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- W4285394295 abstract "Abstract High-throughput chromosome conformation capture (Hi-C) technique profiles the genomic structure in a genome-wide fashion. The reproducibility and consistency of Hi-C data are essential in characterizing dynamics of genomic structures. We developed a diffusion-based method, C T G (Hi-C To Geometry), to deal with the technical bias induced by insufficient sampling in sequencing and obtain reliable gemeotric information of the chromatin. C T G properly quantifies dubiously weak or even undetected interactions and produces a consistent and reproducible framework for the 3D genomic structure. C T G allows for a reliable genome-wide insight on the alteration of genomic structures under different cellular conditions and reveals correlations between genomic-proximal genes at both transcriptional and translational levels. Cell-specific correspondence between gene-gene and corresponding protein-protein physical interactions, as well as that with the transcription correlation reveals the coordinated inter-molecular structural and regulatory information passage in the central dogma." @default.
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- W4285394295 date "2022-07-13" @default.
- W4285394295 modified "2023-10-16" @default.
- W4285394295 title "Computational Enhanced Hi-C data reveals the function of structural geometry in genomic regulation" @default.
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- W4285394295 doi "https://doi.org/10.1101/2022.07.12.499232" @default.
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