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- W4285379314 abstract "Farmakoterapie obezity u mnoha pacientĹŻ vede k vĂ˝znamnĂŠmu a dlouhodobÄ udrĹžitelnĂŠmu poklesu tÄlesnĂŠ hmotnosti a tĂm i zlepĹĄenĂ komorbidit a celkovĂŠ prognĂłzy. V souÄasnĂŠ dobÄ jsou v ÄR dostupnĂŠ pro terapii obezity celkem 4 lĂŠky: fentermin, orlistat, liraglutid a bupropion/naltrexon. Ve sdÄlenĂ se podrobnÄji vÄnujeme pĹedevĹĄĂm relativnÄ recentnÄ registrovanĂ˝m lĂŠÄivĹŻm (liraglutid a bupropion/naltrexon). KrĂĄtce zmiĹujeme i lĂŠky recentnÄ staĹženĂŠ z trhu (lorkaserin a rimonabant) a uvĂĄdĂme nejslibnÄjĹĄĂ molekuly v klinickĂŠm vĂ˝voji (tesofensin a bimagrumab). PĹi nastavovĂĄnĂ terapie na mĂru konkrĂŠtnĂmu pacientovi trpĂcĂmu obezitou bychom pro terapii pĹidruĹženĂ˝ch onemocnÄnĂ (diabetes, deprese) mÄli volit lĂŠky, kterĂŠ nezvyĹĄujĂ tÄlesnou hmotnost, a naopak lĂŠky, kterĂŠ pouĹžĂvĂĄme k terapii obezity, by mÄly bĂ˝t vybrĂĄny tak, aby nezhorĹĄovaly dalĹĄĂ choroby, kterĂ˝mi pacienti trpĂ." @default.
- W4285379314 created "2022-07-14" @default.
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- W4285379314 date "2021-08-05" @default.
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- W4285379314 title "Novel drugs in pharmacotherapy of obesity" @default.
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- W4285379314 doi "https://doi.org/10.36290/lek.2021.015" @default.
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