FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285388876> ?p ?o ?g. }

• W4285388876 endingPage "4188" @default.
• W4285388876 startingPage "4169" @default.
• W4285388876 abstract "Lusutrombopag is an oral thrombopoietin receptor agonist (TPO-RA). Clinical trials have shown lusutrombopag’s efficacy in reducing need for preoperative platelet transfusion in patients with chronic liver disease (CLD) and severe thrombocytopenia. This analysis assessed efficacy and safety of lusutrombopag in patients with severe thrombocytopenia and CLD undergoing planned invasive procedures. An electronic database search (through 1 December 2020) identified three randomised, placebo-controlled, double-blind clinical trials comparing lusutrombopag with placebo in patients with CLD and platelet count below 50 × 109/L scheduled to undergo a procedure with a perioperative bleeding risk. A random-effects meta-analysis examined treatment effect, with Cochrane Collaboration’s tool assessing risk of bias. The meta-analysis included 343 (lusutrombopag 3 mg, n = 173; placebo, n = 170) patients. More patients met the criteria for treatment response (platelet count at least 50 × 109/L and increase of at least 20 × 109/L from baseline anytime during the study) with lusutrombopag versus placebo (risk ratio [RR] 6.39; 95% confidence interval [CI] 3.69, 11.07; p < 0.0001). The primary efficacy outcome, proportion of patients requiring no platelet transfusion and no rescue therapy for bleeding for at least 7 days post procedure, was achieved by more patients treated with lusutrombopag versus placebo (RR 3.42; 95% CI 1.86, 6.26; p = 0.0001). The risk of any bleeding event was significantly lower with lusutrombopag compared to placebo (RR 0.55; 95% CI 0.32, 0.95; p = 0.03); conversely, thrombosis event rates were similar between lusutrombopag and placebo (RR 0.79; 95% CI 0.19, 3.24; p = 0.74). This meta-analysis showed that treatment of severe thrombocytopenia with lusutrombopag in patients with CLD prior to a planned invasive procedure was efficacious and safe in increasing platelet counts, avoiding the need for platelet transfusions, and reducing risk of bleeding, thereby enhancing the certainty of evidence supporting the efficacy and safety of lusutrombopag." @default.
• W4285388876 created "2022-07-14" @default.
• W4285388876 creator A5015711817 @default.
• W4285388876 creator A5023553051 @default.
• W4285388876 creator A5028132227 @default.
• W4285388876 creator A5052742729 @default.
• W4285388876 creator A5060214913 @default.
• W4285388876 creator A5062274091 @default.
• W4285388876 creator A5073155315 @default.
• W4285388876 creator A5073880705 @default.
• W4285388876 creator A5076739762 @default.
• W4285388876 date "2022-07-14" @default.
• W4285388876 modified "2023-10-15" @default.
• W4285388876 title "Systematic Review with Meta-Analysis: Efficacy and Safety of Lusutrombopag for Severe Thrombocytopenia in Patients with Chronic Liver Disease Undergoing Invasive Procedures" @default.
• W4285388876 cites W1420525479 @default.
• W4285388876 cites W1595237219 @default.
• W4285388876 cites W18503705 @default.
• W4285388876 cites W1966880206 @default.
• W4285388876 cites W1973631133 @default.
• W4285388876 cites W1994051580 @default.
• W4285388876 cites W2013864258 @default.
• W4285388876 cites W2015737784 @default.
• W4285388876 cites W2017796110 @default.
• W4285388876 cites W2086252784 @default.
• W4285388876 cites W2096230132 @default.
• W4285388876 cites W2096334834 @default.
• W4285388876 cites W2103026252 @default.
• W4285388876 cites W2104062274 @default.
• W4285388876 cites W2108532099 @default.
• W4285388876 cites W2119297205 @default.
• W4285388876 cites W2128640268 @default.
• W4285388876 cites W2130601804 @default.
• W4285388876 cites W2131110767 @default.
• W4285388876 cites W2135796724 @default.
• W4285388876 cites W2147982575 @default.
• W4285388876 cites W2158441687 @default.
• W4285388876 cites W2167147321 @default.
• W4285388876 cites W2170521505 @default.
• W4285388876 cites W2278397630 @default.
• W4285388876 cites W2341070770 @default.
• W4285388876 cites W2396586509 @default.
• W4285388876 cites W2564420797 @default.
• W4285388876 cites W2802906787 @default.
• W4285388876 cites W2804718317 @default.
• W4285388876 cites W2808847779 @default.
• W4285388876 cites W2809833128 @default.
• W4285388876 cites W2883884766 @default.
• W4285388876 cites W2886985238 @default.
• W4285388876 cites W2887140939 @default.
• W4285388876 cites W2903290230 @default.
• W4285388876 cites W2911588836 @default.
• W4285388876 cites W2943400272 @default.
• W4285388876 cites W2962870968 @default.
• W4285388876 cites W3009106703 @default.
• W4285388876 cites W3016094609 @default.
• W4285388876 cites W3096894459 @default.
• W4285388876 cites W3103618496 @default.
• W4285388876 cites W3113344411 @default.
• W4285388876 cites W3123287832 @default.
• W4285388876 cites W3126981220 @default.
• W4285388876 cites W3127192261 @default.
• W4285388876 cites W3171968135 @default.
• W4285388876 cites W4211098689 @default.
• W4285388876 doi "https://doi.org/10.1007/s12325-022-02235-w" @default.
• W4285388876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35836089" @default.
• W4285388876 hasPublicationYear "2022" @default.
• W4285388876 type Work @default.
• W4285388876 citedByCount "2" @default.
• W4285388876 countsByYear W42853888762023 @default.
• W4285388876 crossrefType "journal-article" @default.
• W4285388876 hasAuthorship W4285388876A5015711817 @default.
• W4285388876 hasAuthorship W4285388876A5023553051 @default.
• W4285388876 hasAuthorship W4285388876A5028132227 @default.
• W4285388876 hasAuthorship W4285388876A5052742729 @default.
• W4285388876 hasAuthorship W4285388876A5060214913 @default.
• W4285388876 hasAuthorship W4285388876A5062274091 @default.
• W4285388876 hasAuthorship W4285388876A5073155315 @default.
• W4285388876 hasAuthorship W4285388876A5073880705 @default.
• W4285388876 hasAuthorship W4285388876A5076739762 @default.
• W4285388876 hasBestOaLocation W42853888761 @default.
• W4285388876 hasConcept C126322002 @default.
• W4285388876 hasConcept C141071460 @default.
• W4285388876 hasConcept C142724271 @default.
• W4285388876 hasConcept C204787440 @default.
• W4285388876 hasConcept C27081682 @default.
• W4285388876 hasConcept C2776689292 @default.
• W4285388876 hasConcept C2777214474 @default.
• W4285388876 hasConcept C2779102576 @default.
• W4285388876 hasConcept C44249647 @default.
• W4285388876 hasConcept C71924100 @default.
• W4285388876 hasConcept C82789193 @default.
• W4285388876 hasConcept C89560881 @default.
• W4285388876 hasConcept C95190672 @default.
• W4285388876 hasConceptScore W4285388876C126322002 @default.
• W4285388876 hasConceptScore W4285388876C141071460 @default.
• W4285388876 hasConceptScore W4285388876C142724271 @default.
• W4285388876 hasConceptScore W4285388876C204787440 @default.
• W4285388876 hasConceptScore W4285388876C27081682 @default.

• next