Matches in SemOpenAlex for { <https://semopenalex.org/work/W4285404192> ?p ?o ?g. }
- W4285404192 endingPage "169686" @default.
- W4285404192 startingPage "169686" @default.
- W4285404192 abstract "Bimodal magnetic-fluorescent materials for diagnostic imaging needs surface-engineered nanoparticles with great biosafety, pronounced colloidal stability, high magnetic moments, and strong photoluminescence (PL) emission. This work presents polymer-coated nanoparticles (PCNPs) based on manganese ferrites covered with a thin shell of nitrogen-doped carbon dots for magnetic-resonance and fluorescent dual mode imaging of cancerous tumors in vivo. An in situ thermolysis of metal oxalates and phenylenediamine in diphenyl ether allows for the facile synthesis of hybrid magneto-fluorescent nanoparticles. They possess an average size of 55 ± 5 nm with strong and excitation-independent PL emission at about 600 nm with a saturation magnetization of ∼ 19 emu/g. In vivo dispersion and biosafety of the hybrid nanoparticles are improved by a polymer-coating strategy with the aid of Tween polysorbate. In vitro studies for SK-OV-3 cells reveal that PCNPs are not toxic up to a high concentration of 125 µg/mL. H&E-stained sections of vital organs of animals treated with dosages of 5 mg/kg fail to present any histopathological changes after 24 h post-injection. The fluorescence intensity in the tumor tissue region appears to increases over time and the tumor becomes clearly visible after 60 min. Magnetic resonance imaging (MRI) of phantoms and animal cases also indicates the high efficiency of PCNPs as an T2 contrast agent in clinical diagnosis. Therefore, the developed PCNPs offer great potential for dual mode imaging of malignant tumors." @default.
- W4285404192 created "2022-07-14" @default.
- W4285404192 creator A5002888212 @default.
- W4285404192 creator A5027550212 @default.
- W4285404192 creator A5040122671 @default.
- W4285404192 creator A5072097825 @default.
- W4285404192 creator A5078371519 @default.
- W4285404192 creator A5087254473 @default.
- W4285404192 creator A5089751406 @default.
- W4285404192 date "2022-11-01" @default.
- W4285404192 modified "2023-09-26" @default.
- W4285404192 title "Magneto-fluorescent contrast agents based on carbon Dots@Ferrite nanoparticles for tumor imaging" @default.
- W4285404192 cites W1591758121 @default.
- W4285404192 cites W1900489562 @default.
- W4285404192 cites W1965686857 @default.
- W4285404192 cites W1973831032 @default.
- W4285404192 cites W1977018826 @default.
- W4285404192 cites W1981381671 @default.
- W4285404192 cites W1985858988 @default.
- W4285404192 cites W1988520881 @default.
- W4285404192 cites W1991046617 @default.
- W4285404192 cites W1994463506 @default.
- W4285404192 cites W2000068330 @default.
- W4285404192 cites W2004037219 @default.
- W4285404192 cites W2014996256 @default.
- W4285404192 cites W2020335436 @default.
- W4285404192 cites W2021126570 @default.
- W4285404192 cites W2028643543 @default.
- W4285404192 cites W2029697229 @default.
- W4285404192 cites W2030395185 @default.
- W4285404192 cites W2031743190 @default.
- W4285404192 cites W2033503179 @default.
- W4285404192 cites W2034666969 @default.
- W4285404192 cites W2034736289 @default.
- W4285404192 cites W2037007757 @default.
- W4285404192 cites W2039985275 @default.
- W4285404192 cites W2041908678 @default.
- W4285404192 cites W2045807038 @default.
- W4285404192 cites W2048296917 @default.
- W4285404192 cites W2049157665 @default.
- W4285404192 cites W2051183893 @default.
- W4285404192 cites W2051445972 @default.
- W4285404192 cites W2052060937 @default.
- W4285404192 cites W2056064623 @default.
- W4285404192 cites W2061048353 @default.
- W4285404192 cites W2063563908 @default.
- W4285404192 cites W2068115580 @default.
- W4285404192 cites W2070550561 @default.
- W4285404192 cites W2077309466 @default.
- W4285404192 cites W2083476729 @default.
- W4285404192 cites W2100753997 @default.
- W4285404192 cites W2108524724 @default.
- W4285404192 cites W2111596670 @default.
- W4285404192 cites W2114918609 @default.
- W4285404192 cites W2119507443 @default.
- W4285404192 cites W2126346850 @default.
- W4285404192 cites W2134158792 @default.
- W4285404192 cites W2145688027 @default.
- W4285404192 cites W2148971764 @default.
- W4285404192 cites W2149819749 @default.
- W4285404192 cites W2162247723 @default.
- W4285404192 cites W2171804757 @default.
- W4285404192 cites W2172155995 @default.
- W4285404192 cites W2272904435 @default.
- W4285404192 cites W2286642719 @default.
- W4285404192 cites W2333726273 @default.
- W4285404192 cites W2336700193 @default.
- W4285404192 cites W2463130112 @default.
- W4285404192 cites W2573407289 @default.
- W4285404192 cites W2622851615 @default.
- W4285404192 cites W2752246194 @default.
- W4285404192 cites W2758437267 @default.
- W4285404192 cites W2777224448 @default.
- W4285404192 cites W2790855227 @default.
- W4285404192 cites W2805027485 @default.
- W4285404192 cites W2811001673 @default.
- W4285404192 cites W2895944291 @default.
- W4285404192 cites W2900199803 @default.
- W4285404192 cites W2901416565 @default.
- W4285404192 cites W2910231763 @default.
- W4285404192 cites W2911137915 @default.
- W4285404192 cites W2920950415 @default.
- W4285404192 cites W2922651833 @default.
- W4285404192 cites W2948575913 @default.
- W4285404192 cites W2951087046 @default.
- W4285404192 cites W2963347365 @default.
- W4285404192 cites W3123405800 @default.
- W4285404192 cites W3195528859 @default.
- W4285404192 cites W4205126740 @default.
- W4285404192 cites W4211262200 @default.
- W4285404192 cites W4241078711 @default.
- W4285404192 doi "https://doi.org/10.1016/j.jmmm.2022.169686" @default.
- W4285404192 hasPublicationYear "2022" @default.
- W4285404192 type Work @default.
- W4285404192 citedByCount "4" @default.
- W4285404192 countsByYear W42854041922023 @default.
- W4285404192 crossrefType "journal-article" @default.
- W4285404192 hasAuthorship W4285404192A5002888212 @default.