Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285386481> ?p ?o ?g. }
- W4285386481 abstract "Aging-related retinal degeneration can manifest as decreased visual function due to damage to retinal structures and dysfunction in retinal homeostasis. Naringenin, a flavonoid, has beneficial effects in preventing cellular aging, preserving the functionality of photoreceptors, and slowing down visual function loss. However, the role and potential mechanism of naringenin in the aging mouse retina require further investigation. In this study, we evaluated the effects of naringenin on the aging eye using electroretinogram (ERG) and hematoxylin and eosin staining and explored its potential mechanism by western blotting. ERG showed that naringenin increased the amplitude of the a- and b-waves of scotopic 3.0, 10.0, and the a-wave amplitude of photopic 3.0 in the aging mouse retina. Furthermore, administration of naringenin prevented aging-induced retinal degeneration in the total retina, ganglion cell, inner plexiform layer, inner nuclear layer, and outer nuclear layer. The expression of mitochondrial fusion protein two was increased, OPA1 protein expression and the ratio of L-OPA1/S-OPA1 were unchanged, and dynamin-related protein one was decreased in the 12-month-old mice treated with naringenin compared with the 12-month-old mice treated with vehicle. Furthermore, the downregulation of age-related alterations in autophagy was significantly rescued in the aging mice by treatment with naringenin. Taken together, these results suggest that the oral administration of naringenin improves visual function, retinal structure, mitochondrial dynamics, and autophagy in the aging mouse retinas. Naringenin may be a potential dietary supplement for the prevention or treatment of aging-related retinal degeneration." @default.
- W4285386481 created "2022-07-14" @default.
- W4285386481 creator A5013972114 @default.
- W4285386481 creator A5017763740 @default.
- W4285386481 creator A5026043177 @default.
- W4285386481 creator A5041432535 @default.
- W4285386481 creator A5073568638 @default.
- W4285386481 creator A5077420983 @default.
- W4285386481 creator A5088465003 @default.
- W4285386481 date "2022-07-14" @default.
- W4285386481 modified "2023-10-05" @default.
- W4285386481 title "Long-term oral administration of naringenin counteracts aging-related retinal degeneration via regulation of mitochondrial dynamics and autophagy" @default.
- W4285386481 cites W1735326722 @default.
- W4285386481 cites W1850657797 @default.
- W4285386481 cites W1944215271 @default.
- W4285386481 cites W1980798684 @default.
- W4285386481 cites W2019455536 @default.
- W4285386481 cites W2045337521 @default.
- W4285386481 cites W2054580728 @default.
- W4285386481 cites W2060792177 @default.
- W4285386481 cites W2084571636 @default.
- W4285386481 cites W2139636031 @default.
- W4285386481 cites W2229506676 @default.
- W4285386481 cites W2546015443 @default.
- W4285386481 cites W2559703789 @default.
- W4285386481 cites W2562358208 @default.
- W4285386481 cites W2588300742 @default.
- W4285386481 cites W2594208253 @default.
- W4285386481 cites W2618398139 @default.
- W4285386481 cites W2750385889 @default.
- W4285386481 cites W2759633738 @default.
- W4285386481 cites W2795845448 @default.
- W4285386481 cites W2886053196 @default.
- W4285386481 cites W2894990543 @default.
- W4285386481 cites W2897831960 @default.
- W4285386481 cites W2902346017 @default.
- W4285386481 cites W2944120685 @default.
- W4285386481 cites W2945272173 @default.
- W4285386481 cites W2963984502 @default.
- W4285386481 cites W2969048466 @default.
- W4285386481 cites W2988304170 @default.
- W4285386481 cites W2988319557 @default.
- W4285386481 cites W2995118259 @default.
- W4285386481 cites W2995359770 @default.
- W4285386481 cites W3002184305 @default.
- W4285386481 cites W3047016564 @default.
- W4285386481 cites W3087165374 @default.
- W4285386481 cites W3088186339 @default.
- W4285386481 cites W3092335062 @default.
- W4285386481 cites W3111367366 @default.
- W4285386481 cites W3114852515 @default.
- W4285386481 cites W3134288213 @default.
- W4285386481 cites W3137113311 @default.
- W4285386481 cites W3152484642 @default.
- W4285386481 cites W57491276 @default.
- W4285386481 cites W591839811 @default.
- W4285386481 doi "https://doi.org/10.3389/fphar.2022.919905" @default.
- W4285386481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35910364" @default.
- W4285386481 hasPublicationYear "2022" @default.
- W4285386481 type Work @default.
- W4285386481 citedByCount "5" @default.
- W4285386481 countsByYear W42853864812023 @default.
- W4285386481 crossrefType "journal-article" @default.
- W4285386481 hasAuthorship W4285386481A5013972114 @default.
- W4285386481 hasAuthorship W4285386481A5017763740 @default.
- W4285386481 hasAuthorship W4285386481A5026043177 @default.
- W4285386481 hasAuthorship W4285386481A5041432535 @default.
- W4285386481 hasAuthorship W4285386481A5073568638 @default.
- W4285386481 hasAuthorship W4285386481A5077420983 @default.
- W4285386481 hasAuthorship W4285386481A5088465003 @default.
- W4285386481 hasBestOaLocation W42853864811 @default.
- W4285386481 hasConcept C126322002 @default.
- W4285386481 hasConcept C134018914 @default.
- W4285386481 hasConcept C169760540 @default.
- W4285386481 hasConcept C185592680 @default.
- W4285386481 hasConcept C190283241 @default.
- W4285386481 hasConcept C203522944 @default.
- W4285386481 hasConcept C2776848411 @default.
- W4285386481 hasConcept C2777093970 @default.
- W4285386481 hasConcept C2778004101 @default.
- W4285386481 hasConcept C2778231335 @default.
- W4285386481 hasConcept C2779054382 @default.
- W4285386481 hasConcept C2779113765 @default.
- W4285386481 hasConcept C2780827179 @default.
- W4285386481 hasConcept C2781040256 @default.
- W4285386481 hasConcept C54497739 @default.
- W4285386481 hasConcept C55493867 @default.
- W4285386481 hasConcept C71924100 @default.
- W4285386481 hasConcept C86803240 @default.
- W4285386481 hasConcept C95444343 @default.
- W4285386481 hasConceptScore W4285386481C126322002 @default.
- W4285386481 hasConceptScore W4285386481C134018914 @default.
- W4285386481 hasConceptScore W4285386481C169760540 @default.
- W4285386481 hasConceptScore W4285386481C185592680 @default.
- W4285386481 hasConceptScore W4285386481C190283241 @default.
- W4285386481 hasConceptScore W4285386481C203522944 @default.
- W4285386481 hasConceptScore W4285386481C2776848411 @default.
- W4285386481 hasConceptScore W4285386481C2777093970 @default.
- W4285386481 hasConceptScore W4285386481C2778004101 @default.
- W4285386481 hasConceptScore W4285386481C2778231335 @default.