Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285392335> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W4285392335 abstract "There has been considerable scientific effort dedicated to understanding the biologic consequence and therapeutic implications of aberrant tryptophan metabolism in brain tumors and neurodegenerative diseases. An overwhelming majority of this work has focused on the upstream metabolism of tryptophan; however, this has not resulted in clinical application. Using global metabolomic profiling of patient-derived brain tumors, we identify the downstream metabolism of tryptophan and accumulation of quinolinate (QA) as a metabolic node in glioblastoma and went on to demonstrate its critical role in promoting immune tolerance. QA acts as a metabolic checkpoint in glioblastoma by inducing NMDA receptor activation and Foxo1/PPARg; signaling, resulting in amplification of immune suppressive macrophages. Using a genetically-engineered mouse model designed to inhibit production of QA, we identify kynureninase as a promising therapeutic target to revert the potent immune suppressive microenvironment in glioblastoma. These findings offer the scientific community an opportunity to revisit the biologic consequence of this pathway as it relates to oncogenesis and neurodegenerative disease and a framework for developing new immune modulatory agents to further clinical gains in these otherwise incurable diseases." @default.
- W4285392335 created "2022-07-14" @default.
- W4285392335 creator A5012668473 @default.
- W4285392335 creator A5031142519 @default.
- W4285392335 creator A5042190375 @default.
- W4285392335 creator A5063868352 @default.
- W4285392335 date "2022-07-13" @default.
- W4285392335 modified "2023-10-16" @default.
- W4285392335 title "Quinolinate promotes alternatively activated macrophage-induced immune tolerance in glioblastoma through the NMDA/PPARγ signaling axis" @default.
- W4285392335 doi "https://doi.org/10.1101/2022.07.12.499609" @default.
- W4285392335 hasPublicationYear "2022" @default.
- W4285392335 type Work @default.
- W4285392335 citedByCount "0" @default.
- W4285392335 crossrefType "posted-content" @default.
- W4285392335 hasAuthorship W4285392335A5012668473 @default.
- W4285392335 hasAuthorship W4285392335A5031142519 @default.
- W4285392335 hasAuthorship W4285392335A5042190375 @default.
- W4285392335 hasAuthorship W4285392335A5063868352 @default.
- W4285392335 hasBestOaLocation W42853923351 @default.
- W4285392335 hasConcept C169760540 @default.
- W4285392335 hasConcept C203014093 @default.
- W4285392335 hasConcept C2776107976 @default.
- W4285392335 hasConcept C2776706248 @default.
- W4285392335 hasConcept C2776710720 @default.
- W4285392335 hasConcept C2777503454 @default.
- W4285392335 hasConcept C2777896816 @default.
- W4285392335 hasConcept C2910635417 @default.
- W4285392335 hasConcept C502942594 @default.
- W4285392335 hasConcept C515207424 @default.
- W4285392335 hasConcept C55493867 @default.
- W4285392335 hasConcept C86803240 @default.
- W4285392335 hasConcept C8891405 @default.
- W4285392335 hasConceptScore W4285392335C169760540 @default.
- W4285392335 hasConceptScore W4285392335C203014093 @default.
- W4285392335 hasConceptScore W4285392335C2776107976 @default.
- W4285392335 hasConceptScore W4285392335C2776706248 @default.
- W4285392335 hasConceptScore W4285392335C2776710720 @default.
- W4285392335 hasConceptScore W4285392335C2777503454 @default.
- W4285392335 hasConceptScore W4285392335C2777896816 @default.
- W4285392335 hasConceptScore W4285392335C2910635417 @default.
- W4285392335 hasConceptScore W4285392335C502942594 @default.
- W4285392335 hasConceptScore W4285392335C515207424 @default.
- W4285392335 hasConceptScore W4285392335C55493867 @default.
- W4285392335 hasConceptScore W4285392335C86803240 @default.
- W4285392335 hasConceptScore W4285392335C8891405 @default.
- W4285392335 hasLocation W42853923351 @default.
- W4285392335 hasOpenAccess W4285392335 @default.
- W4285392335 hasPrimaryLocation W42853923351 @default.
- W4285392335 hasRelatedWork W1563043670 @default.
- W4285392335 hasRelatedWork W1782672155 @default.
- W4285392335 hasRelatedWork W1788048720 @default.
- W4285392335 hasRelatedWork W1971242889 @default.
- W4285392335 hasRelatedWork W1993293666 @default.
- W4285392335 hasRelatedWork W2048758222 @default.
- W4285392335 hasRelatedWork W2088325268 @default.
- W4285392335 hasRelatedWork W2128046071 @default.
- W4285392335 hasRelatedWork W2286983402 @default.
- W4285392335 hasRelatedWork W50490921 @default.
- W4285392335 isParatext "false" @default.
- W4285392335 isRetracted "false" @default.
- W4285392335 workType "article" @default.