Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285389177> ?p ?o ?g. }
- W4285389177 abstract "Precocious puberty mostly stems from endocrine disorders. However, more and more studies show that a high-fat diet (HFD) is closely related to precocious puberty, but its mechanism is unknown. Since gut microbiota is associated with hormone secretion and obesity, it inspires us to detect the mechanism of gut microbiota in triggering precocious puberty. The model of precocious puberty was established by feeding female mice with an HFD from 21 days old. After puberty, the serum hormone levels, gut microbiome sequencing, and metabolomics were collected. DNA was extracted from feces, and the V3–V4 region of the bacterial 16S rRNA gene was amplified, followed by microbial composition analysis. Subsequently, associations between precocious puberty and the microbiota were determined. We found that (1) HFD after weaning caused precocious puberty, increased serum estradiol, leptin, deoxycholic acid (DCA), and gonadotropin-releasing hormone (GnRH) in the hypothalamus; (2) Through correlation analysis, we found that GnRH was positively correlated with Desulfovibrio, Lachnoclostridium, GCA-900066575, Streptococcus, Anaerotruncus , and Bifidobacterium , suggesting that these bacteria may have a role in promoting sexual development. (3) “HFD-microbiota” transplantation promoted the precocious puberty of mice. (4) Estrogen changes the composition and proportion of gut microbiota and promotes precocious puberty. Therefore, the effect of HFD on precocious puberty is regulated by the interaction of gut microbiota and hormones." @default.
- W4285389177 created "2022-07-14" @default.
- W4285389177 creator A5007582637 @default.
- W4285389177 creator A5017353282 @default.
- W4285389177 creator A5038346457 @default.
- W4285389177 creator A5038860267 @default.
- W4285389177 creator A5059153771 @default.
- W4285389177 creator A5071957113 @default.
- W4285389177 date "2022-07-14" @default.
- W4285389177 modified "2023-09-26" @default.
- W4285389177 title "Effects of High-Fat Diet During Childhood on Precocious Puberty and Gut Microbiota in Mice" @default.
- W4285389177 cites W1919048856 @default.
- W4285389177 cites W1964782601 @default.
- W4285389177 cites W1971415551 @default.
- W4285389177 cites W1992041715 @default.
- W4285389177 cites W1999660481 @default.
- W4285389177 cites W2001092096 @default.
- W4285389177 cites W2035797960 @default.
- W4285389177 cites W2052051184 @default.
- W4285389177 cites W2083119809 @default.
- W4285389177 cites W2085847834 @default.
- W4285389177 cites W2088434826 @default.
- W4285389177 cites W2091888593 @default.
- W4285389177 cites W2125568646 @default.
- W4285389177 cites W2137988068 @default.
- W4285389177 cites W2161126547 @default.
- W4285389177 cites W2322909744 @default.
- W4285389177 cites W2587996254 @default.
- W4285389177 cites W2732597986 @default.
- W4285389177 cites W2805440234 @default.
- W4285389177 cites W2896639721 @default.
- W4285389177 cites W2903190154 @default.
- W4285389177 cites W2952437732 @default.
- W4285389177 cites W2963132797 @default.
- W4285389177 cites W2964698358 @default.
- W4285389177 cites W2983596012 @default.
- W4285389177 cites W3003755967 @default.
- W4285389177 cites W3010829439 @default.
- W4285389177 cites W3034001698 @default.
- W4285389177 cites W3089698117 @default.
- W4285389177 cites W3093243853 @default.
- W4285389177 cites W3093353588 @default.
- W4285389177 cites W3106674414 @default.
- W4285389177 cites W3107645065 @default.
- W4285389177 cites W3125185216 @default.
- W4285389177 doi "https://doi.org/10.3389/fmicb.2022.930747" @default.
- W4285389177 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35910597" @default.
- W4285389177 hasPublicationYear "2022" @default.
- W4285389177 type Work @default.
- W4285389177 citedByCount "7" @default.
- W4285389177 countsByYear W42853891772022 @default.
- W4285389177 countsByYear W42853891772023 @default.
- W4285389177 crossrefType "journal-article" @default.
- W4285389177 hasAuthorship W4285389177A5007582637 @default.
- W4285389177 hasAuthorship W4285389177A5017353282 @default.
- W4285389177 hasAuthorship W4285389177A5038346457 @default.
- W4285389177 hasAuthorship W4285389177A5038860267 @default.
- W4285389177 hasAuthorship W4285389177A5059153771 @default.
- W4285389177 hasAuthorship W4285389177A5071957113 @default.
- W4285389177 hasBestOaLocation W42853891771 @default.
- W4285389177 hasConcept C126322002 @default.
- W4285389177 hasConcept C134018914 @default.
- W4285389177 hasConcept C143121216 @default.
- W4285389177 hasConcept C203014093 @default.
- W4285389177 hasConcept C2777164284 @default.
- W4285389177 hasConcept C2778367240 @default.
- W4285389177 hasConcept C2778575703 @default.
- W4285389177 hasConcept C2778894405 @default.
- W4285389177 hasConcept C539455810 @default.
- W4285389177 hasConcept C54355233 @default.
- W4285389177 hasConcept C71315377 @default.
- W4285389177 hasConcept C71924100 @default.
- W4285389177 hasConcept C86803240 @default.
- W4285389177 hasConceptScore W4285389177C126322002 @default.
- W4285389177 hasConceptScore W4285389177C134018914 @default.
- W4285389177 hasConceptScore W4285389177C143121216 @default.
- W4285389177 hasConceptScore W4285389177C203014093 @default.
- W4285389177 hasConceptScore W4285389177C2777164284 @default.
- W4285389177 hasConceptScore W4285389177C2778367240 @default.
- W4285389177 hasConceptScore W4285389177C2778575703 @default.
- W4285389177 hasConceptScore W4285389177C2778894405 @default.
- W4285389177 hasConceptScore W4285389177C539455810 @default.
- W4285389177 hasConceptScore W4285389177C54355233 @default.
- W4285389177 hasConceptScore W4285389177C71315377 @default.
- W4285389177 hasConceptScore W4285389177C71924100 @default.
- W4285389177 hasConceptScore W4285389177C86803240 @default.
- W4285389177 hasLocation W42853891771 @default.
- W4285389177 hasLocation W42853891772 @default.
- W4285389177 hasLocation W42853891773 @default.
- W4285389177 hasOpenAccess W4285389177 @default.
- W4285389177 hasPrimaryLocation W42853891771 @default.
- W4285389177 hasRelatedWork W1963710704 @default.
- W4285389177 hasRelatedWork W1988885444 @default.
- W4285389177 hasRelatedWork W1995647897 @default.
- W4285389177 hasRelatedWork W2013481652 @default.
- W4285389177 hasRelatedWork W2070386770 @default.
- W4285389177 hasRelatedWork W2101821182 @default.
- W4285389177 hasRelatedWork W2109882125 @default.
- W4285389177 hasRelatedWork W2138409845 @default.
- W4285389177 hasRelatedWork W2168803779 @default.