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- W4285387757 abstract "Chronic urticaria (CU) appears with daily or intermittent/recurrent wheals with/without angioedema for more than six weeks. When no specific eliciting factors are found, chronic urticaria is defined as spontaneous (CSU). Up to 50% of patients with CSU do not respond to therapy, leading to a prolonged disease course and the need for expensive therapies, impacting the quality of life (QoL) and healthcare resources.Diagnosis of CSU is made when other potential causes of chronic urticaria are excluded. CSU therapy aims to achieve complete control of symptoms and normalization of QoL. Current treatment options for urticaria aim to target mast cell mediators such as histamine, or activators, such as autoantibodies. Guidelines recommend starting with second generation antihistamines (sgAHs) and adding omalizumab therapy if symptoms are not controlled. This review aims to provide a practical guide for CSU in the pediatric population.Treatment options for pediatric CSU are primarily based on adult data that have been extrapolated for children. Current guidelines should be reevaluated based on pediatric data, new biological treatments, and the COVID-19 pandemic. Future research is needed to investigate strategies to personalize current treatments and identify potential predictive biomarkers." @default.
- W4285387757 created "2022-07-14" @default.
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- W4285387757 date "2022-07-19" @default.
- W4285387757 modified "2023-10-18" @default.
- W4285387757 title "Pediatric chronic spontaneous urticaria: a brief clinician’s guide" @default.
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- W4285387757 doi "https://doi.org/10.1080/1744666x.2022.2101999" @default.
- W4285387757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35833360" @default.
- W4285387757 hasPublicationYear "2022" @default.
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