FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285394073> ?p ?o ?g. }

• W4285394073 abstract "The use of psychotropics is high among the older population and may have detrimental effects on their physical and mental health. Cardiorespiratory fitness (CRF) is a strong and modifiable measure of health and declines with age. We aimed to study the association of change in CRF with use of psychotropics in community-dwelling older adults.We analyzed longitudinal data from 1531 older adults from the Generation 100 study, aged 70-77 years at inclusion, and with a permanent address in Trondheim, Norway. Data on objectively measured peak oxygen uptake (VO2peak) were linked with register data from the Norwegian Prescription Database on prescribed psychotropics. The included psychotropics were antidepressants (N06A), antipsychotics (N05A), anxiolytics (N05B), hypnotics and sedatives (N05C), and N03AE (benzodiazepine derivatives). Analyses were done on any psychotropics as one group, and on the following separate groups: antidepressants (N06A), benzodiazepines (N05BA, N05CD, and N03AE), and z-hypnotics (N05CF). Peak oxygen uptake was measured four times over a five-year period and corresponding medication use was measured as defined daily doses (DDD). A random effects estimator was applied to investigate the association of change in VO2peak with the use of psychotropics.We found a statistically significant curvilinear association of change in VO2peak with use of any psychotropics and antidepressants. For VO2peak up to ~ 40 ml/kg/min, each 1 ml/kg/min increase was associated by a 3.3 DDD and 2.5 DDD decrease in use of any psychotropics and antidepressants, respectively. A bottoming-out effect was found and increases in VO2peak above ~ 40 ml/kg/min showed increased use of any psychotropics and antidepressants. However, the association of change in VO2peak with use was stronger for changes in the lower continuum of VO2peak levels and decreased with increasing VO2peak. No statistically significant association of change in VO2peak with use of benzodiazepines and z-hypnotics were found. However, because of a non-randomized design, we cannot rule out the possibility of confounding by indication.The results of this study show a curvilinear association of change in VO2peak with use of any psychotropics and antidepressants in older adults. This relationship adds a new viewpoint on the adverse effects of psychotropic use and should be considered in interventions and policies aimed at reducing psychotropic medication use among the older population." @default.
• W4285394073 created "2022-07-14" @default.
• W4285394073 creator A5038917567 @default.
• W4285394073 creator A5042054840 @default.
• W4285394073 creator A5049543739 @default.
• W4285394073 creator A5056847820 @default.
• W4285394073 creator A5087027581 @default.
• W4285394073 date "2022-07-13" @default.
• W4285394073 modified "2023-10-14" @default.
• W4285394073 title "The association of change in peak oxygen uptake with use of psychotropics in community-dwelling older adults - The Generation 100 study" @default.
• W4285394073 cites W1657151749 @default.
• W4285394073 cites W1759511408 @default.
• W4285394073 cites W1826758346 @default.
• W4285394073 cites W1964048724 @default.
• W4285394073 cites W1982330334 @default.
• W4285394073 cites W2004530445 @default.
• W4285394073 cites W2044985256 @default.
• W4285394073 cites W2046481462 @default.
• W4285394073 cites W2067911406 @default.
• W4285394073 cites W2095423498 @default.
• W4285394073 cites W2107857010 @default.
• W4285394073 cites W2132714657 @default.
• W4285394073 cites W2147717090 @default.
• W4285394073 cites W2149485684 @default.
• W4285394073 cites W2153485698 @default.
• W4285394073 cites W2161382589 @default.
• W4285394073 cites W2168816510 @default.
• W4285394073 cites W2310115806 @default.
• W4285394073 cites W2493575966 @default.
• W4285394073 cites W2555189237 @default.
• W4285394073 cites W2559338735 @default.
• W4285394073 cites W2582238443 @default.
• W4285394073 cites W2612713031 @default.
• W4285394073 cites W2783977704 @default.
• W4285394073 cites W2792628329 @default.
• W4285394073 cites W2823921636 @default.
• W4285394073 cites W2905104895 @default.
• W4285394073 cites W2958971346 @default.
• W4285394073 cites W2964850361 @default.
• W4285394073 cites W2979021191 @default.
• W4285394073 cites W3010844243 @default.
• W4285394073 cites W3090766412 @default.
• W4285394073 cites W3091993604 @default.
• W4285394073 cites W3103926746 @default.
• W4285394073 cites W3191603679 @default.
• W4285394073 cites W3194905005 @default.
• W4285394073 doi "https://doi.org/10.1186/s12877-022-03262-6" @default.
• W4285394073 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35831807" @default.
• W4285394073 hasPublicationYear "2022" @default.
• W4285394073 type Work @default.
• W4285394073 citedByCount "1" @default.
• W4285394073 countsByYear W42853940732023 @default.
• W4285394073 crossrefType "journal-article" @default.
• W4285394073 hasAuthorship W4285394073A5038917567 @default.
• W4285394073 hasAuthorship W4285394073A5042054840 @default.
• W4285394073 hasAuthorship W4285394073A5049543739 @default.
• W4285394073 hasAuthorship W4285394073A5056847820 @default.
• W4285394073 hasAuthorship W4285394073A5087027581 @default.
• W4285394073 hasBestOaLocation W42853940731 @default.
• W4285394073 hasConcept C117437137 @default.
• W4285394073 hasConcept C126322002 @default.
• W4285394073 hasConcept C1862650 @default.
• W4285394073 hasConcept C196310339 @default.
• W4285394073 hasConcept C2426938 @default.
• W4285394073 hasConcept C2777953023 @default.
• W4285394073 hasConcept C2908647359 @default.
• W4285394073 hasConcept C71924100 @default.
• W4285394073 hasConcept C84393581 @default.
• W4285394073 hasConcept C98274493 @default.
• W4285394073 hasConcept C99454951 @default.
• W4285394073 hasConceptScore W4285394073C117437137 @default.
• W4285394073 hasConceptScore W4285394073C126322002 @default.
• W4285394073 hasConceptScore W4285394073C1862650 @default.
• W4285394073 hasConceptScore W4285394073C196310339 @default.
• W4285394073 hasConceptScore W4285394073C2426938 @default.
• W4285394073 hasConceptScore W4285394073C2777953023 @default.
• W4285394073 hasConceptScore W4285394073C2908647359 @default.
• W4285394073 hasConceptScore W4285394073C71924100 @default.
• W4285394073 hasConceptScore W4285394073C84393581 @default.
• W4285394073 hasConceptScore W4285394073C98274493 @default.
• W4285394073 hasConceptScore W4285394073C99454951 @default.
• W4285394073 hasIssue "1" @default.
• W4285394073 hasLocation W42853940731 @default.
• W4285394073 hasLocation W42853940732 @default.
• W4285394073 hasLocation W42853940733 @default.
• W4285394073 hasLocation W42853940734 @default.
• W4285394073 hasOpenAccess W4285394073 @default.
• W4285394073 hasPrimaryLocation W42853940731 @default.
• W4285394073 hasRelatedWork W171780804 @default.
• W4285394073 hasRelatedWork W1972133312 @default.
• W4285394073 hasRelatedWork W2087411862 @default.
• W4285394073 hasRelatedWork W2198065975 @default.
• W4285394073 hasRelatedWork W2408319187 @default.
• W4285394073 hasRelatedWork W2908696534 @default.
• W4285394073 hasRelatedWork W3037078230 @default.
• W4285394073 hasRelatedWork W4220728825 @default.
• W4285394073 hasRelatedWork W4312770467 @default.
• W4285394073 hasRelatedWork W4362701896 @default.
• W4285394073 hasVolume "22" @default.
• W4285394073 isParatext "false" @default.

• next