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• W4285384588 endingPage "113256" @default.
• W4285384588 startingPage "113256" @default.
• W4285384588 abstract "Punica granatum L (pomegranate) is one of the Mediterranean medicinal plants that has been used for generations in treating ulcers, diarrhea, and male infertility. Increasing evidence has revealed that pomegranate possesses myriads of pharmacological activities such as anti-diabetic, anti-tumor, anti-inflammatory, anti-malaria, anti-fibrotic, anti-fungal, anti-bacterial, and other effects. Consumption of pomegranate could be used to improve gut microbiota, and therefore prevent obesity and diabetes. The mechanisms of actions of pomegranate, mainly involve nuclear factor-erythroid factor 2-related factor 2 (Nrf2), nuclear factor kappa B (NF-kB), and mitogen-activated protein kinase (MAPK) signaling pathways. In recent times, in silico molecular docking studies demonstrated that pomegranate extract and or its phytochemicals are potential inhibitors of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) spike protein and angiotensin-converting enzyme 2 (ACE2) receptor contact. Also, some clinical trials have indicated that pomegranate can be consumed for alleviation of non-alcoholic fatty liver disease, metabolic syndrome, dental infections, and menopausal symptoms. To date, active compounds, viz. alkaloids, anthocyanidins, tannins, flavonoids, phenolics, proanthocyanidins, sterols, terpenes, terpenoids, xanthonoids, fatty acids, organic acids, lignans, saccharides, and vitamin C have been isolated from pomegranate. Therefore, the current review article aimed to gather and presents an update on the ethnomedicinal uses, pharmacological activities, phytochemistry, and molecular mechanisms of Punica granatum L. This knowledge is of paramount importance in the future in drug discovery for the development of novel natural drugs for the treatment of various ailments." @default.
• W4285384588 created "2022-07-14" @default.
• W4285384588 creator A5018863848 @default.
• W4285384588 creator A5020575941 @default.
• W4285384588 creator A5047795343 @default.
• W4285384588 creator A5060929633 @default.
• W4285384588 creator A5070863910 @default.
• W4285384588 date "2022-09-01" @default.
• W4285384588 modified "2023-10-14" @default.
• W4285384588 title "Medicinal uses, pharmacological activities, phytochemistry, and the molecular mechanisms of Punica granatum L. (pomegranate) plant extracts: A review" @default.
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