Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285387020> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4285387020 abstract "Abstract Thymic epithelial cells (TEC) play an indispensable role in the development and selection of immunocompetent, yet self-tolerant T cells. To provide further insights into TEC functional and developmental diversity, we utilized multiome analysis, which revealed a detailed atlas of the TEC compartment based on their transcriptional states and chromatin landscapes. The analysis also highlighted numerous unconventional TEC subsets, which shared striking similarities with functionally well-defined parenchymal populations, including endocrine cells, microfold cells or myocytes. Moreover, our fate mapping experiments revealed that most of these rare TEC “parenchymal analogues” differentiated from Csnb+ MHCIIhi mTEC precursors, with varying impacts of Aire on their development. By further focusing on the endocrine- and the microfold-TEC populations, we found that both subsets play different and non-redundant functional roles and require different transcription factors for their terminal differentiation. Specifically, while the endocrine-TEC required Insm1 for their development, and were critical for induction of self-tolerance to various endocrine tissues, the microfold-TEC required Spib for their development, and were essential for the generation of thymic IgA+ plasma cells. Collectively, our study reveals that MHCIIhi mTEC have the potential to differentiate into various types of molecularly functionally defined cells, which not only contribute to the induction of central tolerance, but also regulate homeostasis of other thymus-resident populations." @default.
- W4285387020 created "2022-07-14" @default.
- W4285387020 creator A5004600202 @default.
- W4285387020 creator A5005174685 @default.
- W4285387020 creator A5009187927 @default.
- W4285387020 creator A5027448694 @default.
- W4285387020 creator A5048774677 @default.
- W4285387020 creator A5056540075 @default.
- W4285387020 creator A5060933990 @default.
- W4285387020 creator A5061945872 @default.
- W4285387020 creator A5065413991 @default.
- W4285387020 creator A5068111419 @default.
- W4285387020 creator A5069917573 @default.
- W4285387020 creator A5071408124 @default.
- W4285387020 creator A5073932776 @default.
- W4285387020 creator A5075529754 @default.
- W4285387020 creator A5076062244 @default.
- W4285387020 creator A5086447474 @default.
- W4285387020 creator A5087245701 @default.
- W4285387020 creator A5088900598 @default.
- W4285387020 date "2022-07-14" @default.
- W4285387020 modified "2023-10-14" @default.
- W4285387020 title "Thymic microfold and endocrine cells regulate thymus homeostasis and self-tolerance" @default.
- W4285387020 doi "https://doi.org/10.21203/rs.3.rs-1837610/v1" @default.
- W4285387020 hasPublicationYear "2022" @default.
- W4285387020 type Work @default.
- W4285387020 citedByCount "0" @default.
- W4285387020 crossrefType "posted-content" @default.
- W4285387020 hasAuthorship W4285387020A5004600202 @default.
- W4285387020 hasAuthorship W4285387020A5005174685 @default.
- W4285387020 hasAuthorship W4285387020A5009187927 @default.
- W4285387020 hasAuthorship W4285387020A5027448694 @default.
- W4285387020 hasAuthorship W4285387020A5048774677 @default.
- W4285387020 hasAuthorship W4285387020A5056540075 @default.
- W4285387020 hasAuthorship W4285387020A5060933990 @default.
- W4285387020 hasAuthorship W4285387020A5061945872 @default.
- W4285387020 hasAuthorship W4285387020A5065413991 @default.
- W4285387020 hasAuthorship W4285387020A5068111419 @default.
- W4285387020 hasAuthorship W4285387020A5069917573 @default.
- W4285387020 hasAuthorship W4285387020A5071408124 @default.
- W4285387020 hasAuthorship W4285387020A5073932776 @default.
- W4285387020 hasAuthorship W4285387020A5075529754 @default.
- W4285387020 hasAuthorship W4285387020A5076062244 @default.
- W4285387020 hasAuthorship W4285387020A5086447474 @default.
- W4285387020 hasAuthorship W4285387020A5087245701 @default.
- W4285387020 hasAuthorship W4285387020A5088900598 @default.
- W4285387020 hasBestOaLocation W42853870201 @default.
- W4285387020 hasConcept C103395026 @default.
- W4285387020 hasConcept C104317684 @default.
- W4285387020 hasConcept C116403925 @default.
- W4285387020 hasConcept C121332964 @default.
- W4285387020 hasConcept C1276947 @default.
- W4285387020 hasConcept C134018914 @default.
- W4285387020 hasConcept C176379880 @default.
- W4285387020 hasConcept C46699223 @default.
- W4285387020 hasConcept C54355233 @default.
- W4285387020 hasConcept C63645605 @default.
- W4285387020 hasConcept C71315377 @default.
- W4285387020 hasConcept C83640560 @default.
- W4285387020 hasConcept C86339819 @default.
- W4285387020 hasConcept C86803240 @default.
- W4285387020 hasConcept C95444343 @default.
- W4285387020 hasConceptScore W4285387020C103395026 @default.
- W4285387020 hasConceptScore W4285387020C104317684 @default.
- W4285387020 hasConceptScore W4285387020C116403925 @default.
- W4285387020 hasConceptScore W4285387020C121332964 @default.
- W4285387020 hasConceptScore W4285387020C1276947 @default.
- W4285387020 hasConceptScore W4285387020C134018914 @default.
- W4285387020 hasConceptScore W4285387020C176379880 @default.
- W4285387020 hasConceptScore W4285387020C46699223 @default.
- W4285387020 hasConceptScore W4285387020C54355233 @default.
- W4285387020 hasConceptScore W4285387020C63645605 @default.
- W4285387020 hasConceptScore W4285387020C71315377 @default.
- W4285387020 hasConceptScore W4285387020C83640560 @default.
- W4285387020 hasConceptScore W4285387020C86339819 @default.
- W4285387020 hasConceptScore W4285387020C86803240 @default.
- W4285387020 hasConceptScore W4285387020C95444343 @default.
- W4285387020 hasLocation W42853870201 @default.
- W4285387020 hasOpenAccess W4285387020 @default.
- W4285387020 hasPrimaryLocation W42853870201 @default.
- W4285387020 hasRelatedWork W1488156534 @default.
- W4285387020 hasRelatedWork W1555205165 @default.
- W4285387020 hasRelatedWork W1596845428 @default.
- W4285387020 hasRelatedWork W2005856196 @default.
- W4285387020 hasRelatedWork W2155440983 @default.
- W4285387020 hasRelatedWork W2170175976 @default.
- W4285387020 hasRelatedWork W2437980922 @default.
- W4285387020 hasRelatedWork W2609369331 @default.
- W4285387020 hasRelatedWork W3170669240 @default.
- W4285387020 hasRelatedWork W4376226760 @default.
- W4285387020 isParatext "false" @default.
- W4285387020 isRetracted "false" @default.
- W4285387020 workType "article" @default.