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- W4285388634 endingPage "3379" @default.
- W4285388634 startingPage "3352" @default.
- W4285388634 abstract "Increasing evidence demonstrates that DNA damage and genome instability play a crucial role in ageing. Mammalian cells have developed a wide range of complex and well‐orchestrated DNA repair pathways to respond to and resolve many different types of DNA lesions that occur from exogenous and endogenous sources. Defects in these repair pathways lead to accelerated or premature ageing syndromes and increase the likelihood of cancer development. Understanding the fundamental mechanisms of DNA repair will help develop novel strategies to treat ageing‐related diseases. Here, we revisit the processes involved in DNA damage repair and how these can contribute to diseases, including ageing and cancer. We also review recent mechanistic insights into DNA repair and discuss how these insights are being used to develop novel therapeutic strategies for treating human disease. We discuss the use of PARP inhibitors in the clinic for the treatment of breast and ovarian cancer and the challenges associated with acquired drug resistance. Finally, we discuss how DNA repair pathway‐targeted therapeutics are moving beyond PARP inhibition in the search for ever more innovative and efficacious cancer therapies." @default.
- W4285388634 created "2022-07-14" @default.
- W4285388634 creator A5016331420 @default.
- W4285388634 creator A5072607124 @default.
- W4285388634 date "2022-07-28" @default.
- W4285388634 modified "2023-09-30" @default.
- W4285388634 title "DNA repair as a shared hallmark in cancer and ageing" @default.
- W4285388634 cites W1516566300 @default.
- W4285388634 cites W1520947267 @default.
- W4285388634 cites W1656708631 @default.
- W4285388634 cites W172772731 @default.
- W4285388634 cites W1965768609 @default.
- W4285388634 cites W1967630574 @default.
- W4285388634 cites W1968516742 @default.
- W4285388634 cites W1969939969 @default.
- W4285388634 cites W1971018769 @default.
- W4285388634 cites W1971602039 @default.
- W4285388634 cites W1973268287 @default.
- W4285388634 cites W197372138 @default.
- W4285388634 cites W1974668065 @default.
- W4285388634 cites W1974755980 @default.
- W4285388634 cites W1976856900 @default.
- W4285388634 cites W1976987484 @default.
- W4285388634 cites W1977362098 @default.
- W4285388634 cites W1981504084 @default.
- W4285388634 cites W1982602899 @default.
- W4285388634 cites W1985308585 @default.
- W4285388634 cites W1986937402 @default.
- W4285388634 cites W1988259427 @default.
- W4285388634 cites W1994394502 @default.
- W4285388634 cites W1997145913 @default.
- W4285388634 cites W1998415606 @default.
- W4285388634 cites W2003848438 @default.
- W4285388634 cites W2004125597 @default.
- W4285388634 cites W2004273407 @default.
- W4285388634 cites W2004314923 @default.
- W4285388634 cites W2004442904 @default.
- W4285388634 cites W2005542290 @default.
- W4285388634 cites W2006806309 @default.
- W4285388634 cites W2008757142 @default.
- W4285388634 cites W2009007206 @default.
- W4285388634 cites W2014177759 @default.
- W4285388634 cites W2014432477 @default.
- W4285388634 cites W2015360671 @default.
- W4285388634 cites W2016033175 @default.
- W4285388634 cites W2018951168 @default.
- W4285388634 cites W2023583823 @default.
- W4285388634 cites W2023620387 @default.
- W4285388634 cites W2028361915 @default.
- W4285388634 cites W2031143675 @default.
- W4285388634 cites W2033004300 @default.
- W4285388634 cites W2040414192 @default.
- W4285388634 cites W2040860750 @default.
- W4285388634 cites W2041897873 @default.
- W4285388634 cites W2041992457 @default.
- W4285388634 cites W2042140414 @default.
- W4285388634 cites W2042518400 @default.
- W4285388634 cites W2042716686 @default.
- W4285388634 cites W2043895957 @default.
- W4285388634 cites W2045466228 @default.
- W4285388634 cites W2046351190 @default.
- W4285388634 cites W2047315860 @default.
- W4285388634 cites W2051279310 @default.
- W4285388634 cites W2052679982 @default.
- W4285388634 cites W2053352181 @default.
- W4285388634 cites W2054866841 @default.
- W4285388634 cites W2055373932 @default.
- W4285388634 cites W2058957446 @default.
- W4285388634 cites W2060247906 @default.
- W4285388634 cites W2061077538 @default.
- W4285388634 cites W2065588235 @default.
- W4285388634 cites W2067951632 @default.
- W4285388634 cites W2068140359 @default.
- W4285388634 cites W2068555261 @default.
- W4285388634 cites W2068973408 @default.
- W4285388634 cites W2069519394 @default.
- W4285388634 cites W2071396509 @default.
- W4285388634 cites W2073569331 @default.
- W4285388634 cites W2074730941 @default.
- W4285388634 cites W2077436902 @default.
- W4285388634 cites W2078518665 @default.
- W4285388634 cites W2078544177 @default.
- W4285388634 cites W2079659589 @default.
- W4285388634 cites W2082431118 @default.
- W4285388634 cites W2084369408 @default.
- W4285388634 cites W2085544302 @default.
- W4285388634 cites W2095156669 @default.
- W4285388634 cites W2096081005 @default.
- W4285388634 cites W2097124161 @default.
- W4285388634 cites W2097948853 @default.
- W4285388634 cites W2102646072 @default.
- W4285388634 cites W2106892764 @default.
- W4285388634 cites W2107816126 @default.
- W4285388634 cites W2108646201 @default.
- W4285388634 cites W2108979392 @default.
- W4285388634 cites W2109560454 @default.
- W4285388634 cites W2112599794 @default.
- W4285388634 cites W2115852450 @default.