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- W4285389910 abstract "Human β-defensin-3 (hBD-3) exhibits antimicrobial and immunomodulatory activities; however, its contribution to autophagy regulation remains unclear, and the role of autophagy in the regulation of the epidermal barrier in atopic dermatitis (AD) is poorly understood. Here, keratinocyte autophagy was restrained in the skin lesions of patients with AD and murine models of AD. Interestingly, hBD-3 alleviated the IL-4– and IL-13–mediated impairment of the tight junction (TJ) barrier through keratinocyte autophagy activation, which involved aryl hydrocarbon receptor (AhR) signaling. While autophagy deficiency impaired the epidermal barrier and exacerbated inflammation, hBD-3 attenuated skin inflammation and enhanced the TJ barrier in AD. Importantly, hBD-3–mediated improvement of the TJ barrier was abolished in autophagy-deficient AD mice and in AhR-suppressed AD mice, suggesting a role for hBD-3–mediated autophagy in the regulation of the epidermal barrier and inflammation in AD. Thus, autophagy contributes to the pathogenesis of AD, and hBD-3 could be used for therapeutic purposes." @default.
- W4285389910 created "2022-07-14" @default.
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- W4285389910 date "2022-09-01" @default.
- W4285389910 modified "2023-10-17" @default.
- W4285389910 title "Human β-defensin-3 attenuates atopic dermatitis–like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway" @default.
- W4285389910 cites W1167372180 @default.
- W4285389910 cites W1577296862 @default.
- W4285389910 cites W1586925433 @default.
- W4285389910 cites W1593555249 @default.
- W4285389910 cites W1896221069 @default.
- W4285389910 cites W1924842828 @default.
- W4285389910 cites W1963861915 @default.
- W4285389910 cites W1965457590 @default.
- W4285389910 cites W1966278842 @default.
- W4285389910 cites W1970162790 @default.
- W4285389910 cites W1970944257 @default.
- W4285389910 cites W1971896370 @default.
- W4285389910 cites W1979783084 @default.
- W4285389910 cites W1982992814 @default.
- W4285389910 cites W1990138203 @default.
- W4285389910 cites W1999306018 @default.
- W4285389910 cites W2001160077 @default.
- W4285389910 cites W2002157490 @default.
- W4285389910 cites W2002840861 @default.
- W4285389910 cites W2006749681 @default.
- W4285389910 cites W2010018906 @default.
- W4285389910 cites W2017779665 @default.
- W4285389910 cites W2019951158 @default.
- W4285389910 cites W2023782615 @default.
- W4285389910 cites W2028197167 @default.
- W4285389910 cites W2040177546 @default.
- W4285389910 cites W2040227387 @default.
- W4285389910 cites W2044003126 @default.
- W4285389910 cites W2044280032 @default.
- W4285389910 cites W2052631233 @default.
- W4285389910 cites W2059734717 @default.
- W4285389910 cites W2060505238 @default.
- W4285389910 cites W2074648420 @default.
- W4285389910 cites W2078255866 @default.
- W4285389910 cites W2078724064 @default.
- W4285389910 cites W2090208256 @default.
- W4285389910 cites W2092847593 @default.
- W4285389910 cites W2098225479 @default.
- W4285389910 cites W2098789167 @default.
- W4285389910 cites W2098839791 @default.
- W4285389910 cites W2099367536 @default.
- W4285389910 cites W2104159258 @default.
- W4285389910 cites W2104558541 @default.
- W4285389910 cites W2115586190 @default.
- W4285389910 cites W2116367518 @default.
- W4285389910 cites W2117159275 @default.
- W4285389910 cites W2121580723 @default.
- W4285389910 cites W2132024007 @default.
- W4285389910 cites W2146887271 @default.
- W4285389910 cites W2148115712 @default.
- W4285389910 cites W2148911704 @default.
- W4285389910 cites W2151197941 @default.
- W4285389910 cites W2154008739 @default.
- W4285389910 cites W2156171182 @default.
- W4285389910 cites W2166021357 @default.
- W4285389910 cites W2167810415 @default.
- W4285389910 cites W2196195787 @default.
- W4285389910 cites W2305435220 @default.
- W4285389910 cites W2474553364 @default.
- W4285389910 cites W2736056004 @default.
- W4285389910 cites W2751819051 @default.
- W4285389910 cites W2759289413 @default.
- W4285389910 cites W2784022040 @default.
- W4285389910 cites W2792155253 @default.
- W4285389910 cites W2793257861 @default.
- W4285389910 cites W2807435395 @default.
- W4285389910 cites W2911962886 @default.
- W4285389910 cites W2946259093 @default.
- W4285389910 cites W2960510458 @default.
- W4285389910 cites W2964399871 @default.
- W4285389910 cites W2988915271 @default.
- W4285389910 cites W3005189635 @default.
- W4285389910 cites W3023200455 @default.
- W4285389910 cites W3025777610 @default.
- W4285389910 cites W3092676806 @default.
- W4285389910 cites W3093055572 @default.