Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285387816> ?p ?o ?g. }
- W4285387816 endingPage "e0269872" @default.
- W4285387816 startingPage "e0269872" @default.
- W4285387816 abstract "Short-chain fatty acids contribute to normal bowel function and prevent bacterial infections. In particular, butyrate is a promising candidate that plays an important role in regulating the functional integrity of the gastrointestinal tract by stimulating mucin secretion. We investigated whether butyrate treatment modulates mucin secretion and bacterial adherence in LoVo cells. In addition, the possible signaling pathways were also examined in connection with the upregulation of mucin secretion. The results showed that butyrate induced mucin secretion in LoVo cells, resulting in the inhibition of Escherichia coli adhesion by increasing the adherence of Lactobacillus acidophilus and Bifidobacterium longum. The gene expression analysis suggests that mitogen-activated protein kinase (MAPK) signaling pathways including Cdc42-PAK pathway appears to be involved in stimulating mucin secretion. More importantly, butyrate induced the increased actin expression and polymerization in LoVo cells, which could be attributable to the Cdc42-PAK signaling pathway, implicated in actin cytoskeleton and mucin secretion. Our results provide a molecular basis in modulating bacterial adherence and the MAPK signaling pathway for the improved homeostasis of colonic epithelial cells." @default.
- W4285387816 created "2022-07-14" @default.
- W4285387816 creator A5033360108 @default.
- W4285387816 creator A5048252612 @default.
- W4285387816 creator A5070832144 @default.
- W4285387816 creator A5077373938 @default.
- W4285387816 date "2022-07-14" @default.
- W4285387816 modified "2023-09-26" @default.
- W4285387816 title "Butyrate modulates mucin secretion and bacterial adherence in LoVo cells via MAPK signaling" @default.
- W4285387816 cites W1978220578 @default.
- W4285387816 cites W1984061675 @default.
- W4285387816 cites W1993067940 @default.
- W4285387816 cites W1996605785 @default.
- W4285387816 cites W1996933969 @default.
- W4285387816 cites W2023149318 @default.
- W4285387816 cites W2053266223 @default.
- W4285387816 cites W2057199361 @default.
- W4285387816 cites W2060741641 @default.
- W4285387816 cites W2069336691 @default.
- W4285387816 cites W2076386438 @default.
- W4285387816 cites W2082732215 @default.
- W4285387816 cites W2095763151 @default.
- W4285387816 cites W2114277486 @default.
- W4285387816 cites W2144963709 @default.
- W4285387816 cites W2150173080 @default.
- W4285387816 cites W2155628411 @default.
- W4285387816 cites W2236332835 @default.
- W4285387816 cites W2306161944 @default.
- W4285387816 cites W2592350827 @default.
- W4285387816 cites W2732493362 @default.
- W4285387816 cites W2751799791 @default.
- W4285387816 cites W2755336277 @default.
- W4285387816 cites W2884701131 @default.
- W4285387816 cites W2924578805 @default.
- W4285387816 cites W2954311903 @default.
- W4285387816 cites W2996563996 @default.
- W4285387816 cites W3013471276 @default.
- W4285387816 cites W3013726226 @default.
- W4285387816 cites W3024676649 @default.
- W4285387816 doi "https://doi.org/10.1371/journal.pone.0269872" @default.
- W4285387816 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35834581" @default.
- W4285387816 hasPublicationYear "2022" @default.
- W4285387816 type Work @default.
- W4285387816 citedByCount "3" @default.
- W4285387816 countsByYear W42853878162022 @default.
- W4285387816 countsByYear W42853878162023 @default.
- W4285387816 crossrefType "journal-article" @default.
- W4285387816 hasAuthorship W4285387816A5033360108 @default.
- W4285387816 hasAuthorship W4285387816A5048252612 @default.
- W4285387816 hasAuthorship W4285387816A5070832144 @default.
- W4285387816 hasAuthorship W4285387816A5077373938 @default.
- W4285387816 hasBestOaLocation W42853878161 @default.
- W4285387816 hasConcept C100544194 @default.
- W4285387816 hasConcept C142669718 @default.
- W4285387816 hasConcept C1491633281 @default.
- W4285387816 hasConcept C179264091 @default.
- W4285387816 hasConcept C185592680 @default.
- W4285387816 hasConcept C2776979534 @default.
- W4285387816 hasConcept C2780040266 @default.
- W4285387816 hasConcept C2993400109 @default.
- W4285387816 hasConcept C49039625 @default.
- W4285387816 hasConcept C55493867 @default.
- W4285387816 hasConcept C57074206 @default.
- W4285387816 hasConcept C62478195 @default.
- W4285387816 hasConcept C86803240 @default.
- W4285387816 hasConcept C95444343 @default.
- W4285387816 hasConceptScore W4285387816C100544194 @default.
- W4285387816 hasConceptScore W4285387816C142669718 @default.
- W4285387816 hasConceptScore W4285387816C1491633281 @default.
- W4285387816 hasConceptScore W4285387816C179264091 @default.
- W4285387816 hasConceptScore W4285387816C185592680 @default.
- W4285387816 hasConceptScore W4285387816C2776979534 @default.
- W4285387816 hasConceptScore W4285387816C2780040266 @default.
- W4285387816 hasConceptScore W4285387816C2993400109 @default.
- W4285387816 hasConceptScore W4285387816C49039625 @default.
- W4285387816 hasConceptScore W4285387816C55493867 @default.
- W4285387816 hasConceptScore W4285387816C57074206 @default.
- W4285387816 hasConceptScore W4285387816C62478195 @default.
- W4285387816 hasConceptScore W4285387816C86803240 @default.
- W4285387816 hasConceptScore W4285387816C95444343 @default.
- W4285387816 hasIssue "7" @default.
- W4285387816 hasLocation W42853878161 @default.
- W4285387816 hasLocation W42853878162 @default.
- W4285387816 hasLocation W42853878163 @default.
- W4285387816 hasOpenAccess W4285387816 @default.
- W4285387816 hasPrimaryLocation W42853878161 @default.
- W4285387816 hasRelatedWork W1979445446 @default.
- W4285387816 hasRelatedWork W2004726042 @default.
- W4285387816 hasRelatedWork W2051751591 @default.
- W4285387816 hasRelatedWork W2077554422 @default.
- W4285387816 hasRelatedWork W2102224568 @default.
- W4285387816 hasRelatedWork W2157937554 @default.
- W4285387816 hasRelatedWork W2381340599 @default.
- W4285387816 hasRelatedWork W2462039273 @default.
- W4285387816 hasRelatedWork W4285387816 @default.
- W4285387816 hasRelatedWork W4385758414 @default.
- W4285387816 hasVolume "17" @default.
- W4285387816 isParatext "false" @default.