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- W4285388638 abstract "Abstract Among various biomaterials, we focused on nanofiber‐based polyglycolic acid (PGA) fabric and examined the dynamics of cells that migrate within the non‐woven fabric after implantation. The efficacy of nano‐PGA as a tissue reinforcement in the process of subcutaneous tissue repair was immunohistochemically investigated. Two types of clinically available PGA non‐woven sheet (nano‐PGA: fiber diameter = 2.0 μm, conventional PGA: fiber diameter = 14.2 μm) were used and subcutaneously implanted in rats. Samples were collected 3 days, and 1, 2, 3, and 4 weeks after the implantation to perform histological and immunohistochemical (CD68, CD163, α‐SMA, Type I collagen, CD34, MCP‐1, IL‐6, TNF‐α, TGF‐β, VEGF, IgG) examinations to assess the expression of molecules related to inflammation or tissue repair. Immunohistochemical analysis in nano‐PGA revealed that the intensity and positive cells (CD68, MCP‐1, IL‐6, TNF‐α) significantly increased which indicated an early inflammatory response. This was followed by phagocytosis of nano‐PGA with foreign body giant cells and CD68+ macrophages. Finally, the number of proliferating cells (CD163, α‐SMA, TGF‐β) and angiogenesis (CD34, VEGF) for tissue repair promoted the formation of collagen fibers (type I collagen). Unlike nano‐PGA, implantation of conventional PGA sheet resulted in a prolonged inflammatory response and was characterized by the presence of discontinuous collagen fibers with many foreign body giant cells, which did not lead to tissue repair. Nano‐PGA sheets demonstrated a better tissue compatibility compared with conventional PGA by inducing early polarization to M2 phenotype macrophages, which triggered subsequent angiogenesis and tissue repair in the subcutaneous tissue." @default.
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- W4285388638 date "2022-07-14" @default.
- W4285388638 modified "2023-10-06" @default.
- W4285388638 title "The significance of nanofiber polyglycolic acid for promoting tissue repair in a rat subcutaneous implantation model" @default.
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- W4285388638 doi "https://doi.org/10.1002/jbm.b.35128" @default.
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