Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285388725> ?p ?o ?g. }
- W4285388725 abstract "Because of immunotherapy failure in lung adenocarcinoma, we have tried to find new potential biomarkers for differentiating different tumor subtypes and predicting prognosis. We identified two subtypes based on tumor microenvironment-related genes in this study. We used seven methods to analyze the immune cell infiltration between subgroups. Further analysis of tumor mutation load and immune checkpoint expression among different subgroups was performed. The least absolute shrinkage and selection operator Cox regression was applied for further selection. The selected genes were used to construct a prognostic 14-gene signature for LUAD. Next, a survival analysis and time-dependent receiver operating characteristics were performed to verify and evaluate the model. Gene set enrichment analyses and immune analysis in risk groups was also performed. According to the expression of genes related to the tumor microenvironment, lung adenocarcinoma can be divided into cold tumors and hot tumors. The signature we built was able to predict prognosis more accurately than previously known models. The signature-based tumor microenvironment provides further insight into the prediction of lung adenocarcinoma prognosis and may guide individualized treatment." @default.
- W4285388725 created "2022-07-14" @default.
- W4285388725 creator A5006229890 @default.
- W4285388725 creator A5036658104 @default.
- W4285388725 creator A5042117243 @default.
- W4285388725 date "2022-07-14" @default.
- W4285388725 modified "2023-09-26" @default.
- W4285388725 title "Clustering analysis and prognostic signature of lung adenocarcinoma based on the tumor microenvironment" @default.
- W4285388725 cites W1666785645 @default.
- W4285388725 cites W2008062915 @default.
- W4285388725 cites W2023996790 @default.
- W4285388725 cites W2028433016 @default.
- W4285388725 cites W2069592230 @default.
- W4285388725 cites W2073023604 @default.
- W4285388725 cites W2124427232 @default.
- W4285388725 cites W2126512663 @default.
- W4285388725 cites W2129925362 @default.
- W4285388725 cites W2136787567 @default.
- W4285388725 cites W2149199519 @default.
- W4285388725 cites W2159707944 @default.
- W4285388725 cites W2384826382 @default.
- W4285388725 cites W2395048215 @default.
- W4285388725 cites W2533508881 @default.
- W4285388725 cites W2552779786 @default.
- W4285388725 cites W2560367415 @default.
- W4285388725 cites W2601596971 @default.
- W4285388725 cites W2622499649 @default.
- W4285388725 cites W2765224588 @default.
- W4285388725 cites W2788142646 @default.
- W4285388725 cites W2796207838 @default.
- W4285388725 cites W2884784378 @default.
- W4285388725 cites W2889646458 @default.
- W4285388725 cites W2904028121 @default.
- W4285388725 cites W2904370205 @default.
- W4285388725 cites W2907564726 @default.
- W4285388725 cites W2936229903 @default.
- W4285388725 cites W2950733633 @default.
- W4285388725 cites W2952001873 @default.
- W4285388725 cites W2969266674 @default.
- W4285388725 cites W2969802526 @default.
- W4285388725 cites W3006556144 @default.
- W4285388725 cites W3010022505 @default.
- W4285388725 cites W3011027479 @default.
- W4285388725 cites W3087822348 @default.
- W4285388725 cites W3090340087 @default.
- W4285388725 cites W3128131226 @default.
- W4285388725 cites W3164361216 @default.
- W4285388725 cites W3172911572 @default.
- W4285388725 cites W3196333761 @default.
- W4285388725 cites W3196744247 @default.
- W4285388725 cites W3213735273 @default.
- W4285388725 doi "https://doi.org/10.1038/s41598-022-15971-4" @default.
- W4285388725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35835908" @default.
- W4285388725 hasPublicationYear "2022" @default.
- W4285388725 type Work @default.
- W4285388725 citedByCount "0" @default.
- W4285388725 crossrefType "journal-article" @default.
- W4285388725 hasAuthorship W4285388725A5006229890 @default.
- W4285388725 hasAuthorship W4285388725A5036658104 @default.
- W4285388725 hasAuthorship W4285388725A5042117243 @default.
- W4285388725 hasBestOaLocation W42853887251 @default.
- W4285388725 hasConcept C104317684 @default.
- W4285388725 hasConcept C10515644 @default.
- W4285388725 hasConcept C121608353 @default.
- W4285388725 hasConcept C126322002 @default.
- W4285388725 hasConcept C143998085 @default.
- W4285388725 hasConcept C150194340 @default.
- W4285388725 hasConcept C203014093 @default.
- W4285388725 hasConcept C2776107976 @default.
- W4285388725 hasConcept C2776256026 @default.
- W4285388725 hasConcept C2777701055 @default.
- W4285388725 hasConcept C2779733811 @default.
- W4285388725 hasConcept C2781182431 @default.
- W4285388725 hasConcept C502942594 @default.
- W4285388725 hasConcept C50382708 @default.
- W4285388725 hasConcept C54355233 @default.
- W4285388725 hasConcept C70721500 @default.
- W4285388725 hasConcept C71924100 @default.
- W4285388725 hasConcept C86803240 @default.
- W4285388725 hasConcept C8891405 @default.
- W4285388725 hasConceptScore W4285388725C104317684 @default.
- W4285388725 hasConceptScore W4285388725C10515644 @default.
- W4285388725 hasConceptScore W4285388725C121608353 @default.
- W4285388725 hasConceptScore W4285388725C126322002 @default.
- W4285388725 hasConceptScore W4285388725C143998085 @default.
- W4285388725 hasConceptScore W4285388725C150194340 @default.
- W4285388725 hasConceptScore W4285388725C203014093 @default.
- W4285388725 hasConceptScore W4285388725C2776107976 @default.
- W4285388725 hasConceptScore W4285388725C2776256026 @default.
- W4285388725 hasConceptScore W4285388725C2777701055 @default.
- W4285388725 hasConceptScore W4285388725C2779733811 @default.
- W4285388725 hasConceptScore W4285388725C2781182431 @default.
- W4285388725 hasConceptScore W4285388725C502942594 @default.
- W4285388725 hasConceptScore W4285388725C50382708 @default.
- W4285388725 hasConceptScore W4285388725C54355233 @default.
- W4285388725 hasConceptScore W4285388725C70721500 @default.
- W4285388725 hasConceptScore W4285388725C71924100 @default.
- W4285388725 hasConceptScore W4285388725C86803240 @default.
- W4285388725 hasConceptScore W4285388725C8891405 @default.
- W4285388725 hasIssue "1" @default.