, extensively characterised the status of tau and it’s regulatory proteins via western blot and used unbiased stereology to quantify neuronal cell populations. We report that five impacts resulted in prolonged neurobehavioural deficits, motor impairments and anxiety-like behaviour up to 1-month post-injury, effects not seen following a single injury. Five impacts caused a significant increase in amyloid precursor protein, an increased trend towards tau phosphorylation and significant changes in kinase and phosphatase proteins which may promote a downstream increase in tau phosphorylation. Lastly, we describe marked neuronal loss following both single and repeat injuries. We demonstrate herein that repeated impacts are required to promote the initiation of a cascade of biochemical events that are consistent with the onset of neurodegeneration sub-acutely post-injury. Identifying the timeframe in which these changes occur and the pathological mechanisms involved will be crucial for the development of future therapeutics to prevent the onset or mitigate the progression of neurodegeneration following repeated injury." @default.
- W4285343762 created "2022-07-14" @default.
- W4285343762 creator A5001293004 @default.
- W4285343762 date "2021-10-22" @default.
- W4285343762 modified "2023-09-29" @default.
- W4285343762 title "Review for Altered amyloid precursor protein, tau‐regulatory proteins, neuronal numbers and behaviour, but no tau pathology, synaptic and inflammatory changes or memory deficits, at 1‐month following repetitive mild traumatic brain injury" @default.
- W4285343762 doi "https://doi.org/10.1111/ejn.15752/v1/review2" @default.
- W4285343762 hasPublicationYear "2021" @default.
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