Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285388095> ?p ?o ?g. }
- W4285388095 abstract "Abstract This study aimed to investigate innovative targets in breast cancer patients by considering the interaction of the lncRNA-miR-mRNA network in response to low-dose aspirin. The candidate miRs were first taken from the GEO and TCGA databases. Then, the candidate network was constructed using the high-throughput sequencing data. The expression levels of candidate targets were finally measured using Real-Time PCR in luminal A breast cancer patients undergoing aspirin (80 mg daily for three months) and non-aspirin groups during chemotherapy after surgery. The expression levels of TGFβ, IL-17, IFNγ, and IL-β proteins were measured using the ELISA technique. 5 lncRNAs, 12 miRs, and 10 genes were obtained in the bioinformatic phase. A significant expression increase of the candidate tumor suppressor lncRNAs, miRs, and genes and a substantial expression decrease of the candidate onco-lncRNAs, oncomiRs, and oncogenes were achieved after the aspirin consumption. Unlike the non-aspirin group, the expression levels of TGFβ, IL-17, IFNγ, and IL-β proteins were significantly decreased following aspirin consumption. The Kaplan–Meier analysis indicated a longer overall survival rate in the patients after aspirin consumption. Our results showed that the lncRNA-miR-mRNA network might be a significant target for aspirin; their expression changes may be a new strategy with potential efficacy for cancer therapy or prevention." @default.
- W4285388095 created "2022-07-14" @default.
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- W4285388095 date "2022-07-14" @default.
- W4285388095 modified "2023-10-18" @default.
- W4285388095 title "Innovative targets of the lncRNA-miR-mRNA network in response to low-dose aspirin in breast cancer patients" @default.
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- W4285388095 doi "https://doi.org/10.1038/s41598-022-16398-7" @default.
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