FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285388568> ?p ?o ?g. }

• W4285388568 abstract "Abstract Inflammasomes are cytosolic multiprotein complexes that initiate host defense against bacterial pathogens. The nucleotide‐binding oligomerization domain (NOD)‐like receptor (NLR) family caspase‐associated recruitment domain‐containing protein 4 (NLRC4) inflammasomes plays a critical role in the inflammatory response against intracellular bacterial infection. The NLR family apoptosis inhibitory proteins (NAIPs) detect Flagellin or type III secretion system (T3SS) microbial components to activate NLRC4 inflammasome. However, the underlying mechanism of NLRC4 inflammasome activation is not completely understood. Here, we show that the vitamin D receptor (VDR) is an essential immunological regulator of the NLRC4 inflammasome. Conditional VDR knockout mice (VDR flox/flox lyz2‐Cre) exhibited impaired clearance of pathogens after acute Salmonella Typhimurium infection leading to poor survival. In macrophages, VDR deficiency reduced caspase‐1 activation and IL‐1β secretion upon S. Typhimurium infection. For NAIPs act as upstream sensors for NLRC4 inflammasome assembly, the further study demonstrated that VDR promoted the NAIP–NLRC4 association and triggered NAIP–NLRC4 inflammasome activation, not NLRP3 activation. Moreover, Lys123 residue of VDR is identified as the critical amino acid for VDR‐NLRC4 interaction, and the mutant VDR (K123A) effectively attenuates the NLRC4 inflammasome activation. Together, our findings suggest that VDR is a critical regulator of NAIPs–NLRC4 inflammasome activation, mediating innate immunity against bacterial infection." @default.
• W4285388568 created "2022-07-14" @default.
• W4285388568 creator A5001998141 @default.
• W4285388568 creator A5004615404 @default.
• W4285388568 creator A5024130793 @default.
• W4285388568 creator A5040175361 @default.
• W4285388568 creator A5051726766 @default.
• W4285388568 creator A5067038494 @default.
• W4285388568 creator A5074752067 @default.
• W4285388568 creator A5081814390 @default.
• W4285388568 creator A5087135939 @default.
• W4285388568 creator A5088692779 @default.
• W4285388568 creator A5089691479 @default.
• W4285388568 creator A5090109839 @default.
• W4285388568 date "2022-07-14" @default.
• W4285388568 modified "2023-10-15" @default.
• W4285388568 title "Vitamin D receptor enhances <scp>NLRC4</scp> inflammasome activation by promoting <scp>NAIPs–NLRC4</scp> association" @default.
• W4285388568 cites W1522664335 @default.
• W4285388568 cites W1966584131 @default.
• W4285388568 cites W2027946868 @default.
• W4285388568 cites W2028109472 @default.
• W4285388568 cites W2030997154 @default.
• W4285388568 cites W2033726221 @default.
• W4285388568 cites W2034230597 @default.
• W4285388568 cites W2038621270 @default.
• W4285388568 cites W2045953344 @default.
• W4285388568 cites W2052874989 @default.
• W4285388568 cites W2134770376 @default.
• W4285388568 cites W2168120687 @default.
• W4285388568 cites W2346294312 @default.
• W4285388568 cites W2476516954 @default.
• W4285388568 cites W2748076679 @default.
• W4285388568 cites W2778837083 @default.
• W4285388568 cites W2796926129 @default.
• W4285388568 cites W2971833001 @default.
• W4285388568 cites W2993312935 @default.
• W4285388568 cites W3033880725 @default.
• W4285388568 cites W3093021068 @default.
• W4285388568 cites W3112472197 @default.
• W4285388568 cites W3124111517 @default.
• W4285388568 cites W3186825127 @default.
• W4285388568 cites W4226068796 @default.
• W4285388568 cites W4285388568 @default.
• W4285388568 doi "https://doi.org/10.15252/embr.202254611" @default.
• W4285388568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35833522" @default.
• W4285388568 hasPublicationYear "2022" @default.
• W4285388568 type Work @default.
• W4285388568 citedByCount "2" @default.
• W4285388568 countsByYear W42853885682022 @default.
• W4285388568 countsByYear W42853885682023 @default.
• W4285388568 crossrefType "journal-article" @default.
• W4285388568 hasAuthorship W4285388568A5001998141 @default.
• W4285388568 hasAuthorship W4285388568A5004615404 @default.
• W4285388568 hasAuthorship W4285388568A5024130793 @default.
• W4285388568 hasAuthorship W4285388568A5040175361 @default.
• W4285388568 hasAuthorship W4285388568A5051726766 @default.
• W4285388568 hasAuthorship W4285388568A5067038494 @default.
• W4285388568 hasAuthorship W4285388568A5074752067 @default.
• W4285388568 hasAuthorship W4285388568A5081814390 @default.
• W4285388568 hasAuthorship W4285388568A5087135939 @default.
• W4285388568 hasAuthorship W4285388568A5088692779 @default.
• W4285388568 hasAuthorship W4285388568A5089691479 @default.
• W4285388568 hasAuthorship W4285388568A5090109839 @default.
• W4285388568 hasBestOaLocation W42853885682 @default.
• W4285388568 hasConcept C139964883 @default.
• W4285388568 hasConcept C170493617 @default.
• W4285388568 hasConcept C179639408 @default.
• W4285388568 hasConcept C187831198 @default.
• W4285388568 hasConcept C2777209026 @default.
• W4285388568 hasConcept C55493867 @default.
• W4285388568 hasConcept C56432331 @default.
• W4285388568 hasConcept C86803240 @default.
• W4285388568 hasConcept C95444343 @default.
• W4285388568 hasConceptScore W4285388568C139964883 @default.
• W4285388568 hasConceptScore W4285388568C170493617 @default.
• W4285388568 hasConceptScore W4285388568C179639408 @default.
• W4285388568 hasConceptScore W4285388568C187831198 @default.
• W4285388568 hasConceptScore W4285388568C2777209026 @default.
• W4285388568 hasConceptScore W4285388568C55493867 @default.
• W4285388568 hasConceptScore W4285388568C56432331 @default.
• W4285388568 hasConceptScore W4285388568C86803240 @default.
• W4285388568 hasConceptScore W4285388568C95444343 @default.
• W4285388568 hasFunder F4320321001 @default.
• W4285388568 hasIssue "9" @default.
• W4285388568 hasLocation W42853885681 @default.
• W4285388568 hasLocation W42853885682 @default.
• W4285388568 hasLocation W42853885683 @default.
• W4285388568 hasOpenAccess W4285388568 @default.
• W4285388568 hasPrimaryLocation W42853885681 @default.
• W4285388568 hasRelatedWork W1507535592 @default.
• W4285388568 hasRelatedWork W2089003246 @default.
• W4285388568 hasRelatedWork W2585898138 @default.
• W4285388568 hasRelatedWork W2758437386 @default.
• W4285388568 hasRelatedWork W2770467880 @default.
• W4285388568 hasRelatedWork W2810574398 @default.
• W4285388568 hasRelatedWork W3094576014 @default.
• W4285388568 hasRelatedWork W4214660895 @default.
• W4285388568 hasRelatedWork W4366550139 @default.
• W4285388568 hasRelatedWork W4385798234 @default.
• W4285388568 hasVolume "23" @default.

• next