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- W4285388702 endingPage "e0271170" @default.
- W4285388702 startingPage "e0271170" @default.
- W4285388702 abstract "Recent studies showed that genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) is related to attention-deficit hyperactivity disorder (ADHD), bipolar disorder (BD) and schizophrenia (SCZ). However, no consistent conclusion has been determined. This meta-analysis aims to interrogate the relationship between MTHFR gene polymorphisms (677C>T and 1298A>C) and the occurrence of ADHD, BD and SCZ. We retrieved case-control studies that met the inclusion criteria from the PubMed database. Associations between MTHFR polymorphisms (677C>T and 1298A>C) and ADHD, BD and SCZ were measured by means of odds ratios (ORs) using a random effects model and 95% confidence intervals (CIs). Additionally, sensitivity analysis and publication bias were performed. After inclusion criteria were met, a total of five studies with ADHD including 434 cases and 670 controls, 18 studies with BD including 4167 cases and 5901 controls and 44 studies with SCZ including 16,098 cases and 19913 controls were finally included in our meta-analysis. Overall, our meta-analytical results provided evidence that the MTHFR 677C>T was associated with occurrence of BD and SCZ, while the 1298A>C polymorphism was related to ADHD and BD, and additionally the sensitivity analysis indicated these results were stable and reliable. This may provide useful information for relevant studies on the etiology of psychiatric disorders." @default.
- W4285388702 created "2022-07-14" @default.
- W4285388702 creator A5005408475 @default.
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- W4285388702 creator A5062760129 @default.
- W4285388702 creator A5076562586 @default.
- W4285388702 date "2022-07-14" @default.
- W4285388702 modified "2023-09-30" @default.
- W4285388702 title "Association between MTHFR (677C>T and 1298A>C) polymorphisms and psychiatric disorder: A meta-analysis" @default.
- W4285388702 cites W1222268020 @default.
- W4285388702 cites W1499796668 @default.
- W4285388702 cites W1553874788 @default.
- W4285388702 cites W1567127612 @default.
- W4285388702 cites W1963673462 @default.
- W4285388702 cites W1968198781 @default.
- W4285388702 cites W1974945462 @default.
- W4285388702 cites W1976205360 @default.
- W4285388702 cites W1976555550 @default.
- W4285388702 cites W1978560987 @default.
- W4285388702 cites W1982342644 @default.
- W4285388702 cites W1991445431 @default.
- W4285388702 cites W1992947278 @default.
- W4285388702 cites W1994335030 @default.
- W4285388702 cites W1994387786 @default.
- W4285388702 cites W1994989712 @default.
- W4285388702 cites W1996409240 @default.
- W4285388702 cites W1998003446 @default.
- W4285388702 cites W1999137631 @default.
- W4285388702 cites W1999194431 @default.
- W4285388702 cites W1999594908 @default.
- W4285388702 cites W2006224608 @default.
- W4285388702 cites W2010604180 @default.
- W4285388702 cites W2015048034 @default.
- W4285388702 cites W2016093991 @default.
- W4285388702 cites W2016511885 @default.
- W4285388702 cites W2018678855 @default.
- W4285388702 cites W2022948823 @default.
- W4285388702 cites W2025909734 @default.
- W4285388702 cites W2027639190 @default.
- W4285388702 cites W2037110628 @default.
- W4285388702 cites W2037540688 @default.
- W4285388702 cites W2039997546 @default.
- W4285388702 cites W2053958748 @default.
- W4285388702 cites W2054480528 @default.
- W4285388702 cites W2065306158 @default.
- W4285388702 cites W2066739383 @default.
- W4285388702 cites W2066932850 @default.
- W4285388702 cites W2068538032 @default.
- W4285388702 cites W2068616599 @default.
- W4285388702 cites W2069070351 @default.
- W4285388702 cites W2073868696 @default.
- W4285388702 cites W2078019020 @default.
- W4285388702 cites W2082350178 @default.
- W4285388702 cites W2089540887 @default.
- W4285388702 cites W2093507141 @default.
- W4285388702 cites W2096029707 @default.
- W4285388702 cites W2096449513 @default.
- W4285388702 cites W2098320968 @default.
- W4285388702 cites W2098529556 @default.
- W4285388702 cites W2099228155 @default.
- W4285388702 cites W2099270767 @default.
- W4285388702 cites W2099615872 @default.
- W4285388702 cites W2108503721 @default.
- W4285388702 cites W2111347906 @default.
- W4285388702 cites W2116713707 @default.
- W4285388702 cites W2117104588 @default.
- W4285388702 cites W2119903544 @default.
- W4285388702 cites W2122029623 @default.
- W4285388702 cites W2124621777 @default.
- W4285388702 cites W2127521106 @default.
- W4285388702 cites W2134566696 @default.
- W4285388702 cites W2153606794 @default.
- W4285388702 cites W2159061031 @default.
- W4285388702 cites W2161996125 @default.
- W4285388702 cites W2163807154 @default.
- W4285388702 cites W2167859260 @default.
- W4285388702 cites W2170527471 @default.
- W4285388702 cites W2171074660 @default.
- W4285388702 cites W2260159059 @default.
- W4285388702 cites W2278891880 @default.
- W4285388702 cites W2286419146 @default.
- W4285388702 cites W2314289570 @default.
- W4285388702 cites W2397592032 @default.
- W4285388702 cites W2478264217 @default.
- W4285388702 cites W2765227500 @default.
- W4285388702 cites W2770414958 @default.
- W4285388702 cites W2808011097 @default.
- W4285388702 cites W2883351782 @default.
- W4285388702 cites W2900262677 @default.
- W4285388702 cites W2923483102 @default.
- W4285388702 cites W2949712093 @default.
- W4285388702 cites W2952584078 @default.
- W4285388702 cites W2978460587 @default.
- W4285388702 cites W3033293187 @default.
- W4285388702 cites W3087811357 @default.