FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285378102> ?p ?o ?g. }

• W4285378102 endingPage "80" @default.
• W4285378102 startingPage "69" @default.
• W4285378102 abstract "Chlorophytum alismifolium (C. alismifolium) tubers are used in the management of diabetes. This research evaluated the effect of ethylacetate extract of C. alismifolium (EACA) on microvascular complications and the possible association of oxidative stress and aldose reductase in type 2 diabetic rats.C. alismifolium tubers were subjected to sequential extraction until ethylacetate extract was obtained using a soxhlet apparatus. The LD50 was determined using the OECD 425 guideline. The animals were placed on high fat diet for 42 days and then induced with hyperglycaemia using 40 mg/kg of streptozotocin. Diabetic neuropathy was evaluated using thermal and mechanical methods. Serum was used for the assessment of oxidative stress markers and biochemical markers of retinopathy and nephropathy. Serum aldose reductase was investigated by utilizing the principle of enzyme-linked immunosorbent assay.The median lethal dose of EACA was assessed to be above 5,000 mg/kg and it caused no mortality. Treatment with EACA significantly reduced the withdrawal times in both thermal and mechanical hyperalgesic methods (p<0.05). EACA also significantly reduced the levels of urea (p<0.001), albumin (p<0.05) and uric acid (p<0.001) in hyperglycaemic rats. EACA significantly decreased the amounts of low density lipoprotein and triglycerides (p<0.001). There was a remarkable elevation in the levels of high density lipoprotein (p<0.05). A significant (p<0.05) increase in the levels of magnesium was observed in the EACA-treated groups. EACA significantly increased catalase (p<0.05) and reduced malondialdehyde levels (p<0.05). The levels of aldose reductase was significantly (p<0.001) reduced by EACA compared to the hyperglycaemic control.The ethylacetate extract of C. alismifolium has beneficial effects in alleviating microvascular complications of diabetes through the inhibition of oxidative stress and aldose reductase in diabetic rats." @default.
• W4285378102 created "2022-07-14" @default.
• W4285378102 creator A5005938722 @default.
• W4285378102 creator A5015931462 @default.
• W4285378102 creator A5040802872 @default.
• W4285378102 creator A5055347577 @default.
• W4285378102 creator A5064166945 @default.
• W4285378102 creator A5086464208 @default.
• W4285378102 date "2021-08-16" @default.
• W4285378102 modified "2023-09-26" @default.
• W4285378102 title "<i>Chlorophytum alismifolium</i> mitigates microvascular complications of type 2 diabetes mellitus: the involvement of oxidative stress and aldose reductase" @default.
• W4285378102 cites W1542467652 @default.
• W4285378102 cites W1673270816 @default.
• W4285378102 cites W1968144965 @default.
• W4285378102 cites W1970538359 @default.
• W4285378102 cites W1972017174 @default.
• W4285378102 cites W1977914448 @default.
• W4285378102 cites W1995138120 @default.
• W4285378102 cites W1995382021 @default.
• W4285378102 cites W1999647730 @default.
• W4285378102 cites W2006370393 @default.
• W4285378102 cites W2027300271 @default.
• W4285378102 cites W2033355709 @default.
• W4285378102 cites W2054259115 @default.
• W4285378102 cites W2056005657 @default.
• W4285378102 cites W2074652188 @default.
• W4285378102 cites W2087042369 @default.
• W4285378102 cites W2111599410 @default.
• W4285378102 cites W2113880168 @default.
• W4285378102 cites W2117101915 @default.
• W4285378102 cites W2124705447 @default.
• W4285378102 cites W2127013573 @default.
• W4285378102 cites W2132895884 @default.
• W4285378102 cites W2138432502 @default.
• W4285378102 cites W2160094922 @default.
• W4285378102 cites W2233224207 @default.
• W4285378102 cites W2278027467 @default.
• W4285378102 cites W2405585158 @default.
• W4285378102 cites W2428619446 @default.
• W4285378102 cites W2563941536 @default.
• W4285378102 cites W2615714795 @default.
• W4285378102 cites W2740555108 @default.
• W4285378102 cites W2762844085 @default.
• W4285378102 cites W2768429251 @default.
• W4285378102 cites W2779028451 @default.
• W4285378102 cites W2781073099 @default.
• W4285378102 cites W2782353721 @default.
• W4285378102 cites W2791517164 @default.
• W4285378102 cites W2800038406 @default.
• W4285378102 cites W2806671364 @default.
• W4285378102 cites W2886516169 @default.
• W4285378102 cites W2891039799 @default.
• W4285378102 cites W2900141214 @default.
• W4285378102 cites W2904775744 @default.
• W4285378102 cites W2912447088 @default.
• W4285378102 cites W2913817540 @default.
• W4285378102 cites W2918016846 @default.
• W4285378102 cites W2919042093 @default.
• W4285378102 cites W2920938998 @default.
• W4285378102 cites W2922116865 @default.
• W4285378102 cites W2924534120 @default.
• W4285378102 cites W2944544314 @default.
• W4285378102 cites W2946250439 @default.
• W4285378102 cites W2953997838 @default.
• W4285378102 cites W2970441691 @default.
• W4285378102 cites W2980328483 @default.
• W4285378102 cites W2996276372 @default.
• W4285378102 cites W3022807561 @default.
• W4285378102 cites W3038986389 @default.
• W4285378102 cites W3044935065 @default.
• W4285378102 cites W3094914540 @default.
• W4285378102 cites W4205407119 @default.
• W4285378102 cites W4211087088 @default.
• W4285378102 cites W987544560 @default.
• W4285378102 doi "https://doi.org/10.1515/dmpt-2021-0129" @default.
• W4285378102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35385895" @default.
• W4285378102 hasPublicationYear "2021" @default.
• W4285378102 type Work @default.
• W4285378102 citedByCount "0" @default.
• W4285378102 crossrefType "journal-article" @default.
• W4285378102 hasAuthorship W4285378102A5005938722 @default.
• W4285378102 hasAuthorship W4285378102A5015931462 @default.
• W4285378102 hasAuthorship W4285378102A5040802872 @default.
• W4285378102 hasAuthorship W4285378102A5055347577 @default.
• W4285378102 hasAuthorship W4285378102A5064166945 @default.
• W4285378102 hasAuthorship W4285378102A5086464208 @default.
• W4285378102 hasConcept C126322002 @default.
• W4285378102 hasConcept C134018914 @default.
• W4285378102 hasConcept C2776151105 @default.
• W4285378102 hasConcept C2776439734 @default.
• W4285378102 hasConcept C2777374081 @default.
• W4285378102 hasConcept C2778401633 @default.
• W4285378102 hasConcept C2779881121 @default.
• W4285378102 hasConcept C2781184683 @default.
• W4285378102 hasConcept C555293320 @default.
• W4285378102 hasConcept C71924100 @default.
• W4285378102 hasConceptScore W4285378102C126322002 @default.
• W4285378102 hasConceptScore W4285378102C134018914 @default.

• next