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- W4285389075 abstract "In this review, we comprehensively, qualitatively, and critically synthesized several features of APOE-e2, a known APOE protective variant, including its associations with longevity, cognition, and neuroimaging, and neuropathology, all in humans. If e2's protective effects-and their limits-could be elucidated, it could offer therapeutic windows for Alzheimer's disease (AD) prevention or amelioration. Literature examining e2 within the years 1994-2021 were considered for this review. Studies on human subjects were selectively reviewed and were excluded if observation of e2 was not specified. Effects of e2 were compared with e3 and e4, separately and as a combined non-e2 group. Our examination of existing literature indicated that the most robust protective role of e2 is in longevity and AD neuropathologies, but e2's effect on cognition and other AD imaging markers (brain structure, function, and metabolism) were inconsistent, thus inconclusive. Notably, e2 was associated with greater risk of non-AD proteinopathies and a disadvantageous cerebrovascular profile. We identified multiple methodological shortcomings of the literature on brain function and cognition that could have contributed to inconsistent and potentially misleading findings. We make careful interpretations of existing findings and provide directions for research strategies that could effectively examine the independent and unbiased effect of e2 on AD risk." @default.
- W4285389075 created "2022-07-14" @default.
- W4285389075 creator A5030515756 @default.
- W4285389075 creator A5033091196 @default.
- W4285389075 creator A5068879555 @default.
- W4285389075 creator A5072364178 @default.
- W4285389075 date "2022-07-14" @default.
- W4285389075 modified "2023-10-18" @default.
- W4285389075 title "Apolipoprotein E Genotype e2: Neuroprotection and Its Limits" @default.
- W4285389075 cites W1501035907 @default.
- W4285389075 cites W1522448920 @default.
- W4285389075 cites W1526540789 @default.
- W4285389075 cites W1825683130 @default.
- W4285389075 cites W1843712425 @default.
- W4285389075 cites W1956968755 @default.
- W4285389075 cites W1958554455 @default.
- W4285389075 cites W1968725150 @default.
- W4285389075 cites W1972033631 @default.
- W4285389075 cites W1972052307 @default.
- W4285389075 cites W1977511373 @default.
- W4285389075 cites W1981554609 @default.
- W4285389075 cites W1983258394 @default.
- W4285389075 cites W1984737558 @default.
- W4285389075 cites W1985137206 @default.
- W4285389075 cites W1991044584 @default.
- W4285389075 cites W1994787669 @default.
- W4285389075 cites W1999442954 @default.
- W4285389075 cites W1999670317 @default.
- W4285389075 cites W2006534012 @default.
- W4285389075 cites W2007376816 @default.
- W4285389075 cites W2010518142 @default.
- W4285389075 cites W2014342740 @default.
- W4285389075 cites W2014897304 @default.
- W4285389075 cites W2017079501 @default.
- W4285389075 cites W2017654651 @default.
- W4285389075 cites W2018785940 @default.
- W4285389075 cites W2020402140 @default.
- W4285389075 cites W2020720625 @default.
- W4285389075 cites W2021181758 @default.
- W4285389075 cites W2025538133 @default.
- W4285389075 cites W2028262213 @default.
- W4285389075 cites W2029151785 @default.
- W4285389075 cites W2030714315 @default.
- W4285389075 cites W2030933555 @default.
- W4285389075 cites W2032212934 @default.
- W4285389075 cites W2032453195 @default.
- W4285389075 cites W2035057610 @default.
- W4285389075 cites W2035888786 @default.
- W4285389075 cites W2036362108 @default.
- W4285389075 cites W2044692031 @default.
- W4285389075 cites W2046985190 @default.
- W4285389075 cites W2052243021 @default.
- W4285389075 cites W2054007740 @default.
- W4285389075 cites W2056454824 @default.
- W4285389075 cites W2057329207 @default.
- W4285389075 cites W2059381436 @default.
- W4285389075 cites W2064179601 @default.
- W4285389075 cites W2066123530 @default.
- W4285389075 cites W2066673859 @default.
- W4285389075 cites W2067079625 @default.
- W4285389075 cites W2069863984 @default.
- W4285389075 cites W2075467558 @default.
- W4285389075 cites W2076631828 @default.
- W4285389075 cites W2076778216 @default.
- W4285389075 cites W2079090326 @default.
- W4285389075 cites W2088526201 @default.
- W4285389075 cites W2089435027 @default.
- W4285389075 cites W2090271811 @default.
- W4285389075 cites W2091041552 @default.
- W4285389075 cites W2091775763 @default.
- W4285389075 cites W2092189536 @default.
- W4285389075 cites W2092473186 @default.
- W4285389075 cites W2100440179 @default.
- W4285389075 cites W2100948379 @default.
- W4285389075 cites W2101189081 @default.
- W4285389075 cites W2104850453 @default.
- W4285389075 cites W2106392447 @default.
- W4285389075 cites W2110291356 @default.
- W4285389075 cites W2111175305 @default.
- W4285389075 cites W2115182824 @default.
- W4285389075 cites W2116137154 @default.
- W4285389075 cites W2116808034 @default.
- W4285389075 cites W2117437037 @default.
- W4285389075 cites W2126833905 @default.
- W4285389075 cites W2130006532 @default.
- W4285389075 cites W2132998463 @default.
- W4285389075 cites W2135063296 @default.
- W4285389075 cites W2137473937 @default.
- W4285389075 cites W2137792435 @default.
- W4285389075 cites W2139923031 @default.
- W4285389075 cites W2146839662 @default.
- W4285389075 cites W2153350589 @default.
- W4285389075 cites W2154034238 @default.
- W4285389075 cites W2158683061 @default.
- W4285389075 cites W2159285109 @default.
- W4285389075 cites W2161925307 @default.
- W4285389075 cites W2163962821 @default.
- W4285389075 cites W2165293684 @default.
- W4285389075 cites W2167840686 @default.
- W4285389075 cites W2168357345 @default.