FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285393312> ?p ?o ?g. }

• W4285393312 abstract "Abstract Latin America continues to be severely underrepresented in genomics research, and fine-scale genetic histories as well as complex trait architectures remain hidden due to the lack of Big Data. To fill this gap, the Mexican Biobank project genotyped 1.8 million markers in 6,057 individuals from 32 states and 898 sampling localities across Mexico with linked complex trait and disease information creating a valuable nationwide genotype-phenotype database. Through a suite of state-of-the-art methods for ancestry deconvolution and inference of identity-by-descent (IBD) segments, we inferred detailed ancestral histories for the last 200 generations in different Mesoamerican regions, unraveling native and colonial/post-colonial demographic dynamics. We observed large variations in runs of homozygosity (ROH) among genomic regions with different ancestral origins reflecting their demographic histories, which also affect the distribution of rare deleterious variants across Mexico. We analyzed a range of biomedical complex traits and identified significant genetic and environmental factors explaining their variation, such as ROH found to be significant predictors for trait variation in BMI and triglycerides." @default.
• W4285393312 created "2022-07-14" @default.
• W4285393312 creator A5000274356 @default.
• W4285393312 creator A5005019504 @default.
• W4285393312 creator A5007971858 @default.
• W4285393312 creator A5014777785 @default.
• W4285393312 creator A5019032304 @default.
• W4285393312 creator A5022771117 @default.
• W4285393312 creator A5024704031 @default.
• W4285393312 creator A5027632811 @default.
• W4285393312 creator A5029267040 @default.
• W4285393312 creator A5036329007 @default.
• W4285393312 creator A5037138357 @default.
• W4285393312 creator A5040465902 @default.
• W4285393312 creator A5042879556 @default.
• W4285393312 creator A5044713317 @default.
• W4285393312 creator A5046004580 @default.
• W4285393312 creator A5046827968 @default.
• W4285393312 creator A5048170608 @default.
• W4285393312 creator A5057235236 @default.
• W4285393312 creator A5065960717 @default.
• W4285393312 creator A5068456674 @default.
• W4285393312 creator A5071291340 @default.
• W4285393312 creator A5071447885 @default.
• W4285393312 creator A5072029606 @default.
• W4285393312 creator A5073718055 @default.
• W4285393312 creator A5077936005 @default.
• W4285393312 creator A5086266728 @default.
• W4285393312 creator A5087718113 @default.
• W4285393312 creator A5089504276 @default.
• W4285393312 date "2022-07-13" @default.
• W4285393312 modified "2023-10-12" @default.
• W4285393312 title "Nationwide genomic biobank in Mexico unravels demographic history and complex trait architecture from 6,057 individuals" @default.
• W4285393312 cites W1573669151 @default.
• W4285393312 cites W1919419508 @default.
• W4285393312 cites W1994975196 @default.
• W4285393312 cites W2048244934 @default.
• W4285393312 cites W2059748199 @default.
• W4285393312 cites W2068378322 @default.
• W4285393312 cites W2087437533 @default.
• W4285393312 cites W2102714321 @default.
• W4285393312 cites W2104549677 @default.
• W4285393312 cites W2119444539 @default.
• W4285393312 cites W2133148918 @default.
• W4285393312 cites W2166064778 @default.
• W4285393312 cites W2217029310 @default.
• W4285393312 cites W2493617894 @default.
• W4285393312 cites W2531587846 @default.
• W4285393312 cites W2610508058 @default.
• W4285393312 cites W2761092684 @default.
• W4285393312 cites W2784309373 @default.
• W4285393312 cites W2804696428 @default.
• W4285393312 cites W2952013316 @default.
• W4285393312 cites W2971577868 @default.
• W4285393312 cites W2996217902 @default.
• W4285393312 cites W3116604779 @default.
• W4285393312 cites W3196332378 @default.
• W4285393312 cites W3199784335 @default.
• W4285393312 cites W3205637413 @default.
• W4285393312 cites W4224029833 @default.
• W4285393312 cites W4242237624 @default.
• W4285393312 cites W620605833 @default.
• W4285393312 doi "https://doi.org/10.1101/2022.07.11.499652" @default.
• W4285393312 hasPublicationYear "2022" @default.
• W4285393312 type Work @default.
• W4285393312 citedByCount "4" @default.
• W4285393312 countsByYear W42853933122023 @default.
• W4285393312 crossrefType "posted-content" @default.
• W4285393312 hasAuthorship W4285393312A5000274356 @default.
• W4285393312 hasAuthorship W4285393312A5005019504 @default.
• W4285393312 hasAuthorship W4285393312A5007971858 @default.
• W4285393312 hasAuthorship W4285393312A5014777785 @default.
• W4285393312 hasAuthorship W4285393312A5019032304 @default.
• W4285393312 hasAuthorship W4285393312A5022771117 @default.
• W4285393312 hasAuthorship W4285393312A5024704031 @default.
• W4285393312 hasAuthorship W4285393312A5027632811 @default.
• W4285393312 hasAuthorship W4285393312A5029267040 @default.
• W4285393312 hasAuthorship W4285393312A5036329007 @default.
• W4285393312 hasAuthorship W4285393312A5037138357 @default.
• W4285393312 hasAuthorship W4285393312A5040465902 @default.
• W4285393312 hasAuthorship W4285393312A5042879556 @default.
• W4285393312 hasAuthorship W4285393312A5044713317 @default.
• W4285393312 hasAuthorship W4285393312A5046004580 @default.
• W4285393312 hasAuthorship W4285393312A5046827968 @default.
• W4285393312 hasAuthorship W4285393312A5048170608 @default.
• W4285393312 hasAuthorship W4285393312A5057235236 @default.
• W4285393312 hasAuthorship W4285393312A5065960717 @default.
• W4285393312 hasAuthorship W4285393312A5068456674 @default.
• W4285393312 hasAuthorship W4285393312A5071291340 @default.
• W4285393312 hasAuthorship W4285393312A5071447885 @default.
• W4285393312 hasAuthorship W4285393312A5072029606 @default.
• W4285393312 hasAuthorship W4285393312A5073718055 @default.
• W4285393312 hasAuthorship W4285393312A5077936005 @default.
• W4285393312 hasAuthorship W4285393312A5086266728 @default.
• W4285393312 hasAuthorship W4285393312A5087718113 @default.
• W4285393312 hasAuthorship W4285393312A5089504276 @default.
• W4285393312 hasBestOaLocation W42853933121 @default.
• W4285393312 hasConcept C104317684 @default.
• W4285393312 hasConcept C106934330 @default.
• W4285393312 hasConcept C116567970 @default.

• next