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- W4285388622 abstract "Abstract The massive accumulation of extrachromosomal ribosomal DNA circles (ERCs) in yeast mother cells has been long cited as the primary driver of replicative ageing. ERCs arise through ribosomal DNA (rDNA) recombination and a wealth of genetic data connects rDNA instability events giving rise to ERCs with shortened lifespan and other ageing pathologies. However, we understand little about the molecular effects of ERC accumulation. Here we studied ageing in the presence and absence of ERCs, and unexpectedly found no evidence of gene expression differences that might indicate stress responses or metabolic feedback caused by ERCs. Neither did we observe any global change in the widespread disruption of gene expression that accompanies yeast ageing, altogether suggesting that ERCs are largely inert. Much of the differential gene expression that accompanies ageing in yeast was actually associated with markers of the Senescence Entry Point (SEP), showing that senescence rather than age underlies these changes. Cells passed the SEP irrespective of ERCs, but we found the SEP to be associated with copy number amplification of a region of chromosome XII between the rDNA and the telomere (ChrXIIr), which arises in aged cells due to rDNA instability but through a different mechanism to ERCs. Therefore, although rDNA copy number increases dramatically with age due to ERC accumulation, our findings implicate ChrXIIr, rather than ERCs, as the primary driver of senescence during budding yeast ageing." @default.
- W4285388622 created "2022-07-14" @default.
- W4285388622 creator A5006460588 @default.
- W4285388622 creator A5015794459 @default.
- W4285388622 creator A5023627324 @default.
- W4285388622 creator A5061028677 @default.
- W4285388622 creator A5065521747 @default.
- W4285388622 date "2022-07-14" @default.
- W4285388622 modified "2023-10-18" @default.
- W4285388622 title "Senescence in yeast is associated with chromosome XII cleavage rather than ribosomal DNA circle accumulation" @default.
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