Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285394212> ?p ?o ?g. }
- W4285394212 abstract "We have previously demonstrated the in vivo chemopreventive efficacy of flavokawain A (FKA), a novel chalcone from the kava plant, in prostate carcinogenesis models. However, the mechanisms of the anticarcinogenic effects of FKA remain largely unknown. We evaluated the effect of FKA on prostate tumor spheroid formation by prostate cancer stem cells, which were sorted out from CD44+/CD133+ prostate cancer cells 22Rv1 and DU145. FKA treatment significantly decreased both the size and numbers of the tumor spheroids over different generations of spheroid passages. In addition, the dietary feeding of FKA-formulated food to Nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice bearing CD44+/CD133+ 22Rv1 xenograft tumors resulted in a significant reduction of tumor growth compared to those fed with vehicle control food-fed mice. Furthermore, the expression of stem cell markers, such as Nanog, Oct4, and CD44, were markedly downregulated in both tumor spheroids and tumor tissues. We also observed that FKA inhibits Ubc12 neddylation, c-Myc, and keratin-8 expression in both CD44+/CD133+ prostate tumor spheroids and xenograft tumors. Our results suggest that FKA can reduce the tumor-initiating properties and stemness of prostate cancer, which provides a new mechanism for the chemoprevention efficacy of FKA." @default.
- W4285394212 created "2022-07-14" @default.
- W4285394212 creator A5006056236 @default.
- W4285394212 creator A5009875962 @default.
- W4285394212 creator A5012683612 @default.
- W4285394212 creator A5014658993 @default.
- W4285394212 creator A5015617457 @default.
- W4285394212 creator A5029026130 @default.
- W4285394212 creator A5036496290 @default.
- W4285394212 creator A5037709572 @default.
- W4285394212 creator A5041515779 @default.
- W4285394212 creator A5057524030 @default.
- W4285394212 creator A5070093833 @default.
- W4285394212 creator A5073821889 @default.
- W4285394212 date "2022-07-13" @default.
- W4285394212 modified "2023-09-30" @default.
- W4285394212 title "Flavokawain A Reduces Tumor-Initiating Properties and Stemness of Prostate Cancer" @default.
- W4285394212 cites W131820709 @default.
- W4285394212 cites W2001827754 @default.
- W4285394212 cites W2020773324 @default.
- W4285394212 cites W2032580087 @default.
- W4285394212 cites W2077669730 @default.
- W4285394212 cites W2081737065 @default.
- W4285394212 cites W2097241191 @default.
- W4285394212 cites W2109526314 @default.
- W4285394212 cites W2147200519 @default.
- W4285394212 cites W2153382986 @default.
- W4285394212 cites W2271008339 @default.
- W4285394212 cites W2337038077 @default.
- W4285394212 cites W2349288993 @default.
- W4285394212 cites W2414833252 @default.
- W4285394212 cites W2514594194 @default.
- W4285394212 cites W2765683432 @default.
- W4285394212 cites W2775668924 @default.
- W4285394212 cites W2783028755 @default.
- W4285394212 cites W2791588343 @default.
- W4285394212 cites W2796316131 @default.
- W4285394212 cites W2803361288 @default.
- W4285394212 cites W2806604034 @default.
- W4285394212 cites W2920664576 @default.
- W4285394212 cites W2943760001 @default.
- W4285394212 cites W2952316591 @default.
- W4285394212 cites W2977131940 @default.
- W4285394212 cites W2990632174 @default.
- W4285394212 cites W3041588542 @default.
- W4285394212 cites W3042456519 @default.
- W4285394212 cites W3047693299 @default.
- W4285394212 cites W3157333084 @default.
- W4285394212 cites W3174487229 @default.
- W4285394212 cites W3174796821 @default.
- W4285394212 cites W4206841660 @default.
- W4285394212 cites W4214655144 @default.
- W4285394212 doi "https://doi.org/10.3389/fonc.2022.943846" @default.
- W4285394212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35912174" @default.
- W4285394212 hasPublicationYear "2022" @default.
- W4285394212 type Work @default.
- W4285394212 citedByCount "3" @default.
- W4285394212 countsByYear W42853942122023 @default.
- W4285394212 crossrefType "journal-article" @default.
- W4285394212 hasAuthorship W4285394212A5006056236 @default.
- W4285394212 hasAuthorship W4285394212A5009875962 @default.
- W4285394212 hasAuthorship W4285394212A5012683612 @default.
- W4285394212 hasAuthorship W4285394212A5014658993 @default.
- W4285394212 hasAuthorship W4285394212A5015617457 @default.
- W4285394212 hasAuthorship W4285394212A5029026130 @default.
- W4285394212 hasAuthorship W4285394212A5036496290 @default.
- W4285394212 hasAuthorship W4285394212A5037709572 @default.
- W4285394212 hasAuthorship W4285394212A5041515779 @default.
- W4285394212 hasAuthorship W4285394212A5057524030 @default.
- W4285394212 hasAuthorship W4285394212A5070093833 @default.
- W4285394212 hasAuthorship W4285394212A5073821889 @default.
- W4285394212 hasBestOaLocation W42853942121 @default.
- W4285394212 hasConcept C104317684 @default.
- W4285394212 hasConcept C107459253 @default.
- W4285394212 hasConcept C121608353 @default.
- W4285394212 hasConcept C126322002 @default.
- W4285394212 hasConcept C145103041 @default.
- W4285394212 hasConcept C1491633281 @default.
- W4285394212 hasConcept C207701140 @default.
- W4285394212 hasConcept C2776235491 @default.
- W4285394212 hasConcept C2776438761 @default.
- W4285394212 hasConcept C2778287671 @default.
- W4285394212 hasConcept C2779723316 @default.
- W4285394212 hasConcept C2780192828 @default.
- W4285394212 hasConcept C2780932548 @default.
- W4285394212 hasConcept C28328180 @default.
- W4285394212 hasConcept C502942594 @default.
- W4285394212 hasConcept C54355233 @default.
- W4285394212 hasConcept C55427017 @default.
- W4285394212 hasConcept C55493867 @default.
- W4285394212 hasConcept C555283112 @default.
- W4285394212 hasConcept C71924100 @default.
- W4285394212 hasConcept C86803240 @default.
- W4285394212 hasConcept C95444343 @default.
- W4285394212 hasConceptScore W4285394212C104317684 @default.
- W4285394212 hasConceptScore W4285394212C107459253 @default.
- W4285394212 hasConceptScore W4285394212C121608353 @default.
- W4285394212 hasConceptScore W4285394212C126322002 @default.
- W4285394212 hasConceptScore W4285394212C145103041 @default.
- W4285394212 hasConceptScore W4285394212C1491633281 @default.