Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285384465> ?p ?o ?g. }
- W4285384465 endingPage "228" @default.
- W4285384465 startingPage "219" @default.
- W4285384465 abstract "To investigate the mechanism of Silent information regulator 1 (SIRT1) regulation of DNA methylation and thus the expression of synaptic plasticity-related genes induced by lead (Pb) exposure, the early-life Sprague-Dawley rats and PC12 cells were used to establish Pb exposure models and treated with SIRT1 agonists (resveratrol and SRT1720). In vivo results demonstrated that Pb exposure increased the expression of DNMTs, MeCP2, PP1 and cleaved caspase3, decreased the expression of SIRT1, BDNF and RELIN and altered DNA methylation levels of synaptic plasticity genes. Moreover, we observed marked pathological damage in the hippocampal CA1 region of the 0.2 % Pb-exposure group. After treatment with resveratrol, the effects of Pb exposure on the expression of the above molecules and pathological features were significantly ameliorated in the hippocampus of rats. In vitro results showed that after the treatment with SRT1720, the expression of SIRT1 was activated and thus reversed the effect on DNMTs, MeCP2, apoptosis and synaptic plasticity-related genes and their DNA methylation levels induced by Pb exposure. In conclusion, we validated the important protective role of SIRT1 in neurotoxicity induced by Pb exposure through in vivo and in vitro experiments, providing potential therapeutic targets for the treatment and prevention of brain damage." @default.
- W4285384465 created "2022-07-14" @default.
- W4285384465 creator A5012699438 @default.
- W4285384465 creator A5025382217 @default.
- W4285384465 creator A5028981234 @default.
- W4285384465 creator A5043174025 @default.
- W4285384465 creator A5045724389 @default.
- W4285384465 creator A5047288770 @default.
- W4285384465 creator A5060139382 @default.
- W4285384465 creator A5061117894 @default.
- W4285384465 creator A5075990181 @default.
- W4285384465 creator A5077341571 @default.
- W4285384465 creator A5081077843 @default.
- W4285384465 creator A5083818490 @default.
- W4285384465 date "2022-09-01" @default.
- W4285384465 modified "2023-10-17" @default.
- W4285384465 title "SIRT1 modifies DNA methylation linked to synaptic deficits induced by Pb in vitro and in vivo" @default.
- W4285384465 cites W1826885399 @default.
- W4285384465 cites W1900117997 @default.
- W4285384465 cites W1971925893 @default.
- W4285384465 cites W1979305117 @default.
- W4285384465 cites W2013230506 @default.
- W4285384465 cites W2030134162 @default.
- W4285384465 cites W2031379951 @default.
- W4285384465 cites W2033630913 @default.
- W4285384465 cites W2039954704 @default.
- W4285384465 cites W2054717478 @default.
- W4285384465 cites W205881385 @default.
- W4285384465 cites W2069252124 @default.
- W4285384465 cites W2075043109 @default.
- W4285384465 cites W2075812983 @default.
- W4285384465 cites W2076312647 @default.
- W4285384465 cites W2081429864 @default.
- W4285384465 cites W2113486281 @default.
- W4285384465 cites W2115818350 @default.
- W4285384465 cites W2116060378 @default.
- W4285384465 cites W2126088939 @default.
- W4285384465 cites W2129356204 @default.
- W4285384465 cites W2133093591 @default.
- W4285384465 cites W2137296349 @default.
- W4285384465 cites W2158512855 @default.
- W4285384465 cites W2298401972 @default.
- W4285384465 cites W2339030503 @default.
- W4285384465 cites W2344672625 @default.
- W4285384465 cites W2522138202 @default.
- W4285384465 cites W2523680272 @default.
- W4285384465 cites W2549852019 @default.
- W4285384465 cites W2558053133 @default.
- W4285384465 cites W2726353477 @default.
- W4285384465 cites W2753051071 @default.
- W4285384465 cites W2764258435 @default.
- W4285384465 cites W2790231974 @default.
- W4285384465 cites W2801465118 @default.
- W4285384465 cites W2806360461 @default.
- W4285384465 cites W2890410745 @default.
- W4285384465 cites W2901734506 @default.
- W4285384465 cites W2902414463 @default.
- W4285384465 cites W2934806320 @default.
- W4285384465 cites W2947355008 @default.
- W4285384465 cites W2979603411 @default.
- W4285384465 cites W2981164036 @default.
- W4285384465 cites W3088489717 @default.
- W4285384465 cites W3105869999 @default.
- W4285384465 cites W3113172355 @default.
- W4285384465 cites W3137764892 @default.
- W4285384465 cites W3141475720 @default.
- W4285384465 cites W3162762815 @default.
- W4285384465 cites W3175076221 @default.
- W4285384465 cites W3183463006 @default.
- W4285384465 cites W4221041079 @default.
- W4285384465 doi "https://doi.org/10.1016/j.ijbiomac.2022.07.060" @default.
- W4285384465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35839949" @default.
- W4285384465 hasPublicationYear "2022" @default.
- W4285384465 type Work @default.
- W4285384465 citedByCount "7" @default.
- W4285384465 countsByYear W42853844652022 @default.
- W4285384465 countsByYear W42853844652023 @default.
- W4285384465 crossrefType "journal-article" @default.
- W4285384465 hasAuthorship W4285384465A5012699438 @default.
- W4285384465 hasAuthorship W4285384465A5025382217 @default.
- W4285384465 hasAuthorship W4285384465A5028981234 @default.
- W4285384465 hasAuthorship W4285384465A5043174025 @default.
- W4285384465 hasAuthorship W4285384465A5045724389 @default.
- W4285384465 hasAuthorship W4285384465A5047288770 @default.
- W4285384465 hasAuthorship W4285384465A5060139382 @default.
- W4285384465 hasAuthorship W4285384465A5061117894 @default.
- W4285384465 hasAuthorship W4285384465A5075990181 @default.
- W4285384465 hasAuthorship W4285384465A5077341571 @default.
- W4285384465 hasAuthorship W4285384465A5081077843 @default.
- W4285384465 hasAuthorship W4285384465A5083818490 @default.
- W4285384465 hasConcept C104317684 @default.
- W4285384465 hasConcept C127561419 @default.
- W4285384465 hasConcept C134018914 @default.
- W4285384465 hasConcept C143425029 @default.
- W4285384465 hasConcept C148762608 @default.
- W4285384465 hasConcept C150194340 @default.
- W4285384465 hasConcept C153911025 @default.
- W4285384465 hasConcept C170493617 @default.