Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285391159> ?p ?o ?g. }
- W4285391159 abstract "Abstract Transcriptional enhancers regulate gene expression in a developmental-stage and cell-specific manner. They were originally defined as individual regulatory elements that activate expression regardless of distance and orientation to their cognate genes. Genome-wide studies have shown that the mammalian enhancer landscape is much more complex, with different classes of individual enhancers and clusters of enhancer-like elements combining in additive, synergistic and redundant manners, possibly acting as single, integrated regulatory elements. These so-called super-enhancers are largely defined as clusters of enhancer-like elements which recruit particularly high levels of Mediator and often drive high levels of expression of key lineage-specific genes. Here, we analysed 78 erythroid-specific super-enhancers and showed that, as units, they preferentially interact in a directional manner, to drive expression of their cognate genes. Using the well characterised α-globin super-enhancer, we show that inverting this entire structure severely downregulates α-globin expression and activates flanking genes 5’ of the super-enhancer. Our detailed genetic dissection of the α-globin locus clearly attributes the cluster’s functional directionality to its sequence orientation, demonstrating that, unlike regular enhancers, super-enhancers act in an orientation-dependent manner. Together, these findings identify a novel emergent property of super-enhancers and revise current models by which enhancers are thought to contact and activate their cognate genes." @default.
- W4285391159 created "2022-07-14" @default.
- W4285391159 creator A5005500986 @default.
- W4285391159 creator A5006637842 @default.
- W4285391159 creator A5011154503 @default.
- W4285391159 creator A5014058517 @default.
- W4285391159 creator A5014949168 @default.
- W4285391159 creator A5015870619 @default.
- W4285391159 creator A5020959667 @default.
- W4285391159 creator A5037946672 @default.
- W4285391159 creator A5042064951 @default.
- W4285391159 creator A5044330602 @default.
- W4285391159 creator A5044446961 @default.
- W4285391159 creator A5051032516 @default.
- W4285391159 creator A5051112684 @default.
- W4285391159 creator A5054485083 @default.
- W4285391159 creator A5059302506 @default.
- W4285391159 creator A5065363960 @default.
- W4285391159 creator A5077835589 @default.
- W4285391159 creator A5086923541 @default.
- W4285391159 creator A5091224445 @default.
- W4285391159 creator A5028552414 @default.
- W4285391159 date "2022-07-14" @default.
- W4285391159 modified "2023-10-17" @default.
- W4285391159 title "Multipartite super-enhancers function in an orientation-dependent manner" @default.
- W4285391159 cites W1496551672 @default.
- W4285391159 cites W1831401007 @default.
- W4285391159 cites W1855348513 @default.
- W4285391159 cites W1873772354 @default.
- W4285391159 cites W1941076503 @default.
- W4285391159 cites W1971578941 @default.
- W4285391159 cites W1973062929 @default.
- W4285391159 cites W1973796285 @default.
- W4285391159 cites W1974223852 @default.
- W4285391159 cites W1981309824 @default.
- W4285391159 cites W1982661746 @default.
- W4285391159 cites W1992213480 @default.
- W4285391159 cites W2000681972 @default.
- W4285391159 cites W2010427181 @default.
- W4285391159 cites W2029492292 @default.
- W4285391159 cites W2036513942 @default.
- W4285391159 cites W2037886921 @default.
- W4285391159 cites W2038218774 @default.
- W4285391159 cites W2042930277 @default.
- W4285391159 cites W2045362835 @default.
- W4285391159 cites W2047072851 @default.
- W4285391159 cites W2051763116 @default.
- W4285391159 cites W2066078097 @default.
- W4285391159 cites W2070021921 @default.
- W4285391159 cites W2075685244 @default.
- W4285391159 cites W2107665951 @default.
- W4285391159 cites W2111953718 @default.
- W4285391159 cites W2117757143 @default.
- W4285391159 cites W2124627130 @default.
- W4285391159 cites W2128016314 @default.
- W4285391159 cites W2128151873 @default.
- W4285391159 cites W2128531085 @default.
- W4285391159 cites W2130578474 @default.
- W4285391159 cites W2133484520 @default.
- W4285391159 cites W2141340108 @default.
- W4285391159 cites W2148720354 @default.
- W4285391159 cites W2161212572 @default.
- W4285391159 cites W2169456326 @default.
- W4285391159 cites W2170551349 @default.
- W4285391159 cites W2173155483 @default.
- W4285391159 cites W2259938310 @default.
- W4285391159 cites W2341539131 @default.
- W4285391159 cites W2401568148 @default.
- W4285391159 cites W2411956266 @default.
- W4285391159 cites W2462894283 @default.
- W4285391159 cites W2464000940 @default.
- W4285391159 cites W2548430945 @default.
- W4285391159 cites W2556513628 @default.
- W4285391159 cites W2557493613 @default.
- W4285391159 cites W2567174107 @default.
- W4285391159 cites W2607008467 @default.
- W4285391159 cites W2614144400 @default.
- W4285391159 cites W2725576187 @default.
- W4285391159 cites W2736857446 @default.
- W4285391159 cites W2742861490 @default.
- W4285391159 cites W2747734803 @default.
- W4285391159 cites W2757387674 @default.
- W4285391159 cites W2761461280 @default.
- W4285391159 cites W2796109902 @default.
- W4285391159 cites W2800216985 @default.
- W4285391159 cites W2808847099 @default.
- W4285391159 cites W2809057270 @default.
- W4285391159 cites W2809265915 @default.
- W4285391159 cites W2885191058 @default.
- W4285391159 cites W2888200508 @default.
- W4285391159 cites W2894289085 @default.
- W4285391159 cites W2898577086 @default.
- W4285391159 cites W2901209536 @default.
- W4285391159 cites W2906884244 @default.
- W4285391159 cites W2945999435 @default.
- W4285391159 cites W2965729444 @default.
- W4285391159 cites W2971199992 @default.
- W4285391159 cites W2999585791 @default.
- W4285391159 cites W3006529305 @default.
- W4285391159 cites W3007330226 @default.