FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285388289> ?p ?o ?g. }

• W4285388289 abstract "Uric acid (UA) is the final product of purine metabolism in the human body, and impaired purine metabolism can increase the uric acid in serum, finally resulting in hyperuricemia (HUA). Current evidences suggest that urates might have antioxidant properties under certain circumstances, but most evidences suggest that urates promote inflammation. Hyperuricemia leads to the formation of urate crystals, which might be recognized as a red flag by the immune system. Such a response stimulates macrophage activation, leads to the activation of NOD-like receptor protein 3 (NLRP3) inflammasome vesicles, and ultimately the production and liberation of interleukin-1b (IL-1b) and interleukin-18 (IL-18), which can mediate inflammation, apoptosis and necroinflammation and cause an inflammatory cascade response. The kidney is one of the most commonly affected organs in HUA, which promotes the development of chronic kidney disease (CKD) by damaging endothelial cells, activating the renin-angiotensin system (RAS), and promoting inflammatory responses. Pharmacological interventions and lifestyle modifications are the primary means for controlling gout and lowering UA. The febuxostat is safe for CKD patients in the UA lowering therapy. Although dialysis can reduce UA levels, the application of drug is also necessary for dialysis patients. This article reviews the synthesis and metabolism of UA, etiology of HUA, the relationship between HUA and kidney disease, the treatment of gout and gouty nephropathy (GN)." @default.
• W4285388289 created "2022-07-14" @default.
• W4285388289 creator A5011252336 @default.
• W4285388289 creator A5059477687 @default.
• W4285388289 creator A5068437649 @default.
• W4285388289 creator A5089983184 @default.
• W4285388289 date "2022-07-14" @default.
• W4285388289 modified "2023-09-25" @default.
• W4285388289 title "Excess Uric Acid Induces Gouty Nephropathy Through Crystal Formation: A Review of Recent Insights" @default.
• W4285388289 cites W1480244603 @default.
• W4285388289 cites W1599893459 @default.
• W4285388289 cites W1985969855 @default.
• W4285388289 cites W1991700740 @default.
• W4285388289 cites W1994501150 @default.
• W4285388289 cites W2002835167 @default.
• W4285388289 cites W2029668562 @default.
• W4285388289 cites W2048359032 @default.
• W4285388289 cites W2052661775 @default.
• W4285388289 cites W2058739664 @default.
• W4285388289 cites W2093413740 @default.
• W4285388289 cites W2094780098 @default.
• W4285388289 cites W2171576765 @default.
• W4285388289 cites W2171699178 @default.
• W4285388289 cites W2190735152 @default.
• W4285388289 cites W2206815231 @default.
• W4285388289 cites W2273161154 @default.
• W4285388289 cites W2282083919 @default.
• W4285388289 cites W2335302945 @default.
• W4285388289 cites W2524484671 @default.
• W4285388289 cites W2525149912 @default.
• W4285388289 cites W2561830273 @default.
• W4285388289 cites W2576559149 @default.
• W4285388289 cites W2613828117 @default.
• W4285388289 cites W2620501140 @default.
• W4285388289 cites W2649650290 @default.
• W4285388289 cites W2765452810 @default.
• W4285388289 cites W2767002831 @default.
• W4285388289 cites W2791591217 @default.
• W4285388289 cites W2793103574 @default.
• W4285388289 cites W2802411153 @default.
• W4285388289 cites W2890296042 @default.
• W4285388289 cites W2890708240 @default.
• W4285388289 cites W2901749260 @default.
• W4285388289 cites W2953313302 @default.
• W4285388289 cites W2958598996 @default.
• W4285388289 cites W2996250016 @default.
• W4285388289 cites W3023256684 @default.
• W4285388289 cites W3039182049 @default.
• W4285388289 cites W3081616819 @default.
• W4285388289 cites W3083598221 @default.
• W4285388289 cites W3087498606 @default.
• W4285388289 cites W3089803202 @default.
• W4285388289 cites W3104282256 @default.
• W4285388289 cites W3119333620 @default.
• W4285388289 cites W3158108545 @default.
• W4285388289 cites W3185612555 @default.
• W4285388289 cites W3194570688 @default.
• W4285388289 cites W4229537562 @default.
• W4285388289 doi "https://doi.org/10.3389/fendo.2022.911968" @default.
• W4285388289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35909538" @default.
• W4285388289 hasPublicationYear "2022" @default.
• W4285388289 type Work @default.
• W4285388289 citedByCount "11" @default.
• W4285388289 countsByYear W42853882892022 @default.
• W4285388289 countsByYear W42853882892023 @default.
• W4285388289 crossrefType "journal-article" @default.
• W4285388289 hasAuthorship W4285388289A5011252336 @default.
• W4285388289 hasAuthorship W4285388289A5059477687 @default.
• W4285388289 hasAuthorship W4285388289A5068437649 @default.
• W4285388289 hasAuthorship W4285388289A5089983184 @default.
• W4285388289 hasBestOaLocation W42853882891 @default.
• W4285388289 hasConcept C126322002 @default.
• W4285388289 hasConcept C134018914 @default.
• W4285388289 hasConcept C2776914184 @default.
• W4285388289 hasConcept C2777209026 @default.
• W4285388289 hasConcept C2778653478 @default.
• W4285388289 hasConcept C2779721657 @default.
• W4285388289 hasConcept C2779881121 @default.
• W4285388289 hasConcept C2779922275 @default.
• W4285388289 hasConcept C2780091579 @default.
• W4285388289 hasConcept C2780402116 @default.
• W4285388289 hasConcept C2780932893 @default.
• W4285388289 hasConcept C2781184683 @default.
• W4285388289 hasConcept C555293320 @default.
• W4285388289 hasConcept C71924100 @default.
• W4285388289 hasConcept C98274493 @default.
• W4285388289 hasConceptScore W4285388289C126322002 @default.
• W4285388289 hasConceptScore W4285388289C134018914 @default.
• W4285388289 hasConceptScore W4285388289C2776914184 @default.
• W4285388289 hasConceptScore W4285388289C2777209026 @default.
• W4285388289 hasConceptScore W4285388289C2778653478 @default.
• W4285388289 hasConceptScore W4285388289C2779721657 @default.
• W4285388289 hasConceptScore W4285388289C2779881121 @default.
• W4285388289 hasConceptScore W4285388289C2779922275 @default.
• W4285388289 hasConceptScore W4285388289C2780091579 @default.
• W4285388289 hasConceptScore W4285388289C2780402116 @default.
• W4285388289 hasConceptScore W4285388289C2780932893 @default.
• W4285388289 hasConceptScore W4285388289C2781184683 @default.
• W4285388289 hasConceptScore W4285388289C555293320 @default.
• W4285388289 hasConceptScore W4285388289C71924100 @default.

• next