Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285398857> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4285398857 endingPage "1862" @default.
- W4285398857 startingPage "1862" @default.
- W4285398857 abstract "The micro interface between two electrolyte solutions (micro-ITIES) has been exploited as a miniaturized electrochemical platform for detection of Pseudomonas aeruginosa . Electrochemical detection methods for point-of-care-devices in healthcare environments are ideal owing to their small equipment footprint and relative ease of use, while simultaneously, disposable electrode materials are easily fabricated. Meanwhile, P. aeruginosa is a pathogenic bacteria that poses a serious health risk to patients with compromised immune systems. Herein, a proof-of-concept electrochemical method is demonstrated that employs a micro-ITIES between water and oil (w/o) held at the tip of a glass capillary which targets two quorum sensing (QS) molecules produced throughout the bacteria’s life-cycle: 4‐hydroxy‐2‐heptylquinoline (HHQ) and 2‐heptyl‐3,4‐dihydroxyquinoline (PQS, Pseudomonas quinolone signal). QS molecules are used to signal colony growth in a pseudo-multicellular fashion; however, HHQ and PQS are also known virulence factors and are unique to this form of pathogenic bacteria. HHQ and PQS show excellent solubility in chlorinated organic solvent with limited partitioning to the aqueous phase. Moreover, as observed electrochemically, they facilitate proton transfer across the w/o interface which can be monitored/quantified and is exploited here as a means for early bacterial detection. This work demonstrates that the micro-ITIES can serve as a viable platform for P. aeruginosa identification and quantification. Density functional theory calculations were also performed to determine the proton affinities and gas-phase basicities of HHQ/PQS, as well as elucidate the likely site of stepwise protonation within each molecule. Figure 1" @default.
- W4285398857 created "2022-07-14" @default.
- W4285398857 creator A5003567702 @default.
- W4285398857 creator A5022602287 @default.
- W4285398857 date "2022-07-07" @default.
- W4285398857 modified "2023-09-25" @default.
- W4285398857 title "(Invited) Electrochemical Detection of Pseudomonas Aeruginosa Quorum Sensing Molecules at Micro Liquid|Liquid Interface Via Facilitated Proton Transfer Mechanism" @default.
- W4285398857 doi "https://doi.org/10.1149/ma2022-01431862mtgabs" @default.
- W4285398857 hasPublicationYear "2022" @default.
- W4285398857 type Work @default.
- W4285398857 citedByCount "0" @default.
- W4285398857 crossrefType "journal-article" @default.
- W4285398857 hasAuthorship W4285398857A5003567702 @default.
- W4285398857 hasAuthorship W4285398857A5022602287 @default.
- W4285398857 hasConcept C104317684 @default.
- W4285398857 hasConcept C118687296 @default.
- W4285398857 hasConcept C147789679 @default.
- W4285398857 hasConcept C171250308 @default.
- W4285398857 hasConcept C17525397 @default.
- W4285398857 hasConcept C178790620 @default.
- W4285398857 hasConcept C185592680 @default.
- W4285398857 hasConcept C192562407 @default.
- W4285398857 hasConcept C21951064 @default.
- W4285398857 hasConcept C2777637488 @default.
- W4285398857 hasConcept C2908737351 @default.
- W4285398857 hasConcept C32909587 @default.
- W4285398857 hasConcept C523546767 @default.
- W4285398857 hasConcept C52859227 @default.
- W4285398857 hasConcept C54355233 @default.
- W4285398857 hasConcept C55493867 @default.
- W4285398857 hasConcept C60987743 @default.
- W4285398857 hasConcept C86803240 @default.
- W4285398857 hasConceptScore W4285398857C104317684 @default.
- W4285398857 hasConceptScore W4285398857C118687296 @default.
- W4285398857 hasConceptScore W4285398857C147789679 @default.
- W4285398857 hasConceptScore W4285398857C171250308 @default.
- W4285398857 hasConceptScore W4285398857C17525397 @default.
- W4285398857 hasConceptScore W4285398857C178790620 @default.
- W4285398857 hasConceptScore W4285398857C185592680 @default.
- W4285398857 hasConceptScore W4285398857C192562407 @default.
- W4285398857 hasConceptScore W4285398857C21951064 @default.
- W4285398857 hasConceptScore W4285398857C2777637488 @default.
- W4285398857 hasConceptScore W4285398857C2908737351 @default.
- W4285398857 hasConceptScore W4285398857C32909587 @default.
- W4285398857 hasConceptScore W4285398857C523546767 @default.
- W4285398857 hasConceptScore W4285398857C52859227 @default.
- W4285398857 hasConceptScore W4285398857C54355233 @default.
- W4285398857 hasConceptScore W4285398857C55493867 @default.
- W4285398857 hasConceptScore W4285398857C60987743 @default.
- W4285398857 hasConceptScore W4285398857C86803240 @default.
- W4285398857 hasIssue "43" @default.
- W4285398857 hasLocation W42853988571 @default.
- W4285398857 hasOpenAccess W4285398857 @default.
- W4285398857 hasPrimaryLocation W42853988571 @default.
- W4285398857 hasRelatedWork W1977240360 @default.
- W4285398857 hasRelatedWork W2098305976 @default.
- W4285398857 hasRelatedWork W2204303416 @default.
- W4285398857 hasRelatedWork W2753146975 @default.
- W4285398857 hasRelatedWork W2782728189 @default.
- W4285398857 hasRelatedWork W2897597519 @default.
- W4285398857 hasRelatedWork W2937301320 @default.
- W4285398857 hasRelatedWork W2956124485 @default.
- W4285398857 hasRelatedWork W4225248469 @default.
- W4285398857 hasRelatedWork W4236990555 @default.
- W4285398857 hasVolume "MA2022-01" @default.
- W4285398857 isParatext "false" @default.
- W4285398857 isRetracted "false" @default.
- W4285398857 workType "article" @default.