FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285391968> ?p ?o ?g. }

• W4285391968 endingPage "1055" @default.
• W4285391968 startingPage "1055" @default.
• W4285391968 abstract "Enteroviruses such as group B coxsackieviruses (CVB) are commonly suspected as causes of myocarditis that can lead to dilated cardiomyopathy (DCM), and the mouse model of CVB3 myocarditis is routinely used to understand DCM pathogenesis. Mechanistically, autoimmunity is suspected due to the presence of autoantibodies for select antigens. However, their role continues to be enigmatic, which also raises the question of whether the breadth of autoantibodies is sufficiently characterized. Here, we attempted to comprehensively analyze the autoantibody repertoire using Phage ImmunoPrecipitation Sequencing (PhIP-Seq), a versatile and high-throughput platform, in the mouse model of CVB3 myocarditis. First, PhIP-Seq analysis using the VirScan library revealed antibody reactivity only to CVB3 in the infected group but not in controls, thus validating the technique in this model. Second, using the mouse peptide library, we detected autoantibodies to 32 peptides from 25 proteins in infected animals that are ubiquitously expressed and have not been previously reported. Third, by using ELISA as a secondary assay, we confirmed antibody reactivity in sera from CVB3-infected animals to cytochrome c oxidase assembly factor 4 homolog (COA4) and phosphoinositide-3-kinase adaptor protein 1 (PIK3AP1), indicating the specificity of antibody detection by PhIP-Seq technology. Fourth, we noted similar antibody reactivity patterns in CVB3 and CVB4 infections, suggesting that the COA4- and PIK3AP1-reactive antibodies could be common to multiple CVB infections. The specificity of the autoantibodies was affirmed with influenza-infected animals that showed no reactivity to any of the antigens tested. Taken together, our data suggest that the autoantibodies identified by PhIP-Seq may have relevance to CVB pathogenesis, with a possibility that similar reactivity could be expected in human DCM patients." @default.
• W4285391968 created "2022-07-14" @default.
• W4285391968 creator A5012708409 @default.
• W4285391968 creator A5023793327 @default.
• W4285391968 creator A5025626996 @default.
• W4285391968 creator A5034754268 @default.
• W4285391968 creator A5039426475 @default.
• W4285391968 creator A5042986773 @default.
• W4285391968 creator A5059663009 @default.
• W4285391968 creator A5060845933 @default.
• W4285391968 creator A5063533784 @default.
• W4285391968 date "2022-07-13" @default.
• W4285391968 modified "2023-10-17" @default.
• W4285391968 title "PhIP-Seq Reveals Autoantibodies for Ubiquitously Expressed Antigens in Viral Myocarditis" @default.
• W4285391968 cites W142542448 @default.
• W4285391968 cites W1522688657 @default.
• W4285391968 cites W1576117414 @default.
• W4285391968 cites W1578923163 @default.
• W4285391968 cites W1582112095 @default.
• W4285391968 cites W1900892538 @default.
• W4285391968 cites W1972277006 @default.
• W4285391968 cites W1977736910 @default.
• W4285391968 cites W1978265573 @default.
• W4285391968 cites W1978868651 @default.
• W4285391968 cites W1980444116 @default.
• W4285391968 cites W1985235249 @default.
• W4285391968 cites W1985921653 @default.
• W4285391968 cites W1998393744 @default.
• W4285391968 cites W1998702086 @default.
• W4285391968 cites W2004490529 @default.
• W4285391968 cites W2012671933 @default.
• W4285391968 cites W2017948161 @default.
• W4285391968 cites W2023298316 @default.
• W4285391968 cites W2024594419 @default.
• W4285391968 cites W2029077196 @default.
• W4285391968 cites W2041181510 @default.
• W4285391968 cites W2047585875 @default.
• W4285391968 cites W2057801650 @default.
• W4285391968 cites W2066555241 @default.
• W4285391968 cites W2080805948 @default.
• W4285391968 cites W2082796552 @default.
• W4285391968 cites W2085018624 @default.
• W4285391968 cites W2085467917 @default.
• W4285391968 cites W2085568008 @default.
• W4285391968 cites W2088480409 @default.
• W4285391968 cites W2097728608 @default.
• W4285391968 cites W2104939328 @default.
• W4285391968 cites W2105097400 @default.
• W4285391968 cites W2110918404 @default.
• W4285391968 cites W2115777466 @default.
• W4285391968 cites W2116688916 @default.
• W4285391968 cites W2126113000 @default.
• W4285391968 cites W2135701801 @default.
• W4285391968 cites W2137514919 @default.
• W4285391968 cites W2144876663 @default.
• W4285391968 cites W2154533992 @default.
• W4285391968 cites W2161695785 @default.
• W4285391968 cites W2273527755 @default.
• W4285391968 cites W2312220900 @default.
• W4285391968 cites W2415984744 @default.
• W4285391968 cites W2549096308 @default.
• W4285391968 cites W2550055437 @default.
• W4285391968 cites W2588631233 @default.
• W4285391968 cites W2590602763 @default.
• W4285391968 cites W2746387345 @default.
• W4285391968 cites W2756251699 @default.
• W4285391968 cites W2773081165 @default.
• W4285391968 cites W2890891844 @default.
• W4285391968 cites W2900561864 @default.
• W4285391968 cites W2921439506 @default.
• W4285391968 cites W2931300620 @default.
• W4285391968 cites W2946040590 @default.
• W4285391968 cites W2953728338 @default.
• W4285391968 cites W2953957924 @default.
• W4285391968 cites W2967972886 @default.
• W4285391968 cites W2989570755 @default.
• W4285391968 cites W2995990372 @default.
• W4285391968 cites W3010756867 @default.
• W4285391968 cites W3013486740 @default.
• W4285391968 cites W3023630330 @default.
• W4285391968 cites W3025141660 @default.
• W4285391968 cites W3032729016 @default.
• W4285391968 cites W3034594171 @default.
• W4285391968 cites W3040042837 @default.
• W4285391968 cites W3045497278 @default.
• W4285391968 cites W3084924559 @default.
• W4285391968 cites W3092415006 @default.
• W4285391968 cites W3129605110 @default.
• W4285391968 cites W3130849732 @default.
• W4285391968 cites W3170563592 @default.
• W4285391968 cites W3207552006 @default.
• W4285391968 cites W3211970710 @default.
• W4285391968 cites W39680182 @default.
• W4285391968 cites W4200217775 @default.
• W4285391968 cites W4250644578 @default.
• W4285391968 cites W4280517794 @default.
• W4285391968 cites W4281646402 @default.
• W4285391968 doi "https://doi.org/10.3390/biology11071055" @default.

• next