FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285384764> ?p ?o ?g. }

• W4285384764 endingPage "100592" @default.
• W4285384764 startingPage "100592" @default.
• W4285384764 abstract "The contribution of colostrum to passive immunity transfer and intestinal protection in newborn ruminants is well known; however, it is currently unclear how colostrum intake affects intestinal innate immunity. We investigated the effects of bovine colostrum intake on ileal morphology, expression of genes involved in intestinal innate immunity, and serum concentrations of inflammatory cytokines in newborn lambs. Twenty-seven newborn male Hu lambs were used, of which 18 were bottle-fed either bovine colostrum (C24h; n = 9) or bovine mature milk (M24h; n = 9) within the first 2 h after birth at an intake of approximately 8% of BW; the remaining nine lambs did not receive any feeding (N24h). Blood and ileal tissue samples were collected after the lambs were slaughtered at 24 h after birth. Ileal villus height and villus height-to-crypt depth ratio were significantly higher in C24h than those in N24h and M24h lambs (P < 0.01). Messenger RNA (mRNA) abundance of toll-like receptor (TLR)-2, TLR3, TLR4, TLR6, TLR7, TLR8 and tumour necrosis factor alpha in the ileum was lower in C24h than that in N24h lambs (P < 0.05). Moreover, C24h lambs had a lower TLR3 mRNA abundance (P < 0.01) and a trend of lower TLR6 (P = 0.06) and interleukin 1 beta (P = 0.08) expression compared with those in M24h lambs. We also observed strong positive correlations of tumour necrosis factor alpha expression with that of TLR2 (r = 0.71; P < 0.001), TLR4 (r = 0.88; P < 0.001) and TLR8 (r = 0.83; P < 0.001). Interestingly, the expression of barrier-related molecules, including mucin-13, lysozyme, claudin (CLDN)-1, CLDN2, CLDN4, CLDN7, CLDN12, occludin, zonula occluden-1 and junctional adhesion molecule-1, was consistently lower in C24h lambs than that in N24h and M24h lambs (P < 0.05). These results indicated that the beneficial roles of colostrum intake on intestinal protection in newborn lambs were associated with low TLR expression, which was reflected by improved intestinal development and reduced inflammatory response. Further studies using fluorescence in situ hybridisation and immunohistochemical methods are needed to further explore the mechanisms underlying the lower expression of intestinal barrier-related molecules due to colostrum feeding." @default.
• W4285384764 created "2022-07-14" @default.
• W4285384764 creator A5000886352 @default.
• W4285384764 creator A5002319878 @default.
• W4285384764 creator A5012195101 @default.
• W4285384764 creator A5015134731 @default.
• W4285384764 creator A5035104121 @default.
• W4285384764 creator A5040047969 @default.
• W4285384764 creator A5041436745 @default.
• W4285384764 creator A5044063337 @default.
• W4285384764 creator A5067166045 @default.
• W4285384764 creator A5076595884 @default.
• W4285384764 date "2022-08-01" @default.
• W4285384764 modified "2023-10-14" @default.
• W4285384764 title "Bovine colostrum promoted ileal health in newborn lambs at 24 h after birth: insight from intestinal morphology and innate immunity" @default.
• W4285384764 cites W1647732753 @default.
• W4285384764 cites W1887722478 @default.
• W4285384764 cites W1966214546 @default.
• W4285384764 cites W1973067432 @default.
• W4285384764 cites W1985028619 @default.
• W4285384764 cites W1990379298 @default.
• W4285384764 cites W2003990440 @default.
• W4285384764 cites W2013121540 @default.
• W4285384764 cites W2035981279 @default.
• W4285384764 cites W2045890917 @default.
• W4285384764 cites W2046478575 @default.
• W4285384764 cites W2054050862 @default.
• W4285384764 cites W2055959752 @default.
• W4285384764 cites W2062225820 @default.
• W4285384764 cites W2071749331 @default.
• W4285384764 cites W2078957915 @default.
• W4285384764 cites W2082732215 @default.
• W4285384764 cites W2092719129 @default.
• W4285384764 cites W2102442544 @default.
• W4285384764 cites W2102447228 @default.
• W4285384764 cites W2106694537 @default.
• W4285384764 cites W2111227303 @default.
• W4285384764 cites W2135249518 @default.
• W4285384764 cites W2135268699 @default.
• W4285384764 cites W2145189896 @default.
• W4285384764 cites W2146956574 @default.
• W4285384764 cites W2156868373 @default.
• W4285384764 cites W2167090556 @default.
• W4285384764 cites W2221807962 @default.
• W4285384764 cites W2257718622 @default.
• W4285384764 cites W2476875329 @default.
• W4285384764 cites W2509842739 @default.
• W4285384764 cites W2515742810 @default.
• W4285384764 cites W2516565347 @default.
• W4285384764 cites W2589573619 @default.
• W4285384764 cites W2597760243 @default.
• W4285384764 cites W2787320471 @default.
• W4285384764 cites W2801807780 @default.
• W4285384764 cites W2809409444 @default.
• W4285384764 cites W2895502224 @default.
• W4285384764 cites W2896068050 @default.
• W4285384764 cites W2910114164 @default.
• W4285384764 cites W3004619508 @default.
• W4285384764 cites W3004735230 @default.
• W4285384764 cites W3012283572 @default.
• W4285384764 cites W3013333030 @default.
• W4285384764 cites W3034841120 @default.
• W4285384764 cites W3046247904 @default.
• W4285384764 cites W3096886706 @default.
• W4285384764 cites W3160494052 @default.
• W4285384764 cites W317027752 @default.
• W4285384764 cites W3178679011 @default.
• W4285384764 doi "https://doi.org/10.1016/j.animal.2022.100592" @default.
• W4285384764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35841825" @default.
• W4285384764 hasPublicationYear "2022" @default.
• W4285384764 type Work @default.
• W4285384764 citedByCount "3" @default.
• W4285384764 countsByYear W42853847642022 @default.
• W4285384764 countsByYear W42853847642023 @default.
• W4285384764 crossrefType "journal-article" @default.
• W4285384764 hasAuthorship W4285384764A5000886352 @default.
• W4285384764 hasAuthorship W4285384764A5002319878 @default.
• W4285384764 hasAuthorship W4285384764A5012195101 @default.
• W4285384764 hasAuthorship W4285384764A5015134731 @default.
• W4285384764 hasAuthorship W4285384764A5035104121 @default.
• W4285384764 hasAuthorship W4285384764A5040047969 @default.
• W4285384764 hasAuthorship W4285384764A5041436745 @default.
• W4285384764 hasAuthorship W4285384764A5044063337 @default.
• W4285384764 hasAuthorship W4285384764A5067166045 @default.
• W4285384764 hasAuthorship W4285384764A5076595884 @default.
• W4285384764 hasBestOaLocation W42853847641 @default.
• W4285384764 hasConcept C126322002 @default.
• W4285384764 hasConcept C134018914 @default.
• W4285384764 hasConcept C136449434 @default.
• W4285384764 hasConcept C159654299 @default.
• W4285384764 hasConcept C16685009 @default.
• W4285384764 hasConcept C203014093 @default.
• W4285384764 hasConcept C2777226302 @default.
• W4285384764 hasConcept C2779073587 @default.
• W4285384764 hasConcept C2779341262 @default.
• W4285384764 hasConcept C2781236682 @default.
• W4285384764 hasConcept C71924100 @default.
• W4285384764 hasConcept C86803240 @default.

• next