Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285387337> ?p ?o ?g. }
- W4285387337 abstract "Sterol regulatory element binding protein-1 (SREBP-1), a transcription factor with a basic helix-loop-helix leucine zipper, has two isoforms, SREBP-1a and SREBP-1c, derived from the same gene for regulating the genes of lipogenesis, including acetyl-CoA carboxylase, fatty acid synthase, and stearoyl-CoA desaturase. Importantly, SREBP-1 participates in metabolic reprogramming of various cancers and has been a biomarker for the prognosis or drug efficacy for the patients with cancer. In this review, we first introduced the structure, activation, and key upstream signaling pathway of SREBP-1. Then, the potential targets and molecular mechanisms of SREBP-1-regulated lipogenesis in various types of cancer, such as colorectal, prostate, breast, and hepatocellular cancer, were summarized. We also discussed potential therapies targeting the SREBP-1-regulated pathway by small molecules, natural products, or the extracts of herbs against tumor progression. This review could provide new insights in understanding advanced findings about SREBP-1-mediated lipogenesis in cancer and its potential as a target for cancer therapeutics." @default.
- W4285387337 created "2022-07-14" @default.
- W4285387337 creator A5004693417 @default.
- W4285387337 creator A5026605612 @default.
- W4285387337 creator A5089190296 @default.
- W4285387337 date "2022-07-14" @default.
- W4285387337 modified "2023-09-30" @default.
- W4285387337 title "Targeting SREBP-1-Mediated Lipogenesis as Potential Strategies for Cancer" @default.
- W4285387337 cites W1502626307 @default.
- W4285387337 cites W1587936539 @default.
- W4285387337 cites W1713021188 @default.
- W4285387337 cites W1815884866 @default.
- W4285387337 cites W1875102167 @default.
- W4285387337 cites W1900105756 @default.
- W4285387337 cites W1963502214 @default.
- W4285387337 cites W1969875375 @default.
- W4285387337 cites W1972527774 @default.
- W4285387337 cites W1974747471 @default.
- W4285387337 cites W1986605833 @default.
- W4285387337 cites W1986865930 @default.
- W4285387337 cites W1987231965 @default.
- W4285387337 cites W1988476855 @default.
- W4285387337 cites W1989115563 @default.
- W4285387337 cites W2004920315 @default.
- W4285387337 cites W2005563364 @default.
- W4285387337 cites W2005975551 @default.
- W4285387337 cites W2008887768 @default.
- W4285387337 cites W2009616432 @default.
- W4285387337 cites W2013586976 @default.
- W4285387337 cites W2016177837 @default.
- W4285387337 cites W2017947609 @default.
- W4285387337 cites W2021181403 @default.
- W4285387337 cites W2021632088 @default.
- W4285387337 cites W2023719883 @default.
- W4285387337 cites W2035528560 @default.
- W4285387337 cites W2038126428 @default.
- W4285387337 cites W2039999119 @default.
- W4285387337 cites W2040641918 @default.
- W4285387337 cites W2040962503 @default.
- W4285387337 cites W2045868505 @default.
- W4285387337 cites W2051823539 @default.
- W4285387337 cites W2055832574 @default.
- W4285387337 cites W2060783095 @default.
- W4285387337 cites W2070895117 @default.
- W4285387337 cites W2073044222 @default.
- W4285387337 cites W2086453930 @default.
- W4285387337 cites W2086634152 @default.
- W4285387337 cites W2088522484 @default.
- W4285387337 cites W2099711117 @default.
- W4285387337 cites W2104450983 @default.
- W4285387337 cites W2104541017 @default.
- W4285387337 cites W2113334939 @default.
- W4285387337 cites W2115420718 @default.
- W4285387337 cites W2121854747 @default.
- W4285387337 cites W2123595894 @default.
- W4285387337 cites W2124615340 @default.
- W4285387337 cites W2129185045 @default.
- W4285387337 cites W2133225899 @default.
- W4285387337 cites W2135536111 @default.
- W4285387337 cites W2140226600 @default.
- W4285387337 cites W2141862613 @default.
- W4285387337 cites W2144310607 @default.
- W4285387337 cites W2146544786 @default.
- W4285387337 cites W2150555063 @default.
- W4285387337 cites W2155421014 @default.
- W4285387337 cites W2158645874 @default.
- W4285387337 cites W2162187216 @default.
- W4285387337 cites W2168724512 @default.
- W4285387337 cites W2171640413 @default.
- W4285387337 cites W2171820139 @default.
- W4285387337 cites W2282380036 @default.
- W4285387337 cites W2296095373 @default.
- W4285387337 cites W2412871407 @default.
- W4285387337 cites W2417662509 @default.
- W4285387337 cites W2466814596 @default.
- W4285387337 cites W2467842752 @default.
- W4285387337 cites W2498171608 @default.
- W4285387337 cites W2498539528 @default.
- W4285387337 cites W2560441966 @default.
- W4285387337 cites W2562462269 @default.
- W4285387337 cites W2586594911 @default.
- W4285387337 cites W2601507977 @default.
- W4285387337 cites W2606800071 @default.
- W4285387337 cites W2609470048 @default.
- W4285387337 cites W2611024875 @default.
- W4285387337 cites W2752390584 @default.
- W4285387337 cites W2765688680 @default.
- W4285387337 cites W2769873870 @default.
- W4285387337 cites W2776957905 @default.
- W4285387337 cites W2778126883 @default.
- W4285387337 cites W2788314606 @default.
- W4285387337 cites W2792873661 @default.
- W4285387337 cites W2803341036 @default.
- W4285387337 cites W2808863372 @default.
- W4285387337 cites W2811011737 @default.
- W4285387337 cites W2815290681 @default.
- W4285387337 cites W2884545651 @default.
- W4285387337 cites W2888405273 @default.
- W4285387337 cites W2890207868 @default.
- W4285387337 cites W2890298940 @default.