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- W4285390258 abstract "Salmonella enterica serovar Pullorum ( S . Pullorum) is a host-specific pathogen, which causes acute gastroenteritis with high mortality in poultry. However, the association between steE , encoded by type III secretion system 2, and Salmonella virulence is not well-understood. To elucidate the functions of steE in S . Pullorum, Δ steE strain was constructed using the λ-Red recombination technology. Compared to that in the wild-type, the deletion of steE in S . Pullorum reduced bacterial invasion, proliferation, and late apoptosis in the infected HD-11 cells. In addition, we analyzed the mRNA expression levels of effector genes and cytokines by qRT-PCR. SteE was associated with the regulation of various effector genes and inflammatory cytokines in HD-11 cells during S . Pullorum infection. The wild-type effector steE promoted the expression of anti-inflammatory cytokines (IL-4 and IL-10) and reduced that of pro-inflammatory cytokines (IL-1β, IL-6, and IL-12) compared to that in the Δ steE -infected HD-11 cells and chicken spleens. Results from the chicken infection model showed that the deletion of steE resulted in significantly decreased colonization and long-term survival of the bacteria and alleviated pathological lesions compared to those in the wild-type. Further, steE increased the virulence of S . Pullorum in chickens by regulating the expression of inflammatory cytokines. Our findings provide insights into the persistent infection and autoimmunity associated with steE in S . Pullorum." @default.
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- W4285390258 date "2022-07-14" @default.
- W4285390258 modified "2023-10-18" @default.
- W4285390258 title "SteE Enhances the Virulence of Salmonella Pullorum in Chickens by Regulating the Inflammation Response" @default.
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- W4285390258 doi "https://doi.org/10.3389/fvets.2022.926505" @default.
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