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- W4285389733 endingPage "786" @default.
- W4285389733 startingPage "770" @default.
- W4285389733 abstract "A group of steroidogenic enzymes, hydroxysteroid dehydrogenases are involved in steroid metabolism which is very important in the cell: signaling, growth, reproduction, and energy homeostasis. The enzymes show an inherent function in the interconversion of ketosteroids and hydroxysteroids in a position- and stereospecific manner on the steroid nucleus and side-chains. However, the biocatalysis of steroids reaction is a vital and demanding, yet challenging, task to produce the desired enantiopure products with non-natural substrates or non-natural cofactors, and/or in non-physiological conditions. This has driven the use of protein design strategies to improve their inherent biosynthetic efficiency or activate their silent catalytic ability. In this review, the innate features and catalytic characteristics of enzymes based on sequence-structure-function relationships of steroidogenic enzymes are reviewed. Combining structure information and catalytic mechanisms, progress in protein redesign to stimulate potential function, for example, substrate specificity, cofactor dependence, and catalytic stability are discussed." @default.
- W4285389733 created "2022-07-14" @default.
- W4285389733 creator A5023214008 @default.
- W4285389733 creator A5026865904 @default.
- W4285389733 creator A5034094966 @default.
- W4285389733 creator A5071041799 @default.
- W4285389733 date "2022-07-14" @default.
- W4285389733 modified "2023-10-18" @default.
- W4285389733 title "Structure-based rational design of hydroxysteroid dehydrogenases for improving and diversifying steroid synthesis" @default.
- W4285389733 cites W1557563102 @default.
- W4285389733 cites W1926250975 @default.
- W4285389733 cites W1936850062 @default.
- W4285389733 cites W1966034949 @default.
- W4285389733 cites W1968906639 @default.
- W4285389733 cites W1970184855 @default.
- W4285389733 cites W1972800947 @default.
- W4285389733 cites W1984499966 @default.
- W4285389733 cites W1991639177 @default.
- W4285389733 cites W1994930567 @default.
- W4285389733 cites W1997014699 @default.
- W4285389733 cites W2001817013 @default.
- W4285389733 cites W2007245161 @default.
- W4285389733 cites W2009171847 @default.
- W4285389733 cites W2025014974 @default.
- W4285389733 cites W2036532473 @default.
- W4285389733 cites W2040903454 @default.
- W4285389733 cites W2049602456 @default.
- W4285389733 cites W2050976606 @default.
- W4285389733 cites W2051741107 @default.
- W4285389733 cites W2054799600 @default.
- W4285389733 cites W2056886330 @default.
- W4285389733 cites W2060493427 @default.
- W4285389733 cites W2062949189 @default.
- W4285389733 cites W2068965716 @default.
- W4285389733 cites W2070076389 @default.
- W4285389733 cites W2071273298 @default.
- W4285389733 cites W2073465422 @default.
- W4285389733 cites W2077910607 @default.
- W4285389733 cites W2078086567 @default.
- W4285389733 cites W2087614469 @default.
- W4285389733 cites W2096478114 @default.
- W4285389733 cites W2100965400 @default.
- W4285389733 cites W2103083136 @default.
- W4285389733 cites W2109308298 @default.
- W4285389733 cites W2109886704 @default.
- W4285389733 cites W2113309120 @default.
- W4285389733 cites W2115167726 @default.
- W4285389733 cites W2116124994 @default.
- W4285389733 cites W2123906667 @default.
- W4285389733 cites W2131723216 @default.
- W4285389733 cites W2133556122 @default.
- W4285389733 cites W2138393164 @default.
- W4285389733 cites W2139133521 @default.
- W4285389733 cites W2147078478 @default.
- W4285389733 cites W2158609797 @default.
- W4285389733 cites W2160857519 @default.
- W4285389733 cites W2163870816 @default.
- W4285389733 cites W2201152614 @default.
- W4285389733 cites W2217770415 @default.
- W4285389733 cites W2295589367 @default.
- W4285389733 cites W2338917752 @default.
- W4285389733 cites W2345961196 @default.
- W4285389733 cites W2414572805 @default.
- W4285389733 cites W2466092873 @default.
- W4285389733 cites W2473135273 @default.
- W4285389733 cites W2510669564 @default.
- W4285389733 cites W2523360402 @default.
- W4285389733 cites W2562269243 @default.
- W4285389733 cites W2581009455 @default.
- W4285389733 cites W2590054733 @default.
- W4285389733 cites W2590195909 @default.
- W4285389733 cites W2603795237 @default.
- W4285389733 cites W2755673474 @default.
- W4285389733 cites W2761376093 @default.
- W4285389733 cites W2769424652 @default.
- W4285389733 cites W2792554123 @default.
- W4285389733 cites W2793209087 @default.
- W4285389733 cites W2803273233 @default.
- W4285389733 cites W2809649204 @default.
- W4285389733 cites W2884477296 @default.
- W4285389733 cites W2887487805 @default.
- W4285389733 cites W2894016122 @default.
- W4285389733 cites W2902527882 @default.
- W4285389733 cites W2911248417 @default.
- W4285389733 cites W2918882505 @default.
- W4285389733 cites W2944245644 @default.
- W4285389733 cites W2963938814 @default.
- W4285389733 cites W2986574245 @default.
- W4285389733 cites W2995831021 @default.
- W4285389733 cites W2999044305 @default.
- W4285389733 cites W3001466143 @default.
- W4285389733 cites W3022987161 @default.
- W4285389733 cites W3027960481 @default.
- W4285389733 cites W3124012008 @default.
- W4285389733 cites W3125782153 @default.
- W4285389733 cites W3127757890 @default.
- W4285389733 cites W3132448805 @default.
- W4285389733 cites W3135682489 @default.