Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285388580> ?p ?o ?g. }
- W4285388580 endingPage "2539" @default.
- W4285388580 startingPage "2529" @default.
- W4285388580 abstract "Abstract Fluopimomide is an innovative pesticide, widely used for agricultural pest management; however, little is known about its effect on non‐target organisms. This study was designed to assess the potential risk of fluopimomide and the molecular mechanisms using Caenorhabditis elegans , a common model animal. The oxidative stress‐related indicators were analyzed in C. elegans after exposure to fluopimomide for 24 h at three sublethal doses (0.2, 1.0, and 5.0 mg/L). The results demonstrated that sublethal exposure to fluopimomide adversely affected the nematodes growth, locomotive behaviors, reproduction, and lifespan, accompanying with enhanced of reactive oxygen species (ROS) generation, lipid and lipofuscin accumulation, and malondialdehyde content. In addition, exposure to fluopimomide significantly inhibited antioxidant systems including superoxide dismutase, catalase, glutathione S‐transferase, and glutathione in the nematodes. Moreover, the expression of oxidative stress‐related genes of sod‐3 , hsp‐16.1 , gst‐4 , ctl‐2 , daf‐16 , and daf‐2 were significantly down‐regulated, while the expression of skn‐1 was significantly up‐regulated. Further evidence revealed that daf‐16 and skn‐1 mutant strains of C. elegans significantly decreased ROS production upon fluopimomide exposure compared with the wild‐type nematodes. Overall, our findings indicated that exposure to fluopimomide at sublethal doses caused oxidative damage, mainly associated with insulin/IGF‐1‐like signaling pathway in C. elegans . This is the first report of potential toxic effects of fluopimomide even at low concentrations, providing a new insight into the mechanisms of toxicity to C. elegans by fluopimomide." @default.
- W4285388580 created "2022-07-14" @default.
- W4285388580 creator A5007951489 @default.
- W4285388580 creator A5014898916 @default.
- W4285388580 creator A5017681049 @default.
- W4285388580 creator A5028948842 @default.
- W4285388580 creator A5032005657 @default.
- W4285388580 creator A5038438329 @default.
- W4285388580 creator A5065601741 @default.
- W4285388580 creator A5077129573 @default.
- W4285388580 date "2022-07-14" @default.
- W4285388580 modified "2023-10-16" @default.
- W4285388580 title "Exposure to fluopimomide at sublethal doses causes oxidative stress in <i>Caenorhabditis elegans</i> regulated by insulin/ <scp>insulin‐like growth factor 1</scp> ‐like signaling pathway" @default.
- W4285388580 cites W1013361806 @default.
- W4285388580 cites W1156765303 @default.
- W4285388580 cites W1809054409 @default.
- W4285388580 cites W1944127002 @default.
- W4285388580 cites W2004112725 @default.
- W4285388580 cites W2027435978 @default.
- W4285388580 cites W2049636331 @default.
- W4285388580 cites W2063098376 @default.
- W4285388580 cites W2071019350 @default.
- W4285388580 cites W2072069758 @default.
- W4285388580 cites W2076153333 @default.
- W4285388580 cites W2077396037 @default.
- W4285388580 cites W2097080469 @default.
- W4285388580 cites W2098567793 @default.
- W4285388580 cites W2099752867 @default.
- W4285388580 cites W2101861123 @default.
- W4285388580 cites W2107277218 @default.
- W4285388580 cites W2111223240 @default.
- W4285388580 cites W2166673444 @default.
- W4285388580 cites W2322250376 @default.
- W4285388580 cites W2330979788 @default.
- W4285388580 cites W2534061888 @default.
- W4285388580 cites W2556343697 @default.
- W4285388580 cites W2561932019 @default.
- W4285388580 cites W2588234422 @default.
- W4285388580 cites W2591210164 @default.
- W4285388580 cites W2593094090 @default.
- W4285388580 cites W2756314208 @default.
- W4285388580 cites W2796118883 @default.
- W4285388580 cites W2805344839 @default.
- W4285388580 cites W2809384550 @default.
- W4285388580 cites W2886176938 @default.
- W4285388580 cites W2888368845 @default.
- W4285388580 cites W2905125869 @default.
- W4285388580 cites W2905933159 @default.
- W4285388580 cites W2911948850 @default.
- W4285388580 cites W2937688094 @default.
- W4285388580 cites W2967726757 @default.
- W4285388580 cites W2992692303 @default.
- W4285388580 cites W2999481712 @default.
- W4285388580 cites W3016501946 @default.
- W4285388580 cites W3028203546 @default.
- W4285388580 cites W3033007598 @default.
- W4285388580 cites W3034824314 @default.
- W4285388580 cites W3045572547 @default.
- W4285388580 cites W3094774816 @default.
- W4285388580 cites W3096604444 @default.
- W4285388580 cites W3100308562 @default.
- W4285388580 cites W3101909170 @default.
- W4285388580 cites W3119658666 @default.
- W4285388580 cites W3122705586 @default.
- W4285388580 cites W3193095237 @default.
- W4285388580 cites W3194940601 @default.
- W4285388580 doi "https://doi.org/10.1002/tox.23616" @default.
- W4285388580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35833599" @default.
- W4285388580 hasPublicationYear "2022" @default.
- W4285388580 type Work @default.
- W4285388580 citedByCount "5" @default.
- W4285388580 countsByYear W42853885802023 @default.
- W4285388580 crossrefType "journal-article" @default.
- W4285388580 hasAuthorship W4285388580A5007951489 @default.
- W4285388580 hasAuthorship W4285388580A5014898916 @default.
- W4285388580 hasAuthorship W4285388580A5017681049 @default.
- W4285388580 hasAuthorship W4285388580A5028948842 @default.
- W4285388580 hasAuthorship W4285388580A5032005657 @default.
- W4285388580 hasAuthorship W4285388580A5038438329 @default.
- W4285388580 hasAuthorship W4285388580A5065601741 @default.
- W4285388580 hasAuthorship W4285388580A5077129573 @default.
- W4285388580 hasConcept C104317684 @default.
- W4285388580 hasConcept C181199279 @default.
- W4285388580 hasConcept C2775838275 @default.
- W4285388580 hasConcept C2776151105 @default.
- W4285388580 hasConcept C2778004101 @default.
- W4285388580 hasConcept C2778401633 @default.
- W4285388580 hasConcept C2778944004 @default.
- W4285388580 hasConcept C2778979269 @default.
- W4285388580 hasConcept C2780829032 @default.
- W4285388580 hasConcept C48349386 @default.
- W4285388580 hasConcept C538909803 @default.
- W4285388580 hasConcept C55493867 @default.
- W4285388580 hasConcept C86803240 @default.
- W4285388580 hasConcept C95444343 @default.
- W4285388580 hasConceptScore W4285388580C104317684 @default.
- W4285388580 hasConceptScore W4285388580C181199279 @default.
- W4285388580 hasConceptScore W4285388580C2775838275 @default.